Results 101 to 110 of about 13,919 (205)

The Role of Tumour Suppressors BAP1 and ASXL1 in Myelodysplasia

, 2014
Full text is available to authenticated members of The University of Auckland only.Myelodysplastic syndromes (MDS) are a heterogeneous group of haematologic disorders characterised by clonal expansion of bone marrow myeloid cells that is associated with ...
Tong, Yan
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Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains

, 2018
Deleterious mutations of the ubiquitin carboxy-terminal hydrolase BAP1 found in cancers are predicted to encode inactive truncated proteins, suggesting that loss of enzyme function is a primary tumorigenic mechanism. However, many tumors exhibit missense
Harbour, J. William, Bowcock, Anne M, Cheung, Mitchell, Li Cao, Rauscher, Frank J, Mitchell Cheung, Peng, Hongzhuang, Karar, Jayashree, Hongzhuang Peng, Malkowicz, S. Bruce, S. Bruce Malkowicz, Testa, Joseph R, Joseph R. Testa, Cao, Li, J. William Harbour, Park, Kyewon, Jeremy Prokop, Prokop, Jeremy, Jayashree Karar, Anne M. Bowcock, Kyewon Park, Frank J. Rauscher   +21 more
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BAP1 loss predicts longer survival for mesothelioma patients treated with pemetrexed-based chemotherapy

, 2020
BRCA1-associated protein 1 (BAP1) immunohistochemistry (IHC) was assessed as a predictive biomarker for pemetrexed-based treatment in non-surgically treated malignant pleural mesothelioma (MM) patients.IHC was performed on 168 MM patient slides to assess
Amber Louw, Andersen, Louise Lynggård, Louw, Amber, Szejniuk, Weronika Maria, Weronika Maria Szejniuk, Johnni Hansen, Louise Lynggård Andersen, Christos Meristoudis, Asghari, Azadeh Birbaneh, Panou, Vasiliki; id_orcid, Azadeh Birbaneh Asghari, Vyberg, Mogens, Szejniuk, Weronika Maria; id_orcid, Hansen, Johnni, Meristoudis, Christos, Birbaneh Asghari, Azadeh; id_orcid, Panou, Vasiliki, Lynggård Andersen, Louise, Chai, Siaw Ming, Mogens Vyberg, Jenette Creaney, Creaney, Jenette, Siaw Ming Chai, Vasiliki Panou, Oluf Dimitri Røe, Røe, Oluf Dimitri   +25 more
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First Report of BAP1 ‐Associated Polyposis

American Journal of Medical Genetics Part A
ABSTRACT BAP1 Tumor Predisposition Syndrome ( BAP1 ‐TPDS) is caused by germline pathogenic variants in the BAP1 gene and has been associated with uveal melanoma, mesothelioma, cutaneous melanoma, renal cell ...
Angela L. Jacobson, Maegan E. Roberts, Lindsey Byrne, Jenna Wolfe, Peter P. Stanich, Mohamed H. Abdel‐Rahman, Colin C. Pritchard, Eric Q. Konnick   +7 more
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Regulation of Med1 protein by overexpression of BAP1 in breast cancer cells

Molecular & Cellular Oncology
Med1 binds to a nuclear receptor and regulates transcription. Elevated Med1 protein expression promotes cancer growth in hormone-dependent breast and prostate cancers.
Hyunju Kim
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Unraveling the Prognostic Significance of BRCA1-Associated Protein 1 (BAP1) Expression in Advanced and Castrate-Resistant Prostate Cancer

Biology
Prostate cancer (PCa) is ranked as one of the top cancers affecting men in Western societies. BRCA1-associated protein 1 (BAP1) expression significance has been observed in various cancers, including prostate cancer.
Norel Salut, Yaser Gamallat, Sima Seyedi, Joema Felipe Lima, Sunita Ghosh, Tarek A. Bismar   +5 more
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CDK6/4 inactivates BAP1 deubiquitinase destabilizing VHL to promote metastatic colonization in liver

Molecular Cancer
Background Single organ metastasis to liver typically occurs in uveal melanoma (UM) and colorectal carcinoma (CRC). Colonization in the host organ is a beachhead step of the metastasis process.
Bei Jin, Luo Yang, Weijia Peng, Zhongwen Luo, Dong Wei, Jing Zhang, Li Zhao, Jinqiu Zhong, Qianyun Ye, Peirong Li, Ping Zhang, Li Liang, Jingxuan Pan   +12 more
doaj   +1 more source

BAP1 geenin UCH-domeinin missense-mutaatioiden entsymaattinen aktiivisuus

, 2022
Patogeeniset variantit BAP1 (BRCA-associated protein 1) geenissä aiheuttavat BAP1-kasvainalttiusoireyhtymää. Patogeenisen variantin takia kantajalla on suurentunut riski saada syöpä, kuten suonikalvoston melanoomaa (uvealmelanooma, UM).
Staskiewicz, Aleksandra
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FIGURE 6 from Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment

Expression of IL6 and IL10 in ascites and Bap1 and p16Ink4a in MM tumors from chrysotile-exposed Bap1+/− mice. A, Concentration of IL6 in ascites of Bap1+/− mice compared with that from Bap1+/+ mice with MMs induced by chrysotile.
Hatice U. Osmanbeyoglu (15032634), Joseph R. Testa (14934507), Parham Hadikhani (18327391), Eleonora Sementino (18327382), Yuwaraj Kadariya (18327379), Kathy Cai (18327394), Maggie Ruan (18327385), Mitchell Cheung (18327388), Andres J. Klein-Szanto (15359887)   +8 more
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An overview of BAP1 biological functions and current therapeutics

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene that was first identified in 1998. Germline loss-of-function variants in BAP1 are associated with a tumor predisposition syndrome with at least four cancers: uveal melanoma (UM), malignant mesothelioma (MMe), renal cell carcinoma (RCC), and cutaneous melanoma (CM).
Elsayed, Abdelrahman M., Kittaneh, Muaiad, Cebulla, Colleen M, Abdel-Rahman, Mohamed H.   +3 more
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