Results 1 to 10 of about 261,858 (336)

Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair

mBio, 2021
Bacteriophages (phages) are viruses that infect bacteria and use them as replication factories to assemble progeny phages. Bacteria have evolved powerful defense mechanisms to destroy the invading phages by severing their genomes soon after entry into ...
Xiaorong Wu, Jingen Zhu, Pan Tao, Venigalla B. Rao   +3 more
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Design of bacteriophage T4-based artificial viral vectors for human genome remodeling

Nature Communications, 2023
Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter human cells and carry out molecular repairs will have broad applications.
Jingen Zhu, Himanshu Batra, Neeti Ananthaswamy, Marthandan Mahalingam, Pan Tao, Xiaorong Wu, Wenzheng Guo, Andrei Fokine, Venigalla B. Rao   +8 more
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Animal Models in the Evaluation of the Effectiveness of Phage Therapy for Infections Caused by Gram-Negative Bacteria from the ESKAPE Group and the Reliability of Its Use in Humans

Microorganisms, 2021
The authors emphasize how extremely important it is to highlight the role played by animal models in an attempt to determine possible phage interactions with the organism into which it was introduced as well as to determine the safety and effectiveness ...
Martyna Cieślik, Natalia Bagińska, Andrzej Górski, Ewa Jończyk-Matysiak   +3 more
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Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response

Cells, 2021
Studies described so far suggest that human β-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. Its pivotal
Martyna Cieślik, Natalia Bagińska, Andrzej Górski, Ewa Jończyk-Matysiak   +3 more
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The Role of Antibiotic Resistant A. baumannii in the Pathogenesis of Urinary Tract Infection and the Potential of Its Treatment with the Use of Bacteriophage Therapy

Antibiotics, 2021
Acinetobacter baumannii are bacteria that belong to the critical priority group due to their carbapenems and third generation cephalosporins resistance, which are last-chance antibiotics.
Natalia Bagińska, Martyna Cieślik, Andrzej Górski, Ewa Jończyk-Matysiak   +3 more
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Biological Properties of 12 Newly Isolated Acinetobacter baumannii-Specific Bacteriophages

Viruses, 2023
Infections with the opportunistic Gram-negative bacterium Acinetobacter baumannii pose a serious threat today, which is aggravated by the growing problem of multi-drug resistance among bacteria, caused by the overuse of antibiotics.
Natalia Bagińska, Marek Adam Harhala, Martyna Cieślik, Filip Orwat, Beata Weber-Dąbrowska, Krystyna Dąbrowska, Andrzej Górski, Ewa Jończyk-Matysiak   +7 more
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Investigating bacteriophages targeting the opportunistic pathogen Acinetobacter baumannii [PDF]

, 2020
The multi-drug resistance of the opportunistic pathogen Acinetobacter baumannii is of growing concern, with many clinical isolates proving to be resistant to last resort as well as front line antibiotic treatments.
Christie, Gabrielle S., Dowson, Christopher G., Leungtongkam, Udomluk, Millard, Andrew D., Moat, John, Sagona, Antonia P., Sitthisak, Sutthirat, Smith, Sophie, Styles, Kathryn, Thummeepak, Rapee, Wellington, Elizabeth M. H.   +10 more
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Bacteriophages and antibiotic interactions in clinical practice: what we have learned so far

Journal of Biomedical Science, 2022
Bacteriophages (phages) may be used as an alternative to antibiotic therapy for combating infections caused by multidrug-resistant bacteria. In the last decades, there have been studies concerning the use of phages and antibiotics separately or in ...
Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Zuzanna Drulis-Kawa, Kathryn Cater, Petar Knežević, Cyprian Winogradow, Karolina Amaro, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Justyna Rękas, Andrzej Górski   +10 more
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How Interest in Phages Has Bloomed into a Leading Medical Research Activity in Poland

Viruses, 2022
Poland has a leading position in phage therapy, as reflected by the number of patients treated and relevant publications in quality journals. The Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences was established by Ludwik
Maciej Żaczek, Andrzej Górski, Andrzej Grzybowski, Edyta Pasternak, Beata Weber-Dąbrowska, Ryszard Międzybrodzki   +5 more
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Immune Response to Therapeutic Staphylococcal Bacteriophages in Mammals: Kinetics of Induction, Immunogenic Structural Proteins, Natural and Induced Antibodies

Frontiers in Immunology, 2021
Bacteriophages are able to affect the human immune system. Phage-specific antibodies are considered as major factors shaping phage pharmacokinetics and bioavailability.
Zuzanna Kaźmierczak, Zuzanna Kaźmierczak, Joanna Majewska, Paulina Miernikiewicz, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Sylwia Nowak, Marek Harhala, Dorota Lecion, Weronika Kęska, Barbara Owczarek, Jarosław Ciekot, Marek Drab, Paweł Kędzierski, Marta Mazurkiewicz-Kania, Andrzej Górski, Krystyna Dąbrowska   +16 more
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