Results 91 to 100 of about 63,635 (317)

Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: An exploratory descriptive study using a nationwide claims database

open access: yesJournal of Epidemiology, 2017
Background: Little is known about the nationwide epidemiology of the annual rate, causative substance, and clinical course of overdose-related admission.
Yasuyuki Okumura
doaj   +1 more source

Cost‐Effective Nanosensor Solutions for Ultra‐Sensitive Detection of Metronidazole

open access: yesAnalytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Metronidazole (MNZ) is a widely used imidazole antibiotic effective against bacterial and protozoal infections, including giardiasis, trichomoniasis, bacterial vaginosis, and antibiotic‐associated colitis. However, prolonged and excessive use of MNZ can lead to serious side effects, such as peripheral neuropathies, toxicity, and optic ...
Ahmad Mobed   +6 more
wiley   +1 more source

Synthesis, X-Ray Crystal Structures, Biological Evaluation, and Molecular Docking Studies of a Series of Barbiturate Derivatives

open access: yesJournal of Chemistry, 2016
A series of barbiturates derivatives synthesized and screened for different set of bioassays are described. The molecular structures of compounds 5a, 5d, and 5f were solved by single-crystal X-ray diffraction techniques. The results of bioassay show that
Assem Barakat   +9 more
doaj   +1 more source

Enamine Barbiturates and Thiobarbiturates as a New Class of Bacterial Urease Inhibitors

open access: yesApplied Sciences, 2020
Urease is a therapeutic target associated with several important diseases and health problems. Based on our previous work on the inhibition of glucosidase and other enzymes and exploiting the privileged structure assigned to the (thio)barbiturate ...
M. Ali   +9 more
doaj   +1 more source

Presumptive Tests for Xylazine—A Computer Vision Approach

open access: yesAnalytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT Abuse of xylazine is an immediate global public health concern. We report the distinct and measurable colour changes when xylazine is exposed to the Mandelin, Marquis and Mecke presumptive test reagents. The colour changes observed with xylazine are distinct from those of drugs that give colour changes from the same presumptive tests.
Hui Yun Chang   +6 more
wiley   +1 more source

A rapid ultraviolet spectrophotometric method for the detection, estimation and identification of barbiturates in biological material.

open access: yesBiochemical Journal, 1956
spectrophotometric methods for the determination of 5:5'-disubstituted barbiturates ...
P. Broughton
semanticscholar   +1 more source

Nationwide trends in diagnosed sedative, hypnotic or anxiolytic use disorders in adolescents and young adults enrolled in Medicaid: 2001–2019

open access: yesAddiction, Volume 120, Issue 5, Page 951-961, May 2025.
Abstract Background and Aim Sedative, hypnotic or anxiolytic use disorders (SHA‐UD) are defined by significant impairment or distress caused by recurrent sedative, hypnotic or anxiolytic use. This study aimed to measure trends in the prevalence of SHA‐UD diagnoses in adolescent and young adult US Medicaid enrollees from 2001 to 2019.
Greta Bushnell   +6 more
wiley   +1 more source

High dose barbiturates in non‐traumatic brain swelling: ICP reduction and effect on outcome.

open access: yesStroke, 1982
High dose barbiturates were used to treat intracranial hypertension in 15 patients with nontraumatic brain lesions; (3 hypertensive hemorrhage, 4 subarachnoid hemorrhage, 5 infarction, 2 global anoxia-ischemia and 2 encephalitis).
J. Woodcock, A. Ropper, S. K. Kennedy
semanticscholar   +1 more source

Improving Identification of At‐Risk Behaviors in Adolescents With Rheumatic Disease

open access: yesArthritis Care &Research, Volume 77, Issue 4, Page 522-527, April 2025.
Objective Many adolescent patients view their rheumatologist as their primary physician, and therefore it is important to screen youth for sexual activity and substance use as recommended by the American Academy of Pediatrics. We implemented an electronic social history questionnaire (SHQ) and alert system to identify at‐risk behaviors in adolescents ...
Kristina Ciaglia   +3 more
wiley   +1 more source

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