Results 121 to 130 of about 39,241 (241)

Stricturing Diseases of the Gastrointestinal Tract—Current Clinical Practice

JGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Gastrointestinal stricture can occur in the esophagus, stomach, small intestine, colon, and anorectum. Most of the strictures are benign. The prevalence of esophageal strictures (ES) secondary to eosinophilic esophagitis has increased. Pyloric stenosis (PS) is rarely seen in clinical practice.
Monjur Ahmed
wiley   +1 more source

Bioluminescence Imaging to Track Bacteroides fragilis Inhibition of Vibrio parahaemolyticus Infection in Mice

Frontiers in Cellular and Infection Microbiology, 2017
Bacteroides fragilis is an anaerobic, Gram-negative, commensal bacterium of the human gut. It plays an important role in promoting the maturation of the immune system, as well as suppressing abnormal inflammation.
Zhengchao Li, Zhengchao Li, Huimin Deng, Huimin Deng, Yazhou Zhou, Yafang Tan, Xiaoyi Wang, Yanping Han, Yangyang Liu, Ye Wang, Ruifu Yang, Yujing Bi, Fachao Zhi   +12 more
doaj   +1 more source

Tn‐seq of Thermus thermophilus Genome Reveals Unexpected Tolerance to Insertions in Bacterial Common Essential Genes

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Tn‐seq analysis of Thermus thermophilus genome reveals insertions in almost all genes, this is, there is no clear discrimination of essential genes. A similar result has not been reported in other Tn‐seq analysis of bacterial genomes so far. The polyploidy of the Thermus genome could explain the apparent non‐essentiality of key genes.
Cristina L. Gómez‐Campo, Marc Gost, Bruna Fernanda Silva de Sousa, Laura Álvarez, José Berenguer, Modesto Redrejo‐Rodríguez, Mario Mencía   +6 more
wiley   +1 more source

Ionomycin Exhibits Potent and Selective Bactericidal Activity Against Clostridioides difficile Through Calcium‐Dependent Membrane Disruption

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Ionomycin exhibits potent and selective bactericidal activity against Clostridioides difficile, rapidly reducing vegetative cells, toxin production, sporulation, and spore germination while sparing representative gut microbiota. Its activity is calcium‐dependent and mediated through disruption of bacterial membrane potential, highlighting ionomycin as ...
Ahmed A. Abouelkhair, Nader S. Abutaleb, Mohamed N. Seleem   +2 more
wiley   +1 more source

Therapeutic Remodeling of the Gut Microbiome as a Strategy to Restore Immune Tolerance in Autoimmunity

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This graphical abstract illustrates how altered gut microbiota lead to autoimmunity. It shows that gut dysbiosis causes a “leaky gut” and activates autoreactive intestinal immune cells, which then migrate to other organs, ultimately triggering systemic autoimmune responses.
Behshad Boroumand, Amirhossein Jaberi, Ghazal Zamani, Ehsan Zandi, Farshad Zare, Milad Vahedinezhad, Elham Abdollahi, Sepideh KarkonShayan, Sasan GhazanfarAhari, Mustafa Sattar   +9 more
wiley   +1 more source

Multiomics Research Strategies in Cancer: A Growing and Innovative Field

MedComm, Volume 7, Issue 4, April 2026.
This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du, Xiaomei Liu, Zhi Lv, Bengang Wang, Yu Xia, Wala Abduljabbar Mohammed Al‐Duais, Lirong Yan, Fuqiang Zhang, Yanke Li   +8 more
wiley   +1 more source

Transglycosylation Capabilities of Wild‐Type α‐l‐Fucosidase iso1 from Paenibacillus thiaminolyticus and Its Engineered Mutants: Preparation of Fucosylated Oligosaccharides

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Several point mutations were introduced into the α‐l‐fucosidase iso1 from Paenibacillus thiaminolyticus (α‐l‐f1Pth‐wt) to enhance its transfucosylation activity. The S237V variant (α‐l‐f1Pth‐S237V) demonstrated superior regioselectivity in the synthesis of 3′‐and 6′‐fucosyllactose and functionalized 3′‐fucosyllactose bearing a Boc‐protected ...
Patricie Vodičková, Lucie Klimešová, Pavlína Nekvasilová, Lucie Petrásková, Helena Pelantová, Terézia Kovaľová, Petra Lipovová, Pavla Bojarová, Eva Benešová   +8 more
wiley   +1 more source

Unveiling the mysteries: Functional insights into hypothetical proteins from Bacteroides fragilis 638R

Heliyon
Humans benefit from a vast community of microorganisms in their gastrointestinal tract, known as the gut microbiota, numbering in the tens of trillions. An imbalance in the gut microbiota known as dysbiosis, can lead to changes in the metabolite profile,
Thomas Jebastin, M.H. Syed Abuthakir, Ilangovan Santhoshi, Muniraj Gnanaraj, Mansour K. Gatasheh, Anis Ahamed, Velusamy Sharmila   +6 more
doaj   +1 more source

Microbiota and clinical outcomes of implant‐supported full‐mandible dentures on patients with a history of periodontitis: A 5‐year prospective cohort study

Journal of Prosthodontics, Volume 35, Issue 4, Page 478-487, April 2026.
Abstract Purpose To characterize the microbiota of implant‐supported full‐mandible dentures and its correlation to clinical outcomes for up to 5 years after implant loading in patients with a history of periodontal disease. Materials and Methods Twelve individuals with a history of periodontitis (Stage IV and Grade B) received five immediate implants ...
Jefferson Antônio Gomes, Yumi Chokyu Del‐Rey, Alice Ramos de Freitas, Ivete Aparecida de Mattias Sartori, Cássio do Nascimento   +4 more
wiley   +1 more source

Gut microbes–spinal connection is required for itch sensation

Gut Microbes
The gut microbiota has been linked to a number of neurological disorders. However, it is unclear whether the gut microbiota is involved in the genesis of chronic itch, a refractory condition that afflicts patients both physically and mentally.
Tong Jin, Si-Yuan Li, Hong-Li Zheng, Xiao-Dan Liu, Yue Huang, Gan Ma, Ya-Xuan Zhao, Xiao-Tian Zhao, Li Yang, Qi-Hui Wang, Hong-Jun Wang, Chengyong Gu, Zhiqiang Pan, Fuqing Lin   +13 more
doaj   +1 more source