Results 81 to 90 of about 434,771 (384)

Seeker: Alignment-free identification of bacteriophage genomes by deep learning

bioRxiv, 2020
Advances in metagenomics enable massive discovery of diverse, distinct microbes and viruses. Bacteriophages, the most abundant biological entity on Earth, evolve rapidly, and therefore, detection of unknown bacteriophages in sequence datasets is a ...
Noam Auslander, Ayal B. Gussow, Sean Benler, Y. Wolf, E. Koonin   +4 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Bacteriolytic Potential of Enterococcus Phage iF6 Isolated from “Sextaphag^®” Therapeutic Phage Cocktail and Properties of Its Endolysins, Gp82 and Gp84

Viruses, 2023
The number of infections caused by antibiotic-resistant strains of bacteria is growing by the year. The pathogenic bacterial species Enterococcus faecalis and Enterococcus faecium are among the high priority candidate targets for the development of new ...
Rustam M. Buzikov, Olesya A. Kazantseva, Emma G. Piligrimova, Natalya A. Ryabova, Andrey M. Shadrin   +4 more
doaj   +1 more source

Heterogeneous Klebsiella pneumoniae Co-infections Complicate Personalized Bacteriophage Therapy

Frontiers in Cellular and Infection Microbiology, 2021
Multidrug-resistant (MDR) organisms have increased worldwide, posing a major challenge for the clinical management of infection. Bacteriophage is expected as potential effective therapeutic agents for difficult-to-treat infections.
Jinhong Qin, Nannan Wu, Juan Bao, Xin Shi, Hongyu Ou, Shanke Ye, W. Zhao, Zhenquan Wei, Jinfeng Cai, Lisha Li, Mingquan Guo, Jingyan Weng, Hongzhou Lu, Demeng Tan, Jianzhong Zhang, Qin Huang, Zhaoqin Zhu, Yejing Shi, Chunlan Hu, Xiaokui Guo, T. Zhu   +20 more
semanticscholar   +1 more source

Bacteriophages and Biofilms [PDF]

Antibiotics, 2014
Biofilms are an extremely common adaptation, allowing bacteria to colonize hostile environments. They present unique problems for antibiotics and biocides, both due to the nature of the extracellular matrix and to the presence within the biofilm of metabolically inactive persister cells.
Helena M. R. T. Parracho, Gavin Hughes, Richard Sharp, David R Harper, James T. Walker, Sandra Morales, Susan M. Lehman, Maria Werthén   +7 more
openaire   +3 more sources

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Characterization of bacteriophage vB_KleM_KB2 possessing high control ability to pathogenic Klebsiella pneumoniae

Scientific Reports, 2023
Klebsiella pneumoniae is a widespread pathogen of several human diseases. The emergence of multidrug-resistant K. pneumoniae makes the treatment of these diseases a significant challenge.
Qin Peng, Zimeng Ma, Qing Han, Fangfang Xiang, Lushuang Wang, Yibin Zhang, Yuting Zhao, Jianing Li, Yaxin Xian, Yihui Yuan   +9 more
doaj   +1 more source

Bacteriophage Therapy: Developments and Directions

Antibiotics, 2020
In an era of proliferating multidrug resistant bacterial infections that are exhausting the capacity of existing chemical antibiotics and in which the development of new antibiotics is significantly rarer, Western medicine must seek additional ...
M. Nikolich, A. Filippov
semanticscholar   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa. [PDF]

, 2014
Bacteria develop a broad range of phage resistance mechanisms, such as prevention of phage adsorption and CRISPR/Cas system, to survive phage predation.
He, Xuesong, Hu, Fuquan, Jin, Xiaolin, Le, Shuai, Li, Ming, Lu, Shuguang, Lux, Renate, Rao, Xiancai, Shi, Wenyuan, Tan, Yinling, Wang, Jing, Wu, Nicholas C, Yao, Xinyue, Zhao, Yan   +13 more
core   +1 more source