Results 51 to 60 of about 20,664 (176)

Natural biased coin encoded in the genome determines cell strategy. [PDF]

PLoS ONE, 2014
Decision making at a cellular level determines different fates for isogenic cells. However, it is not yet clear how rational decisions are encoded in the genome, how they are transmitted to their offspring, and whether they evolve and become optimized ...
Faezeh Dorri, Hamid Mahini, Ali Sharifi-Zarchi, Mehdi Totonchi, Ruzbeh Tusserkani, Hamid Pezeshk, Mehdi Sadeghi   +6 more
doaj   +1 more source

Homologs of the Escherichia coli F Element Protein TraR, Including Phage Lambda Orf73, Directly Reprogram Host Transcription

mBio, 2022
Bacterial cells and their associated plasmids and bacteriophages encode numerous small proteins of unknown function. One example, the 73-amino-acid protein TraR, is encoded by the transfer operon of the conjugative F plasmid of Escherichia coli.
Saumya Gopalkrishnan, Wilma Ross, Madeline S. Akbari, Xintian Li, James R. J. Haycocks, David C. Grainger, Donald L. Court, Richard L. Gourse   +7 more
doaj   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting

Molecular Systems Biology, 2012
Viral infection depends on a complex interplay between host and viral factors. Here, we link host susceptibility to viral infection to a network encompassing sulfur metabolism, tRNA modification, competitive binding, and programmed ribosomal ...
Nathaniel D Maynard, Derek N Macklin, Karla Kirkegaard, Markus W Covert   +3 more
doaj   +1 more source

Stochastic Cell Fate and Longevity of Offspring

Cell Journal, 2017
Objective: Cellular decision-making is a key process in which cells with similar genetic and environmental background make dissimilar decisions. This stochastic process, which happens in prokaryotic and eukaryotic cells including stem cells, causes ...
Faezeh Dorri, Hamid Pezeshk, Mehdi Sadeghi   +2 more
doaj   +1 more source

Production of recombinant human granulocyte‐macrophage colony‐stimulating factor in thermoinducible E. coli: Tuning inclusion body architecture and protein yield via dissolved oxygen control

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil, Norma A Valdez‐Cruz, Sara Restrepo‐Pineda, Nuria Sánchez‐Puig, Rafael Vázquez‐Duhalt, Rubén D Cadena‐Nava, Néstor O Pérez, Mauricio A Trujillo‐Roldán   +7 more
wiley   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source

Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda’s fitness landscape and enables speciation

Nature Communications
A major challenge in evolutionary biology is explaining how populations navigate rugged fitness landscapes without getting trapped on local optima.
Michael B. Doud, Animesh Gupta, Victor Li, Sarah J. Medina, Caesar A. De La Fuente, Justin R. Meyer   +5 more
doaj   +1 more source

Bacteriophage Lambda as a Cloning Vector

Microbiological Reviews, 1993
[This corrects the article on p. 582 in vol. 56.].
openaire   +2 more sources

Large‐Scale Structural Dynamics in the Tail Fiber Modulate the Infective Transition of the T7 Bacteriophage

Small, EarlyView.
During host recognition, the fibers of T7 bacteriophages transition from a capsid bound state to an extended conformation, which requires some level of fiber flexibility. By using high‐speed atomic force microscopy, we show that the fibers have an internal molecular hinge and a torsionally compliant coiled‐coil region.
Luca Elizabet Kosik, Miklós Cervenak, Dominik Sziklai, Andrea Balogh‐Molnár, Negar Rahimi, Bence Fehér, Soma Yamamoto, Hiroki Konno, Noriyuki Kodera, Holger Flechsig, Romain Amyot, Heinz Amenitsch, Hedvig Tordai, Levente Herényi, Ana Cuervo, Miklós Kellermayer, Bálint Kiss   +16 more
wiley   +1 more source