Results 111 to 120 of about 441,842 (342)

Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal

Viruses, 2018
Bacteriophage-derived endolysins have gained increasing attention as potent antimicrobial agents and numerous publications document the in vivo efficacy of these enzymes in various rodent models. However, little has been documented about their safety and
Marek Harhala, Daniel C. Nelson, Paulina Miernikiewicz, Ryan D. Heselpoth, Beata Brzezicka, Joanna Majewska, Sara B. Linden, Xiaoran Shang, Aleksander Szymczak, Dorota Lecion, Karolina Marek-Bukowiec, Marlena Kłak, Bartosz Wojciechowicz, Karolina Lahutta, Andrzej Konieczny, Krystyna Dąbrowska   +15 more
doaj   +1 more source

Unlocking the M13 (F1) virion : investigation into the role of pIII C domain of F specific filamentous bacteriophage in infection : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]

, 2005
Filamentous phage adsorb to the host cells by binding of the N2 domain of pIII to the tip of the F pilus. Binding of N1 domain of pIII to the secondary receptor (Tol A), triggers the opening of the virion by a poorly understood mechanism.
Bennett, Nicholas James
core  

Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles

Frontiers in Cellular and Infection Microbiology, 2018
Increasing reports of antimicrobial resistance and limited new antibiotic discoveries and development have fuelled innovation in other research fields and led to a revitalization of bacteriophage (phage) studies in the Western world. Phage therapy mainly
L. Furfaro, M. Payne, B. Chang
semanticscholar   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa. [PDF]

, 2014
Bacteria develop a broad range of phage resistance mechanisms, such as prevention of phage adsorption and CRISPR/Cas system, to survive phage predation.
He, Xuesong, Hu, Fuquan, Jin, Xiaolin, Le, Shuai, Li, Ming, Lu, Shuguang, Lux, Renate, Rao, Xiancai, Shi, Wenyuan, Tan, Yinling, Wang, Jing, Wu, Nicholas C, Yao, Xinyue, Zhao, Yan   +13 more
core   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

Phage Therapy in Poland – a Centennial Journey to the First Ethically Approved Treatment Facility in Europe

Frontiers in Microbiology, 2020
Although phage discovery is an unquestionable merit of the English bacteriologist Frederick W. Twort and the Canadian–French microbiologist Félix d’Hérelle, who both discovered phages over 100 years ago, the Polish history of phage studies also dates ...
Maciej Żaczek, Beata Weber-Dąbrowska, Beata Weber-Dąbrowska, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Ryszard Międzybrodzki, Marzanna Łusiak-Szelachowska, Andrzej Górski, Andrzej Górski   +8 more
doaj   +1 more source

Molecular Characterisation of Bacteriophage K Towards Applications for the Biocontrol of Pathogenic Staphylococci [PDF]

, 2006
End of project reportThe aim of this work was to characterise staphylococcal bacteriophage (a bacterial virus) and to assess their potential as therapeutic agents against pathogenic strains of Staphylococcus aureus, particularly mastitis-causing strains.
Coffey, Aidan, Fitzgerald, Gerald F, Flynn, James, Meaney, William J, O'Flaherty, Sarah, Ross, R Paul   +5 more
core  

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models

iScience
Summary: A major barrier for HIV-1 eradication is the latent virus reservoir containing stably integrated and silent proviruses in CD4+ T cells. Targeted reactivation and removal of this latent reservoir is a potential strategy for HIV-1 cure, but ...
Himanshu Batra, Jingen Zhu, Swati Jain, Neeti Ananthaswamy, Marthandan Mahalingam, Pan Tao, Camille Lange, Shawn Hill, Chaojie Zhong, Mary F. Kearney, Haitao Hu, Frank Maldarelli, Venigalla B. Rao   +12 more
doaj   +1 more source