Results 81 to 90 of about 194,060 (257)

A host defense role for Fibrinogen by direct binding of Clostridium botulinum C2 toxin

Cellular and Molecular Life Sciences
In addition to fibrinogens canonical function in hemostasis, alternate roles in innate immunity have emerged. However, interactions with bacterial protein toxins, the main virulence factors of many medically relevant bacteria and causative agents of life-
Sophia Kistermann, Sebastian Heber, Stephan Fischer, Jannik Sichau, Christoph Q. Schmidt, Marco Mannes, Markus Huber-Lang, Holger Barth   +7 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Rare‐Earth–Functionalized Carbon Dot Hydrogels as Mechanically Robust Antibacterial Wound Dressings

Advanced Healthcare Materials, EarlyView.
The schematic depicts a dynamically cross‐linked PVA hydrogel network in which reversible borate ester bonds and hydrogen‐bonding interactions integrate lanthanum‐doped carbon dots (La‐CDs) and dipotassium glycyrrhizinate (DPG) to form a mechanically robust, multifunctional matrix.
Shih‐Han Tsai, Ramadhass Keerthika Devi, Muthusankar Ganesan, Guo‐Ping Chang Chien, Chun Che Lin   +4 more
wiley   +1 more source

Editorial: Venoms, Animal and Microbial Toxins

Frontiers in Pharmacology, 2021
Zhijian Cao, Jing-Lin Wang, Patrick Michael McNutt, Yuri N. Utkin, Delavar Shahbazzadeh, Heike Wulff, Hervé Kovacic, Jean-Marc Sabatier   +7 more
doaj   +1 more source

Repurposing caspofungin as a small-molecule inhibitor of Clostridium perfringens α-toxin for treatment of gas gangrene

Communications Medicine
Background Among pharmaceuticals currently in clinical use, few drugs directly target bacterial toxins. Clostridium perfringens α-toxin, a phospholipase C (PLC), is a major virulence factor responsible for gas gangrene caused by C.
Masaya Takehara, Yuta Homma, Tomoaki Ishihara, Yoshihiko Sakaguchi, Yusuke Kasai, Kanako Matsumoto, Katsuyuki Nakashima, Toshiyuki Yamaji, Yoshiyuki Tanaka, Hiroshi Imagawa, Masahiro Nagahama   +10 more
doaj   +1 more source

Pharmacological inhibition of host cell neddylation reduces intoxication of cells by diphtheria toxin and clostridial enterotoxins TcdB and C2

Microbiology Spectrum
NEDD8 is a ubiquitin-like molecule that is conjugated to lysine residues of protein substrates in a process known as neddylation, which affects their stability, degradation, and interactions.
Irina König, Katharina Oßwald, Lisa Schneider, Holger Barth, Panagiotis Papatheodorou   +4 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis

Advanced Materials, EarlyView.
Eutectozymes are sustainable hybrid materials that embed a GOx–HRP cascade within hydrophobic eutectogels featuring a dual supramolecular–covalent network. This architecture preserves native enzyme structure and stability, enables efficient heterogeneous biocatalysis in aqueous media, and positions eutectogels as robust platforms for next‐generation ...
Manuel Eduardo Martinez Cartagena, Lucia Suarez, Aitor Ontoria, Francisca J. Benitez, Elixabete Rezabal, María Soledad Orellano, Marcelo Calderón, Cristián Huck‐Iriart, Agustin S. Picco, Matias L. Picchio, Ana Beloqui   +10 more
wiley   +1 more source