Rapid bacteriolysis of Staphylococcus aureus by lysin exebacase [PDF]
Microbiology Spectrum, 2023 Lysins (peptidoglycan hydrolases) are promising new protein-based antimicrobial candidates under development to address rising antibiotic resistance encountered among pathogenic bacteria.
Xavier Vila-Farres +6 more
doaj +4 more sources
Intracellular bacteriolysis contributes to pathogenicity of Staphylococcus aureus by exacerbating AIM2-mediated inflammation and necroptosis [PDF]
Virulence, 2022 Staphylococcus aureus can survive within phagocytes. Indeed, we confirm in this study that approximately 10% of population persists in macrophages during S.
Shiyuan Feng +8 more
doaj +2 more sources
Image-Based Dynamic Phenotyping Reveals Genetic Determinants of Filamentation-Mediated β-Lactam Tolerance [PDF]
Frontiers in Microbiology, 2020 Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Taiyeb Zahir +15 more
doaj +4 more sources
Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis [PDF]
eLife, 2022 Cellular respiration is essential for multiple bacterial pathogens and a validated antibiotic target. In addition to driving oxidative phosphorylation, bacterial respiration has a variety of ancillary functions that obscure its contribution to ...
Rafael Rivera-Lugo +12 more
doaj +2 more sources
Synergistic Activity of Fosfomycin, Ciprofloxacin, and Gentamicin Against Escherichia coli and Pseudomonas aeruginosa Biofilms [PDF]
Frontiers in Microbiology, 2019 Gram-negative (GN) rods cause about 10% periprosthetic joint infection (PJI) and represent an increasing challenge due to emergence of antimicrobial resistance.
Lei Wang +8 more
doaj +3 more sources
A Novel Antimicrobial Metabolite Produced by Paenibacillus apiarius Isolated from Brackish Water of Lake Balkhash in Kazakhstan [PDF]
Microorganisms, 2022 Four aerobic bacteria with bacteriolytic capabilities were isolated from the brackish water site Strait Uzynaral of Lake Balkhash in Kazakhstan. The morphology and physiology of the bacterial isolates have subsequently been analyzed.
Alexander Meene +8 more
doaj +2 more sources
Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. [PDF]
PLoS ONE, 2013 Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Jasmin Schwab +7 more
doaj +12 more sources
Enhancement of bacteriolysis of Shuffled phage PhiX174 gene E [PDF]
Virology Journal, 2011 Bacterial ghosts that are generated using the regulated PhiX174 lysis gene E offer a new avenue for the study of inactivated vaccines. Here, we constructed a library of mutant gene E using a gene-shuffling technique.
Wang Chun-lai +9 more
doaj +3 more sources
Synergistic Antibacterial Effect of Ethyl Acetate Fraction of Vernonia amygdalina Delile Leaves with Tetracycline against Clinical Isolate Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa [PDF]
Advances in Pharmacological and Pharmaceutical Sciences, 2023 Multidrug-resistant bacteria have raised global concern about the inability to fight deadly infectious diseases. Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa are the most common resistant bacteria that are causing ...
Denny Satria +5 more
doaj +2 more sources
Structural insights into Cir-mediated killing by the antimicrobial protein Microcin V [PDF]
Communications BiologyDrug-resistant bacteria are a global concern. Novel treatments are needed, but are difficult to develop for Gram-negative species due to the need to traverse the outer membrane to reach targets beneath.
Stavros A. Maurakis +5 more
doaj +2 more sources