Results 71 to 80 of about 955,627 (248)

Toxinome—the bacterial protein toxin database

mBio
Protein toxins are key molecular weapons in biology that are used to attack neighboring cells. Bacteria use protein toxins to kill or inhibit the growth of prokaryotic and eukaryotic cells using various modes of action that target essential cellular ...
Aleks Danov, Ofir Segev, Avi Bograd, Yedidya Ben Eliyahu, Noam Dotan, Tommy Kaplan, Asaf Levy   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Replication of plasmids derived from Shiga toxinconverting bacteriophages in starved Escherichia coli [PDF]

, 2011
The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that replication of the
Nejman, Bożena, Nadratowska-Wesołowska, Beata, Węgrzyn, Alicja, Węgrzyn, Grzegorz, Szalewska-Pałasz, Agnieszka   +4 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

c-di-AMP accumulation impairs toxin expression of Bacillus anthracis by down-regulating potassium importers

Microbiology Spectrum
The Gram-positive bacterium Bacillus anthracis is the causative agent of anthrax and a bioterrorism threat worldwide. As a crucial second messenger in many bacterial species, cyclic di-AMP (c-di-AMP) modulates various key processes for bacterial ...
Jia Hu, Junmin Yao, Chengfeng Lei, Xiulian Sun   +3 more
doaj   +1 more source

Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections

Frontiers in Cellular and Infection Microbiology, 2017
Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion.
Rachid A. El-Aouar Filho, Rachid A. El-Aouar Filho, Aurélie Nicolas, Thiago L. De Paula Castro, Martine Deplanche, Vasco A. De Carvalho Azevedo, Pierre L. Goossens, Frédéric Taieb, Gerard Lina, Gerard Lina, Gerard Lina, Yves Le Loir, Nadia Berkova   +12 more
doaj   +1 more source

RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium.

PLoS Genetics, 2020
RHS elements are components of conserved toxin-delivery systems, wide-spread within the bacterial kingdom and some of the most positively selected genes known. However, very little is known about how Rhs toxins affect bacterial biology.
Magnus Stårsta, Disa L Hammarlöf, Marcus Wäneskog, Susan Schlegel, Feifei Xu, Arvid Heden Gynnå, Malin Borg, Sten Herschend, Sanna Koskiniemi   +8 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralising antibodies induced during human infection but not chicken colonisation [PDF]

, 2005
The cytolethal distending toxin (CDT) of Campylobacter jejuni was detectable, using an in vitro assay, in most but not all of 24 strains tested. The reason for the absence of toxin activity in these naturally occurring CDT-negative C.
Ridley, A, Wassenaar, TM, Ahmed, IH, Cawthraw, SA, AbuOun, M, Manning, G, Newell, DG   +6 more
core  

The entomopathogenic bacterial endosymbionts Xenorhabdus and Photorhabdus: convergent lifestyles from divergent genomes [PDF]

, 2011
Members of the genus Xenorhabdus are entomopathogenic bacteria that associate with nematodes. The nematode-bacteria pair infects and kills insects, with both partners contributing to insect pathogenesis and the bacteria providing nutrition to the ...
Givaudan, Alain, Karina C. Krasomil-Osterfeld, Goldman, Barry S., Youngjin Park, Brian C. Tjaden, Latreille Phil, Kimberly N Cowles, Carolyn M Lipke, Slominski Kathryn, Jennifer J. Knack, Menard, Megan L., Jewell, Kelsea A., Slominski, Kathryn, Karina C Krasomil-Osterfeld, Bosong Xiang, Kelsea A Jewell, Park Youngjin, Carolyn M. Lipke, Norton, Stacie, Archna Bhasin, Darby Renneckar Sugar, Sugar, Darby Renneckar, Nydia Morales-Soto, Miller Nancy M., Latreille, Phil, Andersen Aaron W., Barry S. Goldman, Lipke, Carolyn M., Barbara A. Qurollo, Kukor, Ryan, Martens Eric C., Brachmann, Alexander O., Welch Roy D., Qurollo, Barbara A., Jewell Kelsea A., Barbazuk, Brad, Jennifer J Knack, Slater, Steven C., Holly Snyder, van der Hoeven, Ransome, Anne Lanois, John M. Chaston, John M Chaston, Xiang, Bosong, Alain Givaudan, Lu, Xiaojun, Chaston, John M., Knack, Jennifer J., Ogier, Jean-Claude, Drace Kevin, Renyi Liu, Dongjin Park, Suen, Garret, Andersen, Aaron W., Park, Dongjin, Kimberly N. Cowles, Nancy K. Leimgruber, Zoé Rouy, Krasomil-Osterfeld, Karina C., Roy D Welch, Darby Creg, Claudine Médigue, Xiang Bosong, Tran, Erin E. Herbert, Erin E Herbert Tran, Park Dongjin, Lu Xiaojun, Park, Youngjin, Jean-Claude Ogier, Roy D. Welch, Morales-Soto, Nydia, Steven C. Slater, Kevin Drace, Médigue, Claudine, de Léon, Limaris, Helge B. Bode, Xiaojun Lu, Leimgruber Nancy K., Edna Bode, Brad Barbazuk, Nancy M. Miller, Megan L. Menard, Welch, Roy D., Synder, Holly, Eric C Martens, Liu, Renyi, Barry S Goldman, Brad Goodner, Orchard Samantha S., Steven C Slater, Cowles Kimberly N., Rouy Zoé, Zijin Du, Forst Steven, Ransome van der Hoeven, Erin E. Herbert Tran, Bode, Edna, Suen Garret, Chaston John M., Liu Renyi, Gregory R. Richards, Knack Jennifer J., Wheeler, Cathy, Pradeep R Marri, Snyder, Holly, Samantha S Orchard, Drace, Kevin, Marri Pradeep R., Brian C Tjaden, Brachmann Alexander O., Marri, Pradeep R., Limaris de Léon, Goldman Barry S., Gaudriault Sophie, Garret Suen, Slominski Brad, Gaudriault, Sophie, Sugar Darby Renneckar, Charles E. Cowles, Forst, Steven, Sophie Gaudriault, Goodrich-Blair, Heidi, Kathryn Slominski, Lipke Carolyn M., Heidi Goodrich-Blair, Gaudriault, Sophie, S., Cathy Wheeler, Charles E Cowles, Martens, Eric C., Sarah L Tucker, Givaudan Alain, Goodrich-Blair Heidi, Richards, Gregory R., Gregory R Richards, Aaron W Andersen, Miller, Nancy M., Phil Latreille, Ryan Kukor, Qurollo Barbara A., Barbazuk Brad, Tucker Sarah L., Cowles Charles E., Cowles, Kimberly N., Barbara A Qurollo, Lanois Anne, Snyder Holly, Darby, Creg, Léon, Limaris de, Bhasin Archna, Pradeep R. Marri, Leimgruber, Nancy K., Bhasin, Archna, Nancy M Miller, Brad Slominski, Bode, Helge Björn, Cowles, Charles E., Bode Edna, Slominski, Brad, Tjaden, Brian C., Kukor Ryan, Stacie Norton, Alexander O. Brachmann, Rouy, Zoé, Slater Steven C., Eric C. Martens, Lanois, Anne, Steven Forst, Hoeven, Ransome van der, Bode Helge B., Creg Darby, Aaron W. Andersen, Médigue Claudine, van der Hoeven Ransome, Alexander O Brachmann, Nancy K Leimgruber, Krasomil-Osterfeld Karina C., Menard Megan L., Kelsea A. Jewell, Sarah L. Tucker, Renneckar Sugar, Darby, Wheeler Cathy, Goodner, Brad, Morales-Soto Nydia, Goodner Brad, Bode, Helge B., Megan L Menard, Richards Gregory R., Norton Stacie, Helge B Bode, Du, Zijin, Orchard, Samantha S., de Léon Limaris, Tucker, Sarah L., Brachmann, Alexander Oliver, Du Zijin, Herbert Tran Erin E., Ogier Jean-Claude, Samantha S. Orchard, Tjaden Brian C.   +198 more
core   +2 more sources