Results 11 to 20 of about 63,635 (317)
Neuropsychopharmacology Reports, 2022 Background Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the ...
Ahmad Shamabadi
doaj +2 more sources
Journal of Medicinal Chemistry, 2021 We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides.
M. Paulsen +12 more
semanticscholar +1 more source
PLoS ONE, 2022 Barbiturates are proposed as a second/third line treatment for intracranial hypertension in traumatic brain injury (TBI) patients, but the literature remains uncertain regarding their benefit/risk balance.
Maxime Léger +11 more
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Epilepsia Open, EarlyView., 2023 Abstract Growing concerns over rigor and reproducibility of preclinical studies, including consistency across laboratories and translation to clinical populations, have triggered efforts to harmonize methodologies. This includes the first set of preclinical common data elements (CDEs) for epilepsy research studies, as well as Case Report Forms (CRFs ...
Lisa Coles +9 more
wiley +1 more source
Comparative analysis of suicidal poisoning autopsied at the Institute of forensic medicine in Belgrade [PDF]
Praxis Medica, 2014 Number of poisons which surround the modern man is constantly on the rise and hence therefore the frequency of intoxication. The aim of the study was to determine the type of poison which causes the suicidal poisoning, sex, age, occupation, place of ...
Jakšić Vladimir +3 more
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Population pharmacokinetic modeling of daridorexant, a novel dual orexin receptor antagonist
CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 74-86, January 2023., 2023 Abstract The analysis aimed at identifying subject‐specific characteristics (covariates) influencing exposure to daridorexant and quantification of covariate effects to determine clinical relevance. Data from 13 phase I, two phase II, and two phase III studies were pooled to develop a population pharmacokinetic model describing daridorexant ...
Andreas Krause +4 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 1, Page 7-14, January 2023., 2023 Highlights Red blood cell (RBC) lifespan variation, is the main cause of variation in glycosylated hemoglobin (HbA1c), independent of blood glucose levels. This study highlighted the important impact of RBC lifespan on HbA1c test value in T2DM with HbA1c test value <7%. We discovered that the HbA1c test value in type 2 diabetes (T2DM) patients with RBC
Junmei Wang +6 more
wiley +1 more source
Sedation-Induced Burst Suppression Predicts Positive Outcome Following Traumatic Brain Injury
Frontiers in Neurology, 2021 While electroencephalogram (EEG) burst-suppression is often induced therapeutically using sedatives in the intensive care unit (ICU), there is hitherto no evidence with respect to its association to outcome in moderate-to-severe neurological patients. We
Joel Frohlich +11 more
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Medicines legislation and regulation in the United Kingdom 1500‐2020
British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 80-92, January 2023., 2023 The initial purposes of regulation of medicines in England, and latterly in the United Kingdom, were principally to raise government revenue, to discourage murder by poisoning and to regulate the activities of pharmacists. It was only much later that regulators sought to ensure that medicines were of good quality, reasonably safe, and at least somewhat
Robin E. Ferner, Jeffrey K. Aronson
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AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source