Results 1 to 10 of about 62,842 (325)

Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis. [PDF]

open access: yesPLoS ONE, 2012
Barbiturates potentiate GABA actions at the GABA(A) receptor and act as central nervous system depressants that can induce effects ranging from sedation to general anesthesia.
Simon Oakley   +7 more
doaj   +8 more sources

Systematic review and meta-analysis of propofol versus barbiturates for controlling refractory status epilepticus

open access: yesBMC Neurology, 2019
Background Several studies have compared the efficacy and safety of propofol and barbiturates in the treatment of refractory status epilepticus (RSE). This study aims to quantitatively assess the advantages and disadvantages of propofol and barbiturates ...
Qing Zhang, Yu Lu
exaly   +4 more sources

Barbiturates for acute traumatic brain injury

open access: yesThe Cochrane Library, 2012
BACKGROUND Raised intracranial pressure (ICP) is an important complication of severe brain injury, and is associated with a high mortality rate. Barbiturates are believed to reduce intracranial pressure by suppressing cerebral metabolism, thus reducing ...
Ian Roberts
exaly   +3 more sources

How theories evolved concerning the mechanism of action of barbiturates

open access: yesEpilepsia, 2012
The barbiturate phenobarbital has been in use in the treatment of epilepsy for 100 years. It has long been recognized that barbiturates act by prolonging and potentiating the action of γ‐aminobutyric acid (GABA) on GABAA receptors and at higher ...
Wolfgang Löscher   +2 more
exaly   +2 more sources

Barbiturates Use and Its Effects in Patients with Severe Traumatic Brain Injury in Five European Countries

open access: yesJournal of Neurotrauma, 2013
The guidelines for management of traumatic brain injury (TBI) recommend that high-dose barbiturate therapy may be considered to lower intracranial pressure (ICP) that is refractory to other therapeutic options. Lower doses of barbiturates may be used for
Marek Majdan   +2 more
exaly   +2 more sources

The thermodynamics of general and local anesthesia [PDF]

open access: yesBiophys. J. 2014, 106: 2143-2156, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare   +2 more
arxiv   +4 more sources

Radical–Radical Cyclization Cascades of Barbiturates Triggered by Electron-Transfer Reduction of Amide-Type Carbonyls

open access: yesJournal of the American Chemical Society, 2016
Radical-radical cyclization cascades, triggered by single-electron transfer to amide-type carbonyls by SmI2-H2O, convert simple achiral barbiturates in one step to hemiaminal- or enamine-containing tricyclic scaffolds containing up to five contiguous ...
Huan-ming Huang, David J Procter
exaly   +2 more sources

Low Risk of Development of Substance Dependence for Barbiturates and Clobazam Prescribed as Antiepileptic Drugs: Results from a Questionnaire Study

open access: yesCNS Neuroscience and Therapeutics, 2009
There is no systematical research about the topic of dependence on antiepileptic drugs (AED) for patients with epilepsy, despite the fact that barbiturates and benzodiazepines comprise a potential risk of dependence.
C. Uhlmann, W. Fröscher
exaly   +2 more sources

Association Between Spinal Manipulation, Butalbital Prescription, and Medication Overuse Headache in Adults With Tension-Type Headache: Retrospective Cohort Study. [PDF]

open access: yesHealth Sci Rep
Background and Aims Butalbital is an acute headache medication commonly prescribed for tension‐type headache (TTH), although discouraged by guidelines due to a risk of medication overuse headache (MOH).
Trager RJ   +3 more
europepmc   +2 more sources

Barbiturates Induce Mitochondrial Depolarization and Potentiate Excitotoxic Neuronal Death

open access: yesJournal of Neuroscience, 2002
Barbiturates are widely used as anesthetics, anticonvulsants, and neuroprotective agents. However, barbiturates may also inhibit mitochondrial respiration, and mitochondrial inhibitors are known to potentiate NMDA receptor-mediated neurotoxicity. Here we
Christopher M Anderson
exaly   +2 more sources

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