Cost of parasite exposure depends on host ontogeny 寄生接觸的代價依賴於宿主發育階段
Ecological Entomology, EarlyView.The cost of parasite exposure varies across host developmental stages, demonstrating that ontogeny influences the expression of non‐consumptive effects (NCEs). Mite exposure resulted in consumptive effects in fly eggs and NCEs in early‐stage pupae; mite longevity was comparable when provisioned with pupae or water but increased when provisioned with ...
Lisa R. MacLeod +2 more
wiley +1 more source
Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein
The FEBS Journal, EarlyView.Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley +1 more source
Comparative morphological, genomic, and functional characterization of two newly isolated lytic caudoviricetes phages targeting Escherichia coli and Salmonella. [PDF]
Sci RepShaaban MT +6 more
europepmc +1 more source
The FEBS Journal, EarlyView.Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova +5 more
wiley +1 more source
Bacteriophage Therapy Against <i>Shigella</i> spp.: A Precision Antimicrobial Strategy. [PDF]
Antibiotics (Basel)Scarlata GGM +5 more
europepmc +1 more source
The FEBS Journal, EarlyView.The biosynthesis of bilins, tetrapyrroles essential for light harvesting and sensing, is performed by specific enzymes (FDBRs). In Galdieria sulphuraria, both phycobiliprotein types bind phycocyanobilin, despite lacking the canonical synthesizing gene PCYA. Instead, PEBA and PEBB are encoded, producing phycoerythrobilin, proposed to be later isomerized
Federica Frascogna +4 more
wiley +1 more source
Genome sequence of <i>Pseudomonas aeruginosa</i> bacteriophage. [PDF]
Microbiol Resour AnnouncIbrahim R, Lewis SA, Aranjani JM.
europepmc +1 more source
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources
The FEBS Journal, EarlyView.This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani +8 more
wiley +1 more source
Combination of bacteriophage and antibiofilm compounds from phyllosphere bacteria as a comprehensive strategy for aquaculture and food pathogen control. [PDF]
Sci RepMay J, Waturangi DE, Tan WA, Nurhasanah.
europepmc +1 more source