Results 81 to 90 of about 261,858 (336)

Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo. [PDF]

, 2014
Staphylococcus aureus is a commensal and major pathogen of humans and animals. Comparative genomics of S. aureus populations suggests that colonization of different host species is associated with carriage of mobile genetic elements (MGE), particularly ...
Gould, KA, Lindsay, JA, Lloyd, DH, Loeffler, A, McCarthy, AJ, Witney, AA   +5 more
core   +1 more source

Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
New formulations of lipid nanoparticles (LNPs) that can deliver nucleic acids to Gram‐negative bacteria are proposed to combat bacterial infection. The delivery of nucleic acids by LNPs is aided by LNP‐helpers which weaken the bacterial outer membrane. LNPs encapsulating the Cas13a/gRNA expression vector achieve an antibacterial effect in both in vivo ...
Bookun Kim, Hwi Won Seo, Kyuri Lee, Dongeun Yong, Yoon Kyung Park, Yujin Lee, Solip Lee, Do‐Wan Kim, Dajeong Kim, Choong‐Min Ryu   +9 more
wiley   +1 more source

Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal

Viruses, 2018
Bacteriophage-derived endolysins have gained increasing attention as potent antimicrobial agents and numerous publications document the in vivo efficacy of these enzymes in various rodent models. However, little has been documented about their safety and
Marek Harhala, Daniel C. Nelson, Paulina Miernikiewicz, Ryan D. Heselpoth, Beata Brzezicka, Joanna Majewska, Sara B. Linden, Xiaoran Shang, Aleksander Szymczak, Dorota Lecion, Karolina Marek-Bukowiec, Marlena Kłak, Bartosz Wojciechowicz, Karolina Lahutta, Andrzej Konieczny, Krystyna Dąbrowska   +15 more
doaj   +1 more source

Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. [PDF]

, 2012
UnlabelledInvestigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial ...
Bowman, Charles, Cokus, Shawn, Fitz-Gibbon, Sorel, Hatfull, Graham F, Hayes, Clarmyra, Inkeles, Megan, Jacobs-Sera, Deborah, Kim, Jenny, Loncaric, Anya, Marinelli, Laura J, Miller, Jeff F, Modlin, Robert L, Pellegrini, Matteo, Russell, Daniel A   +13 more
core   +2 more sources

Integrin β4‐Enriched Small Extracellular Vesicle as Drug Delivery Vehicle for Targeting Pulmonary Metastasis of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
The expression of integrin β4 (ITGβ4) on small extracellular vesicle (sEV) correlates with lung‐tropism. Enrichment of ITGβ4 on sEVs enhances their lung‐targeting ability. The sEVs loaded with doxorubicin exhibit superior therapeutic efficacy in a lung metastasis mouse model.
Tung Him Ng, Aijun Liang, Maximus CF Yeung, Sze Keong Tey, Kam‐Leung Siu, Sin‐Yee Fung, Dong‐Yan Jin, Judy Wai Ping Yam   +7 more
wiley   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Bacteriophage-resistant and bacteriophage-sensitive bacteria in a chemostat [PDF]

Mathematical Biosciences and Engineering, 2012
In this paper a mathematical model of the population dynamics of a bacteriophage-sensitive and a bacteriophage-resistant bacteria in a chemostat where the resistant bacteria is an inferior competitor for nutrient is studied. The focus of the study is on persistence and extinction of bacterial strains and bacteriophage.
Zhun Han, Hal L. Smith
openaire   +3 more sources

Topology in Biological Piezoelectric Materials

Advanced Materials, EarlyView.
This review summarizes the topological structures in biological piezoelectric materials, covering morphology evolution, spatial arrangement, and biomimetic strategies. These topologies modulate structure‐property relationships across multiple scales, enabling performance enhancement and multifunctional integration.
Chen Chen, Yanhu Zhang, Yi Zheng, Yi Zhang, Hongyi Liu, Jiang Wu, Liang Yang, Zhengbao Yang   +7 more
wiley   +1 more source

High-Throughput Bacteriophage Testing with Potency Determination: Validation of an Automated Pipetting and Phage Drop-Off Method

Biomedicines
The development of bacteriophages (phages) as active pharmaceutical ingredients for the treatment of patients is on its way and regulatory agencies are calling for reliable methods to assess phage potency.
Nicolas Dufour, Raphaëlle Delattre, Laurent Debarbieux   +2 more
doaj   +1 more source

Effective elimination of Staphylococcal contamination from hospital surfaces by a bacteriophage-probiotic sanitation strategy: a monocentric study. [PDF]

, 2019
Persistent contamination of hospital surfaces and antimicrobial resistance (AMR) are recognized major causes of healthcare-associated infections (HAI). We recently showed that a probiotic-based sanitation (PCHS) can stably decrease surface pathogens and ...
BISI, Matteo, CASELLI, Elisabetta, D'ACCOLTI, Maria, LANZONI, Luca, MAZZACANE, Sante, SOFFRITTI, IRENE, VOLTA, Antonella   +6 more
core   +1 more source