Results 1 to 10 of about 27,066 (218)

Topiramate and other kainate receptor antagonists for depression: A systematic review of randomized controlled trials

open access: yesNeuropsychopharmacology Reports, 2022
Background Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the ...
Ahmad Shamabadi
doaj   +1 more source

Early use of barbiturates is associated with increased mortality in traumatic brain injury patients from a propensity score-based analysis of a prospective cohort.

open access: yesPLoS ONE, 2022
Barbiturates are proposed as a second/third line treatment for intracranial hypertension in traumatic brain injury (TBI) patients, but the literature remains uncertain regarding their benefit/risk balance.
Maxime Léger   +11 more
doaj   +1 more source

Comparative analysis of suicidal poisoning autopsied at the Institute of forensic medicine in Belgrade [PDF]

open access: yesPraxis Medica, 2014
Number of poisons which surround the modern man is constantly on the rise and hence therefore the frequency of intoxication. The aim of the study was to determine the type of poison which causes the suicidal poisoning, sex, age, occupation, place of ...
Jakšić Vladimir   +3 more
doaj   +1 more source

New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate

open access: yesMolecules, 2012
A three step synthesis of various thiobarbiturate derivatives 17–24 was established. The first step is mediated by Mn(OAc)3, in order to generate a carbon-carbon bond between a terminal alkene and malonate.
Patrice Vanelle   +2 more
doaj   +1 more source

Barbiturates and pyrazolopyridines for the treatment of postpartum depression—repurposing of two drug classes

open access: yesFrontiers in Pharmacology, 2023
Zulresso (brexanolone) is an aqueous formulation of the neurosteroid, allopregnanolone, and the only FDA-approved medication for the treatment of postpartum depression (PPD).
Alexander B. Horwitz   +2 more
doaj   +1 more source

Sedation-Induced Burst Suppression Predicts Positive Outcome Following Traumatic Brain Injury

open access: yesFrontiers in Neurology, 2021
While electroencephalogram (EEG) burst-suppression is often induced therapeutically using sedatives in the intensive care unit (ICU), there is hitherto no evidence with respect to its association to outcome in moderate-to-severe neurological patients. We
Joel Frohlich   +11 more
doaj   +1 more source

Capacities of Follow-up of the Severity of Acute Barbiturate Intoxications and their Prediction

open access: yesОбщая реаниматология, 2005
Seventy-eight patients with moderate, severe, and fatal (n = 12) acute intoxication with barbiturates, as evidenced by the measurements of their blood concentrations were examined.
I. I. Vorobyeva   +2 more
doaj   +1 more source

Crystal structure of trimethylammonium 5-(2,4-dinitrophenyl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate

open access: yesActa Crystallographica Section E, 2014
The asymmetric unit of the title molecular salt, C3H10N+·C12H9N4O7− [alternative name: trimethylammonium 5-(2,4-dinitrophenyl)-1,3-dimethyl barbiturate], contains one anion and two half-occupancy cations.
Sridevi Gunaseelan   +1 more
doaj   +1 more source

Buthalital and methitural – 5,5-substituted derivatives of 2-thiobarbituric acid forming the same type of hydrogen-bonded chain

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2017
The molecule of buthalital, (I) [systematic name: 5-(2-methylpropyl)-5-(prop-2-en-1-yl)-2-sulfanylidene-1,3-diazinane-4,6-dione], C11H16N2O2S, exhibits a planar pyrimidine ring, whereas the pyrimidine ring of methitural, (II) [systematic name: 5-(1 ...
Thomas Gelbrich, Ulrich J. Griesser
doaj   +1 more source

A Letter About Phenobarbital Poisoning [PDF]

open access: yesInternational Journal of Medical Toxicology and Forensic Medicine, 2020
The ever-increasing sensitivity of humans and living in a world full of stress and anxiety have led to the increased consumption of painkillers and sleeping pills. Barbiturates, which are among the most important sedatives, are regularly used by ordinary
Zahra Ataee , Maryam Sayyari Doughabadi
doaj   +1 more source

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