Results 81 to 90 of about 128,512 (289)
A geographically distributed bio-hybrid neural network with memristive plasticity [PDF]
, 2017 Throughout evolution the brain has mastered the art of processing real-world inputs through networks of interlinked spiking neurons. Synapses have emerged as key elements that, owing to their plasticity, are merging neuron-to-neuron signalling with ...
Corna, Andrea +10 more
core +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Inverse topology in BL-algebras
پژوهشهای ریاضی, 2020 In this paper, we introduce Inverse topology in a BL-algebra A and prove the set of all minimal prime filters of A, namely Min(A) with the Inverse topology is a compact space, Hausdorff, T0 and T1-Space.
Fereshteh Forouzesh +2 more
doaj
Word formation in contemporary Liangmai: A morphological study [PDF]
, 2019 This paper attempts to discuss the different processes of word formation in contemporary Liangmai, a Tibeto-Burman (TB) language of the Kuki-Chin-Naga sub group (Bradley 1997).
Daimai, Kailadbou
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM
Nature Communications, 2021 The β-barrel assembly machinery (BAM) assists the folding and membrane insertion of bacterial outer membrane proteins. Here, the authors report structural characterization of BAM in lipid environment and in complex with the client protein EspP integrated
Runrun Wu +12 more
doaj +1 more source
The Reconstituted Escherichia coli Bam Complex Catalyzes Multiple Rounds of β-Barrel Assembly [PDF]
Biochemistry, 2011 β-Barrel proteins are folded and inserted into the outer membranes of Escherichia coli by the Bam complex. The Bam complex has been purified and functionally reconstituted in vitro. We report conditions for reconstitution that increase the folding yield 10-fold and allow us to monitor the time course of folding directly.
Christine L, Hagan, Daniel, Kahne
openaire +2 more sources
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2022 The outer membrane of Gram-negative bacteria acts as an additional diffusion barrier for solutes and nutrients. It is perforated by outer membrane proteins (OMPs) that function most often as diffusion pores, but sometimes also as parts of larger cellular
Simen Hermansen +5 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source