Results 191 to 200 of about 50,190 (266)

Phage Therapy in Combating Multidrug-Resistant Gram-Negative Pathogens: A Scoping Review. [PDF]

Pharmaceuticals (Basel)
Sukri A, Lopes BS, Hanafiah A.
europepmc   +1 more source

A guide to the ecological limitations of phage therapy of bacterial biofilms: Is what's best for the phage best for the physician?

The FEBS Journal, EarlyView.
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley   +1 more source

Characterization of broad-host-range bacteriophages targeting multidrug-resistant E. coli and Shigella spp.: in vitro potential. [PDF]

BMC Microbiol
Mangieri N, Gaufin T, Ghatbale P, Pride DT, Picozzi C.   +4 more
europepmc   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Genome characterization of <i>Salmonella enterica</i> serovar Enteritidis phage SESL from a Malaysian hot spring salt lick. [PDF]

Microbiol Resour Announc
Tan YF, Mutusamy P, Sicheritz-Ponten T, Petersen B, Thevan K, Rajandas H, Parimannan S.   +6 more
europepmc   +1 more source

Microbiome and Pathobiome Characterization in Farmed Barramundi (Lates calcarifer) During and Post Scale Drop Disease Outbreaks

Journal of Fish Diseases, EarlyView.
ABSTRACT Large‐scale double‐digest RAD sequencing (ddRADseq) datasets generated for genotyping are increasingly available in aquaculture, yet their unmapped reads remain largely unexplored for pathogen surveillance. Here, we evaluated the utility and limitations of repurposing unmapped ddRADseq reads to examine pathogen‐associated and disease ...
Nguyen Thanh Vu, Xueyan Shen, Susan Gibson‐Kueh, Maura Carrai, Celestine Terence, Zhi Weng Josiah Poon, Sarah Priyanka Nelson, Saengchan Senapin, Ha Thanh Dong, Jiun‐Yan Loh, Dean R. Jerry, Jose A. Domingos   +11 more
wiley   +1 more source

ICP1 bacteriophage treatment antagonizes colonization of the zebrafish larval intestine by <i>Vibrio cholerae</i>. [PDF]

Microbiol Spectr
Sidi Mabrouk A, Depelteau JS, Foini C, Kempff A, Jonker S, Brenzinger S, Limpens R, Majrouh M, Meijer AH, Briegel A.   +9 more
europepmc   +1 more source

Innovative Field Applications of Probiotics, Prebiotics, and Medicinal Plant Products for Disease Control in Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Disease outbreaks and the associated reliance on antibiotics pose major constraints to the sustainability of modern aquaculture. As regulatory pressures increase and consumer demand shifts toward residue‐free production, diverse biological interventions are gaining prominence as viable alternatives to chemotherapeutics.
Mustafa Öz, Enes Üstüner, Sümmani Çifci, Suat Dikel, Emin İleri, Furkan Budak   +5 more
wiley   +1 more source

Complete genome sequence of <i>Escherichia coli</i> phage vB_EcoP_EcoN5 isolated from Magdalena River, Atlántico, Colombia. [PDF]

Microbiol Resour Announc
Lozano-Solano D, Arquez-Mendoza M, Quiñones-Vásquez S, Florez-Osorio C, Quiroz N, Solano C, Acosta-Hoyos AJ.   +6 more
europepmc   +1 more source

Enhanced exonuclease–Cas9 systems promote multiple nucleotide deletions with higher efficiency and broader targeting scope in plants

Journal of Integrative Plant Biology, EarlyView.
Cas9 preferentially generates small indels. By tethering an exonuclease and a DNA‐binding domain (DBD) to Cas9, the Exo‐DBD‐Cas9 system efficiently promotes multiple nucleotide deletions. These expanded deletions enable effective disruption of miRNA‐mediated regulation and relieve translational repression through targeted editing of 3′ untranslated ...
Rui Zhang, Xu Tang, Yao He, Wei Wang, Qiurong Ren, Yiping Qi, Yong Zhang   +6 more
wiley   +1 more source