Results 51 to 60 of about 1,736 (178)

Balamuthia mandrillaris: Morphology, biology, and virulence

Tropical Parasitology, 2015
Balamuthia mandrillaris is a protist pathogen that can cause encephalitis with a fatality rate of >95%. This is due to our incomplete understanding of the pathogenesis and pathophysiology of B. mandrillaris encephalitis. B. mandrillaris has two stages in its life cycle, an active trophozoite stage during which it divides mitotically.
Siddiqui, Ruqaiyyah, Khan, Naveed Ahmed
openaire   +3 more sources

Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris

mBio, 2018
Balamuthia mandrillaris is a pathogenic free-living amoeba that causes a rare but almost always fatal infection of the central nervous system called granulomatous amoebic encephalitis (GAE). Two distinct forms of B.
Matthew T. Laurie, Corin V. White, Hanna Retallack, Wesley Wu, Matthew S. Moser, Judy A. Sakanari, Kenny Ang, Christopher Wilson, Michelle R. Arkin, Joseph L. DeRisi   +9 more
doaj   +1 more source

Balamuthia mandrillaris en el Perú, lesiones cutáneas, meningoencefalitis y métodos de cultivo

Infectio
Las amebas de vida libre son microorganismos abundantes en el suelo y agua en todo el planeta. Algunas especies de estas amebas son capaces de causar muerte en el ser humano y animales, asi como Naegleria fowleri (N. fowleri), Acanthamoeba sp.
Alfonso Martín Cabello-Vílchez
doaj   +1 more source

Isolation and genotyping of Acanthamoeba strains from corneal infections in Italy [PDF]

, 2010
Acanthamoeba keratitis (AK) is a corneal disease caused by members of a genus of free-living amoebae and is associated predominantly with contact lens (CL) use. This study reports 16 cases of culture-proven AK diagnosed in northern Italy.
Berrilli, F, Bruno, A, Carletti, S, Cavallero, A, DI CAVE, D, Gatti, S, Maserati, R, Matuska, S, Rama, P   +8 more
core   +3 more sources

Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia. [PDF]

, 2019
The free-living amebae Naegleria, Acanthamoeba, and Balamuthia cause rare but life-threatening infections. All three parasites can cause meningoencephalitis.
Chen, Emily, Debnath, Anjan, Ehrenkaufer, Gretchen, Kangussu-Marcolino, Monica, Singh, Upinder   +4 more
core   +1 more source

Amebic Encephalitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy

Case Reports in Hematology, Volume 2018, Issue 1, 2018., 2018
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western countries. A common first‐line therapy offered to qualifying patients includes ibrutinib, an oral covalent inhibitor of Bruton’s tyrosine kinase. Treatment of CLL with ibrutinib therapy is generally well tolerated; however, serious opportunistic infections are being ...
Ensi Voshtina, Huiya Huang, Renju Raj, Ehab Atallah, Kiyotaka Kawauchi   +4 more
wiley   +1 more source

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae.

PLoS Neglected Tropical Diseases, 2020
Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis (Acanthamoeba spp.), Acanthamoeba keratitis, and Balamuthia amoebic encephalitis (Balamuthia ...
Christopher A Rice, Beatrice L Colon, Emily Chen, Mitchell V Hull, Dennis E Kyle   +4 more
doaj   +1 more source

In Vitro Activity of Nitroxoline (5‐Nitro‐8‐Hydroxyquinoline) Against Aspergillus Species

Mycoses, Volume 68, Issue 11, November 2025.
ABSTRACT Background Nitroxoline is an old antibiotic currently approved for the treatment of uncomplicated urinary tract infections. Its mode of action is based on the chelation of bivalent cations, such as zinc. Objectives As zinc plays a central role in the metabolism of Aspergillus spp., we performed antifungal susceptibility testing against ...
Ada Hoffmann, Oliver A. Cornely, Jana Vonhoegen, Rosanne Sprute, Ilana Reinhold, Grit Walther, Frieder Fuchs, Michaela Simon   +7 more
wiley   +1 more source

Xenic Cultivation and Genotyping of Pathogenic Free‐Living Amoeba from Public Water Supply Sources in Uganda

New Journal of Science, Volume 2016, Issue 1, 2016., 2016
Studies on waterborne parasites from natural environment and domestic water sources in Uganda are very scarce and unpublished. Water dwelling free‐living amoebae (FLA) of the genus Acanthamoeba, Hartmannella, and Naegleria are often responsible for causing morbidities and mortalities in individuals with recent contact with contaminated water, but their
Celsus Sente, Joseph Erume, Irene Naigaga, Benigna Gabriela Namara, Julius Mulindwa, Sylvester Ochwo, Phillip Kimuda Magambo, Charles Drago Kato, Andrew Tamale, Michael Ocaido, Xinhua Shu   +10 more
wiley   +1 more source

Stress Management in Cyst‐Forming Free‐Living Protists: Programmed Cell Death and/or Encystment

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
In the face of harsh conditions and given a choice, a cell may (i) undergo programmed cell death, (ii) transform into a cancer cell, or (iii) enclose itself into a cyst form. In metazoans, the available evidence suggests that cellular machinery exists only to execute or avoid programmed cell death, while the ability to form a cyst was either lost or ...
Naveed Ahmed Khan, Junaid Iqbal, Ruqaiyyah Siddiqui, Philippe Holzmuller   +3 more
wiley   +1 more source