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Bacteriophages and their genomes [PDF]
Current Opinion in Virology, 2011 Bacteriophages occupy a unique position in biology, representing an absolute majority of all organisms in the biosphere. Because their genomes are relatively small, elucidating the genetic diversity of the phage population, deciphering their origins, and identifying the evolutionary mechanisms that shape the population would seem readily feasible.
Graham F, Hatfull, Roger W, Hendrix
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Annual Review of Microbiology, 2001 ▪ Abstract In 1917, bacteriophages were recognized as epizootic infections of bacteria and were almost immediately deployed for antibacterial therapy and prophylaxis. The early trials of bacteriophage therapy for infectious diseases were confounded, however, because the biological nature of bacteriophage was poorly understood.
A, Sulakvelidze +2 more
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Viruses, 2018 A potential concern with bacteriophage (phage) therapeutics is a host-versus-phage response in which the immune system may neutralize or destroy phage particles and thus impair therapeutic efficacy, or a strong inflammatory response to repeated phage ...
Helen R. Freyberger +4 more
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The superimmunity gene sim of bacteriophage P1 causes superinfection exclusion [PDF]
, 1989 Kliem M, Dreiseikelmann B. The superimmunity gene sim of bacteriophage P1 causes superinfection exclusion. Virology. 1989;171(2):350-355.Previous work has shown that the sim gene of bacteriophage P1, if cloned into a multicopy vector, confers immunity ...
Dreiseikelmann, Brigitte, Kliem, Manfred
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Do Anti-Phage Antibodies Persist after Phage Therapy? A Preliminary Report
Antibiotics, 2022 Phages are immunogenic and may evoke an immune response following their administration. Consequently, patients undergoing phage therapy (PT) produce phage-neutralizing serum antibodies.
Marzanna Łusiak-Szelachowska +5 more
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Microorganisms, 2020 Despite their simplicity, viruses can display social-like interactions such as cooperation, communication, and cheating. Focusing on bacteriophages, here we review features including viral product sharing, cooperative evasion of antiviral defenses, prudent host exploitation, superinfection exclusion, and inter-phage peptide-mediated signaling. We argue
Pilar Domingo-Calap +2 more
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Cloning, sequencing, and overexpression of gene 16 of salmonella bacteriophage P22 [PDF]
, 1992 Umlauf B, Dreiseikelmann B. Cloning, sequencing, and overexpression of gene 16 of salmonella bacteriophage P22. Virology. 1992;188(2):495-501.It has been suggested that gene product 16 of bacteriophage P22 forms a pore for DNA transfer and/or that it ...
Dreiseikelmann, Brigitte +1 more
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The Presence of Bacteriophages in the Human Body: Good, Bad or Neutral?
Microorganisms, 2020 The presence of bacteriophages (phages) in the human body may impact bacterial microbiota and modulate immunity. The role of phages in human microbiome studies and diseases is poorly understood.
Marzanna Łusiak-Szelachowska +4 more
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Potential for Phages in the Treatment of Bacterial Sexually Transmitted Infections
Antibiotics, 2021 Bacterial sexually transmitted infections (BSTIs) are becoming increasingly significant with the approach of a post-antibiotic era. While treatment options dwindle, the transmission of many notable BSTIs, including Neisseria gonorrhoeae, Chlamydia ...
Kathryn Cater +7 more
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Viruses, 2021 Since the beginning of the 20th century, bacteriophages (phages), i.e., viruses that infect bacteria, have been used as antimicrobial agents for treating various infections. Phage preparations targeting a number of bacterial pathogens are still in use in
Nata Bakuradze +12 more
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