Results 201 to 210 of about 94,356 (310)

Phages as antimicrobials against multi-drug resistant bacteria. [PDF]

Front Microbiol
Plat S, LaPointe G, Goodridge L.
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Effect of bacteriophages on growth performance and health indicators in broiler chickens in the absence of bacterial challenge - A review. [PDF]

Vet Med (Praha)
Shaufi MAM, Chia SL, Hassim HA, Yusof MT, Akbar MA, Song AA, Mustafa S.   +6 more
europepmc   +1 more source

Glycolytic metabolism of CD8+ T‐cells affects susceptibility to human leukocyte antigen‐mediated abacavir‐induced hypersensitivity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Drug hypersensitivity reactions (DHRs) associated with a specific human leukocyte antigen (HLA) allotype do not manifest uniformly in all individuals within an HLA model population. This scenario highlights the complexity of predicting drug hypersensitivity reaction risk without considering additional factors ...
Takeshi Susukida, Yuchen Sun, Noriaki Arakawa, Takuya Hirao, Tadahaya Mizuno, Shigeki Aoki, Kousei Ito, Yoshihiro Hayakawa   +7 more
wiley   +1 more source

Complete genome sequence of the phage UNICOR_HM-QL, a <i>Berlinviru</i>s infecting <i>Escherichia coli</i> and <i>Salmonella</i> with potential for biocontrol in milk for Costeño cheese production. [PDF]

Microbiol Resour Announc
Mendoza-Corvis F, Vidigal PMP, Hungaro HM, Perez Sierra O, Hernández Arteaga AM, Soto Lopez ME.   +5 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Encapsulation of Bacteriophages in Alginate Beads: Improved Viability Under Harsh Simulated Gastric and Intestinal Conditions for Phage Therapy Applications. [PDF]

Pharmaceuticals (Basel)
Almekhlafi SA, Farrag MA, Al-Wahibi MS, Al-Rashed S, Almaarik BM, Marraiki NAY.   +5 more
europepmc   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Anthropogenic Disruption Versus Natural Restoration: Enterobacter cloacae-Driven Barnacle Larval Settlement and Its Mitigation via Natural Bacteriophages. [PDF]

Microb Biotechnol
Khan A, Saha A, Joshi HM.
europepmc   +1 more source

Mining the virome for insights into type 1 diabetes [PDF]

, 2018
Park, Arnold, Zhao, Guoyan
core   +2 more sources