Results 191 to 200 of about 49,896 (264)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

CRISPR spacer profiling and prophage mining reveal diverse bacteriophages associated with <i>Streptococcus Mutans</i>. [PDF]

J Oral Microbiol
Chen X, Zhang M, Yang L, Chen Y, Chi Y, Zhao Y, Ma Z, Li Y, Wang X.   +8 more
europepmc   +1 more source

Glycolytic metabolism of CD8+ T‐cells affects susceptibility to human leukocyte antigen‐mediated abacavir‐induced hypersensitivity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Drug hypersensitivity reactions (DHRs) associated with a specific human leukocyte antigen (HLA) allotype do not manifest uniformly in all individuals within an HLA model population. This scenario highlights the complexity of predicting drug hypersensitivity reaction risk without considering additional factors ...
Takeshi Susukida, Yuchen Sun, Noriaki Arakawa, Takuya Hirao, Tadahaya Mizuno, Shigeki Aoki, Kousei Ito, Yoshihiro Hayakawa   +7 more
wiley   +1 more source

Antibacterial Efficacy of <i>Pseudomonas aeruginosa</i> Bacteriophages on a <i>Drosophila</i> Infection Model. [PDF]

Pathogens
Petrzik K, Brázdová S.
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Erratum for Levesque et al., "Complete genome sequence of bacteriophages Merry and Sunny infecting <i>Microbacterium chocolatum</i> strain GAI20246-6 isolated from an outdoor commercial algal pond". [PDF]

Microbiol Resour Announc
Levesque AV, Rabines AJ, Alrubaiaan E, Oliver A, Allen EE, Hazlebeck D, Pinowska A, Traller JC, Zeigler Allen L.   +8 more
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Complete genome sequence of a <i>Streptococcus equi</i> subsp. <i>equi</i> bacteriophage isolated from raw sewage water in Tokyo. [PDF]

Microbiol Resour Announc
Shirakawa K, Kawamoto K, Kondo K, Ojima S, Kinoshita Y, Niwa H, Kataoka M, Suzuki T, Ueno T, Sugawara Y, Watashi K, Sugai M, Kiga K, Sato'o Y.   +13 more
europepmc   +1 more source

Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources

The FEBS Journal, EarlyView.
This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani, Marco Gargiulo, Elia Lio, Enrico Mario Alessandro Fassi, Giovanni Grazioso, Maria Assunta Chiacchio, Barış Binay, Stefania Brocca, Francesco Secundo   +8 more
wiley   +1 more source

Gut Virome Characteristics and Network Alterations in IgA Nephropathy. [PDF]

Kidney Int Rep
Wang X, Wang H, Liu J, Zhang H, Zhou XJ.
europepmc   +1 more source