Phenotypic assay for cytotoxicity assessment of Balamuthia mandrillaris against human neurospheroids [PDF]
Frontiers in Microbiology, 2023 IntroductionThe phenotypic screening of drugs against Balamuthia mandrillaris, a neuropathogenic amoeba, involves two simultaneous phases: an initial step to test amoebicidal activity followed by an assay for cytotoxicity to host cells.
Narisara Whangviboonkij +7 more
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Balamuthia mandrillaris encephalitis in an uncontrolled diabetic patient [PDF]
IDCases, 2021 Balamuthia mandrillaris is a free-living amoeba that may result in a disseminated infection of the central nervous system called granulomatous amoebic encephalitis.
Valli Mani, Eric Hudgins
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Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline [PDF]
Emerging Infectious Diseases, 2023 A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline.
Natasha Spottiswoode +17 more
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The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design [PDF]
Scientific Reports, 2021 Balamuthia mandrillaris, a pathogenic free-living amoeba, causes cutaneous skin lesions as well as granulomatous amoebic encephalitis, a ‘brain-eating’ disease.
Isabelle Q. Phan +12 more
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Encephalomyelitis Caused by Balamuthia mandrillaris in a Woman With Breast Cancer: A Case Report and Review of the Literature [PDF]
Frontiers in Immunology, 2022 Balamuthia mandrillaris is one cause of a rare and severe brain infection called granulomatous amoebic encephalitis (GAE), which has a mortality rate of >90%. Diagnosis of Balamuthia GAE is difficult because symptoms are non-specific.
Juan Hu +10 more
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Imaging findings of Balamuthia mandrillaris amoebic encephalitis in 2 cases with different prognosis and literature review [PDF]
BMC NeurologyIntroduction Balamuthia mandrillaris amoebic encephalitis is a rare granulomatous amoebic encephalitis caused by infection with Balamuthia mandrillaris with a fatality rate over 90%.
Yanjia Chen, Tingting Zhang, Haiyan Lou
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Subacute encephalitis in an immunocompetent patient diagnosed by next-generation sequencing [PDF]
Journal of International Medical Research, 2022 Balamuthia mandrillaris is a free-living heterotrophic amoeba found in soil that causes a rare and usually fatal granulomatous amebic encephalitis. We report an immunocompetent patient infected with B.
Changbo Xu +5 more
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An Optical and Chemiluminescence Assay for Assessing the Cytotoxicity of Balamuthia mandrillaris against Human Neurospheroids [PDF]
Bioengineering, 2022 A spheroid is a cell aggregate in a three-dimensional context; thereby, it recapitulates the cellular architecture in human tissue. However, the utility of spheroids as an assay for host–parasite interactions remains unexplored.
Worakamol Pengsart, Kasem Kulkeaw
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Functional annotation and comparative genomics analysis of Balamuthia mandrillaris reveals potential virulence-related genes [PDF]
Scientific Reports, 2023 Balamuthia mandrillaris is a pathogenic protozoan that causes a rare but almost always fatal infection of the central nervous system and, in some cases, cutaneous lesions. Currently, the genomic data for this free-living amoeba include the description of
Alejandro Otero-Ruiz +6 more
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Balamuthia mandrillaris infection in China: a retrospective report of 28 cases [PDF]
Emerging Microbes and Infections, 2020 Balamuthia mandrillaris infection is a rare and fatal disease. We have recorded 28 cases of Balamuthia mandrillaris infection during the past 20 years. Eighteen patients (64%) were male and 10 (36%) were female. Patient age ranged from 3 to 74 (mean, 27)
Lei Wang +14 more
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