Results 221 to 230 of about 94,356 (310)

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Bacteriophages in gut metagenomes: from analysis to application. [PDF]

Virol J
Zakharevich N, Strokach A, Shitikov E, Klimina K.   +3 more
europepmc   +1 more source

Potential of the Predatory Mites Gamasellodes lavafesii (Mesostigmata: Ascidae) and Cosmolaelaps mediocuspis (Mesostigmata: Laelapidae) on Different Soil Pests/Parasites and Alternative Prey for Large‐Scale Rearing

Journal of Applied Entomology, EarlyView.
ABSTRACT Many species of Mesostigmata soil mites have potential as biological control agents of pests/parasites. This study evaluated the predation potential of two of these species, Gamasellodes lavafesii (Ascidae) and Cosmolaelaps mediocuspis (Laelapidae).
A. R. A. Barros, J. P. I. Martin, G. J. Moraes, M. M. Inomoto, R. C. Castilho   +4 more
wiley   +1 more source

<i>In vitro</i> efficacy of antibiotics and bacteriophages against <i>Pseudomonas aeruginosa</i> isolates from clinically affected captive falcons in Dubai, United Arab Emirates. [PDF]

One Health
Hebel C, Bailey T, Kalbhenn EM, Paterson GK, Wernery U.   +4 more
europepmc   +1 more source

Bacteriophage [PDF]

, 2020
openaire   +1 more source

Phage Therapy: Targeting the Gut Microbiota for the Treatment of Acute Pancreatitis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Acute pancreatitis (AP) is a common clinical inflammatory condition whose severity is closely associated with both local pancreatic injury and systemic complications. Research indicates that gut microbiota dysbiosis and subsequent bacterial translocation can exacerbate disease progression via the gut–pancreas axis, representing a critical ...
Jiawei Chen, Caihan Duan, Keyi Zhang, Jun Liu, Chaoqun Han   +4 more
wiley   +1 more source

Genome Sequence of Bacteriophages Bouchard and Windest Isolated Using <i>Arthrobacter globiformis</i> B-2979. [PDF]

MicroPubl Biol
Marcum T, Racine C, Johnson K, Hildebrand T, Patton J.   +4 more
europepmc   +1 more source

Enhanced exonuclease–Cas9 systems promote multiple nucleotide deletions with higher efficiency and broader targeting scope in plants

Journal of Integrative Plant Biology, EarlyView.
Cas9 preferentially generates small indels. By tethering an exonuclease and a DNA‐binding domain (DBD) to Cas9, the Exo‐DBD‐Cas9 system efficiently promotes multiple nucleotide deletions. These expanded deletions enable effective disruption of miRNA‐mediated regulation and relieve translational repression through targeted editing of 3′ untranslated ...
Rui Zhang, Xu Tang, Yao He, Wei Wang, Qiurong Ren, Yiping Qi, Yong Zhang   +6 more
wiley   +1 more source

Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health. [PDF]

World J Virol
Saeed NK, Elbeltagi YM, Al-Beltagi M.
europepmc   +1 more source

Synergistic engineering of Casδ nuclease for robust genome editing

Journal of Integrative Plant Biology, EarlyView.
A hierarchical engineering strategy was used to enhance the editing activity of Casδ, yielding an optimized variant termed enCasδ. This variant enables robust genome editing in animal cells and plants, with overall editing performance comparable to that of SpCas9 and other Cas12 nucleases.
Fanghui Ge, Chenchen Peng, Yang Du, Ying Chen, Zilong Zhao, Meixia Yu, Huairu Feng, Yuyang Xie, Siwei Sun, Shengnan Liu, Beibei Xin, Haiming Zhao, Sen Wu, Chao Bian, Zhijia Yang, Jinsheng Lai, Jian Chen   +16 more
wiley   +1 more source