Acta Crystallographica Section E: Crystallographic Communications, 2015 The title molecular salt, C5H12NO+·C12H8N5O9− [common name: 4-methylmorpholin-4-ium 1,3-dimethyl-5-(2,4,6-trinitrophenyl)barbiturate], possesses noticeable anticonvulsant and hypnotic activity.
Jeganathan Gomathi +1 more
doaj +1 more source
Barbiturat dan Obat Pelumpuh Otot: Masih Bermanfaat untuk Menangani Hipertensi Intrakranial?
Jurnal Neuroanestesi Indonesia, 2013 Hipertensi intrakranial dapat menyebabkan cedera otak sekunder dan meningkatkan morbiditas serta mortalitas. Untuk mempertahankan tekanan intrakranial agar senantiasa dalam batas normal, maka cairan serebrospinal dan darah mempunyai kemampuan untuk ...
M. Sofyan Harahap
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Delayed post−hypoxic leukoencephalopathy following barbiturate overdose: A case report
Journal of Acute Disease, 2022 Rationale: Delayed post-hypoxic leukoencephalopathy (DPHL) is usually an overlooked condition, which arises as a result of a multitude of reversible and irreversible conditions.
Arshi Syal +4 more
doaj +1 more source
Allopregnanolone and Pentobarbital Infused Into the Nucleus Accumbens Substitute for the Discriminative Stimulus Effects of Ethanol [PDF]
, 2001 BACKGROUND: The discriminative stimulus effects of ethanol are mediated in part by the gamma-aminobutyric acid type A (GABA(A)) receptor system. We have previously shown that microinjections of the competitive GABA(A) agonist muscimol in the nucleus ...
Nannini, Michelle A. +4 more
core +1 more source
Barbiturate AEDS, EEG and Cognitive Performance
Pediatric Neurology Briefs, 1997 Neuropsychological performance and quantitative EEGs were studied in 11 epileptic children, aged 7 to 14 years, both during treatment and without phenobarbital and mephobarbital, and in comparison to 13 matched controls, at Tulane University Medical ...
J Gordon Millichap
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Therapeutic profile of antiepileptics in patients from the Wilaya of Batna. A retrospective study on 106 cases. [PDF]
Batna Journal of Medical SciencesIntroduction. Therapeutic monitoring of conventional antiepileptic drugs is an essential approach to optimize the management of epileptic patients.
Soumaya BOUDJEMAA +9 more
doaj +1 more source
Enamine Barbiturates and Thiobarbiturates as a New Class of Bacterial Urease Inhibitors
Applied Sciences, 2020 Urease is a therapeutic target associated with several important diseases and health problems. Based on our previous work on the inhibition of glucosidase and other enzymes and exploiting the privileged structure assigned to the (thio)barbiturate ...
M. Ali +9 more
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Effect of Local Anaesthetics on Barbiturate Sleeping Time
, 1959 The effect of certain local anaesthetics on barbiturate sleep in the mouse and the guinea pig is described. One of a series of new local anaesthetics 1-(1-methyl-2-phenylcarbamoylethyl)pyrrolidine (WS 10) prolongs barbiturate sleep in the guinea pig 2.3 ...
Edouard Frommel +2 more
core +1 more source
Sleep disorders related to index and comorbid mental disorders and psychotropic drugs
Annals of General Psychiatry, 2023 Purpose Mental disorders positively associate with sleep disorders. This study will explore the moderating influence of comorbid mental disorders and whether selected psychotropic drugs correlate with sleep disorders after adjusting for mental disorders.
Ray M. Merrill +2 more
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Zuranolone: A case study in (regulatory) rush to judgement?
British Journal of Clinical Pharmacology, EarlyView.Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove +4 more
wiley +1 more source