Results 11 to 20 of about 27,066 (218)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution

Arquivos de Neuro-Psiquiatria, 1986
Barbiturates are considered first line antiepileptic drugs in third world countries due to traditional and economic reasons. This prospective uncontrolled study of 52 patients aged 15 to 64 years (mean 24) demonstrates that patients who become refractory
Ana Maria Gorz, Carlos E. S. Silvado, Paulo Rogério M. Bittencourt   +2 more
doaj   +1 more source

Systematic review and meta-analysis of propofol versus barbiturates for controlling refractory status epilepticus

BMC Neurology, 2019
Background Several studies have compared the efficacy and safety of propofol and barbiturates in the treatment of refractory status epilepticus (RSE). This study aims to quantitatively assess the advantages and disadvantages of propofol and barbiturates ...
Qing Zhang, Yun Yu, Yu Lu, Hongli Yue
doaj   +1 more source

The use of barbiturate-induced coma during cerebrovascular neurosurgery procedures: A review of the literature

Brain Circulation, 2015
Barbiturates are indicated for use during vascular neurosurgery procedures such as carotid surgery, arteriovenous malformation (AVM) surgery, cerebral aneurysm surgery, extracranial-intracranial bypass, and following significant bleeding due to AVMs or ...
Nathaniel R Ellens, Bryan E Figueroa, Justin C Clark   +2 more
doaj   +1 more source

Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis. [PDF]

PLoS ONE, 2012
Barbiturates potentiate GABA actions at the GABA(A) receptor and act as central nervous system depressants that can induce effects ranging from sedation to general anesthesia.
Simon Oakley, L Sangeetha Vedula, Weiming Bu, Qing Cheng Meng, Jin Xi, Renyu Liu, Roderic G Eckenhoff, Patrick J Loll   +7 more
doaj   +1 more source

Antibacterial Barbituric Acid Analogues Inspired from Natural 3-Acyltetramic Acids; Synthesis, Tautomerism and Structure and Physicochemical Property-Antibacterial Activity Relationships

Molecules, 2015
The synthesis, tautomerism and antibacterial activity of novel barbiturates is reported. In particular, 3-acyl and 3-carboxamidobarbiturates exhibited antibacterial activity, against susceptible and some resistant Gram-positive strains of particular ...
Yong-Chul Jeong, Mark G. Moloney
doaj   +1 more source

Hyperalgesic effect induced by barbiturates, midazolam and ethanol: pharmacological evidence for GABA-A receptor involvement

Brazilian Journal of Medical and Biological Research, 1997
The involvement of GABA-A receptors in the control of nociception was studied using the tail-flick test in rats. Non-hypnotic doses of the barbiturates phenobarbital (5-50 mg/kg), pentobarbital (17-33 mg/kg), and thiopental (7.5-30 mg/kg), of the ...
M.A.K.F. Tatsuo, C.M. Yokoro, J.V. Salgado, S.M.S. Pesquero, M.A.P. Santana, J.N. Francischi   +5 more
doaj   +1 more source

Rectal Thiopental versus Intramuscular Ketamine in Pediatric Procedural Sedation and Analgesia; a Randomized Clinical Trial

Archives of Academic Emergency Medicine, 2018
Introduction: Physicians frequently deal with procedures which require sedation of pediatric patients. Laceration repair is one of them. No study has been performed regarding the comparison between induction of sedation with sodium thiopental and ...
Reza Azizkhani, Mehrdad Esmailian, Azadeh shojaei, Keihan Golshani   +3 more
doaj   +1 more source

The Hydrogen Bonded Structures of Two 5-Bromobarbituric Acids and Analysis of Unequal C5–X and C5–X′ Bond Lengths (X = X′ = F, Cl, Br or Me) in 5,5-Disubstituted Barbituric Acids

Crystals, 2016
The crystal structure of the methanol hemisolvate of 5,5-dibromobarbituric acid (1MH) displays an H-bonded layer structure which is based on N–H∙∙∙O=C, N–H∙∙∙O(MeOH) and (MeOH)O–H∙∙∙O interactions.
Thomas Gelbrich, Doris E. Braun, Stefan Oberparleiter, Herwig Schottenberger, Ulrich J. Griesser   +4 more
doaj   +1 more source

Determination of Barbiturates in Biological Specimens by Flat Membrane-Based Liquid-Phase Microextraction and Liquid Chromatography-Mass Spectrometry

Molecules, 2019
The wide abuse of barbiturates has aroused extensive public concern. Therefore, the determination of such drugs is becoming essential in therapeutic drug monitoring and forensic science.
Ruiqin Zhu, Ying Dong, Xiangyang Cai, Chuixiu Huang   +3 more
doaj   +1 more source