Results 91 to 100 of about 13,919 (205)

Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma [PDF]

, 2023
More than half of patients with malignant mesothelioma show alterations in the BAP1 tumor-suppressor gene. Being a member of the Polycomb repressive deubiquitinating (PR-DUB) complex, BAP1 loss results in an altered epigenome, which may create new ...
van Lohuizen, Maarten, Beijersbergen, Roderick, Pandey, Gaurav Kumar, Landman, Nick, Janes, Sam M, Badhai, Jitendra, Hulsman, Danielle, Neikes, Hannah K, Kolluri, Krishna Kalyan, Vermeulen, Michiel, Lieftink, Cor   +10 more
core   +1 more source

Tissue-specific significance of BAP1 gene mutation in prognostic prediction and molecular taxonomy among different types of cancer

Tumor Biology, 2017
BAP1 is an emerging tumor suppressor whose inactivating mutations have been found to play critical roles in tumor development. This study was conducted to elucidate the potential value of BAP1 mutation in guiding prognostic prediction and clinical ...
Xiang-Yu Wang, Zheng Wang, Jian-Bo Huang, Xu-Dong Ren, Dan Ye, Wen-Wei Zhu, Lun-Xiu Qin   +6 more
doaj   +1 more source

BRCA1-Associated Protein 1 and Its Role of Cell Cycle Regulation in Cancer

Journal of Tropical Life Science
BRCA1-associated protein 1 (BAP1) plays a critical role in regulating the cell cycle, exhibiting both tumor-suppressive and oncogenic roles. It controls the expression and stability of key cell cycle regulators, including cyclin D1, p27, and Krüppel-like
Syarifuddin Husain, Ruzianisra Mohamed, Khairul Bariyyah Abd Halim, Siti Syairah Mohd Mutalip   +3 more
doaj   +1 more source

Histomorphologic spectrum of BAP1 negative melanocytic neoplasms in a family with BAP1‐associated cancer susceptibility syndrome

Journal of Cutaneous Pathology, 2015
BackgroundMultiple BAP1 negative melanocytic neoplasms are a hallmark of familial cancer susceptibility syndrome caused by BAP1 germline mutation. The syndrome is characterized by increased incidence of renal cell carcinoma, mesothelioma, cholangiocarcinoma, cutaneous and uveal melanoma and some other neoplasms.MethodsWe report histomorphologic ...
Marušić, Zlatko, Buljan, Marija, Busam, Klaus J   +2 more
openaire   +2 more sources

Establishing BAP1 iKO AD293 cell lines by using CRISPR/Cas9

, 2017
Als Wiesner Naevus bezeichnet wird ein melanozytärer Tumor, der mit einer heterozygoten Keimbahnmutation im BAP1-Gen einhergeht. Diese melanozytären Neoplasien dienen als klinischer Marker um Patienten mit autosomal dominanten BAP1-Keimbahnmutationen zu ...
Ledam, Romana
core   +1 more source

Comparison of Germline versus Somatic BAP1 Mutations for Risk of Metastasis in Uveal Melanoma

BMC Cancer, 2018
Background Germline mutations in BAP1 have been associated with BAP1-Tumor Predisposition Syndrome (BAP1-TPDS), a predisposition to multiple tumors within a family that includes uveal melanoma (UM), cutaneous melanoma, malignant mesothelioma and renal ...
K. G. Ewens, E. Lalonde, J. Richards-Yutz, C. L. Shields, A. Ganguly   +4 more
doaj   +1 more source

BAP1 cytoplasmic staining and LOH in MM biopsies.

, 2015
(A) Representative histology (Hematoxylin and Eosin staining) and BAP1 IHC. Controls: Panel a, normal strip of pleural mesothelial cells; d, MM biopsy containing wild-type BAP1.
Michael Minaai (838996), Peter Bryant-Greenwood (838998), Sandra Pastorino (282716), Tatsuhiko Tsunoda (128303), Michele Carbone (130335), Harriet Hoffman (838991), Todd A. Johnson (453651), Amy Powers (838995), Mitsuru Emi (838989), Francine Baumann (838997), Giovanni Gaudino (419365), Michaela B. Kirschner (207215), Mary Hesdorffer (838992), Harvey I. Pass (130345), Erin G. Flores (838988), Haining Yang (839000), Isabelle Opitz (802092), Dusty Behner (838990), Masaki Nasu (838993), Andrea Napolitano (838994), Olivia Lauk (838999), Walter Weder (802091)   +21 more
core   +1 more source

Association of BAP1 polymorphisms with development of uveal melanoma

RUDN Journal of Medicine
Relevance. Uveal melanoma is a rare form of cancer that originates in the eye, most frequently arises in the choroid (90%). BAP1 is a tumor suppressor gene, mutations in this gene were found in 40-84% of primary UM.
Lujin Mukhana, Abdulbary Amin M. Ahmed, Olga O. Gigani, Svetlana V. Saakyan, Yu. Yu. Tsygankov Alexander, Madina M. Azova   +5 more
doaj   +1 more source

Additional file 3: of Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma

, 2018
Immunoblot to confirm knockdown of BAP1. Immunoblot of protein collected from the three independent experiments that were used for RNA-seq expressing control or BAP1-specific shRNAs in OCM-1A cells. Specific bands for BAP1 and GAPDH are indicated.
Xuhua Chen (5940107), Robi Mitra (5940110), Michael Onken (834122), Matthew Yen (5940104), John Cooper (274237), Zongtai Qi (2068426)   +5 more
core   +1 more source

BRCA-associated protein1 (BAP1) immunohistochemical stain reliability in postbrachytherapy uveal melanoma enucleation specimens

Indian Journal of Ophthalmology
Purpose: The BRCA-associated protein1 (BAP1) immunohistochemical (IHC) stain has emerged as a powerful and inexpensive prognostic tool in uveal melanoma (UM), correlating with UM genetics and outcome.
Maya Eiger-Moscovich, Carol L Shields, Ralph C Eagle Jr, Tatyana Milman   +3 more
doaj   +1 more source