Results 21 to 30 of about 19,466 (148)
The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
arxiv +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Acta Crystallographica Section E, 2014 The asymmetric unit of the title molecular salt, C3H10N+·C12H9N4O7− [alternative name: trimethylammonium 5-(2,4-dinitrophenyl)-1,3-dimethyl barbiturate], contains one anion and two half-occupancy cations.
Sridevi Gunaseelan +1 more
doaj +1 more source
Capacities of Follow-up of the Severity of Acute Barbiturate Intoxications and their Prediction
Общая реаниматология, 2005 Seventy-eight patients with moderate, severe, and fatal (n = 12) acute intoxication with barbiturates, as evidenced by the measurements of their blood concentrations were examined.
I. I. Vorobyeva +2 more
doaj +1 more source
Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution
Arquivos de Neuro-Psiquiatria, 1986 Barbiturates are considered first line antiepileptic drugs in third world countries due to traditional and economic reasons. This prospective uncontrolled study of 52 patients aged 15 to 64 years (mean 24) demonstrates that patients who become refractory
Ana Maria Gorz +2 more
doaj +1 more source
A Letter About Phenobarbital Poisoning [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 The ever-increasing sensitivity of humans and living in a world full of stress and anxiety have led to the increased consumption of painkillers and sleeping pills. Barbiturates, which are among the most important sedatives, are regularly used by ordinary
Zahra Ataee , Maryam Sayyari Doughabadi
doaj +1 more source
Molecules, 2015 The synthesis, tautomerism and antibacterial activity of novel barbiturates is reported. In particular, 3-acyl and 3-carboxamidobarbiturates exhibited antibacterial activity, against susceptible and some resistant Gram-positive strains of particular ...
Yong-Chul Jeong, Mark G. Moloney
doaj +1 more source
Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis. [PDF]
PLoS ONE, 2012 Barbiturates potentiate GABA actions at the GABA(A) receptor and act as central nervous system depressants that can induce effects ranging from sedation to general anesthesia.
Simon Oakley +7 more
doaj +1 more source
Crystals, 2016 The crystal structure of the methanol hemisolvate of 5,5-dibromobarbituric acid (1MH) displays an H-bonded layer structure which is based on N–H∙∙∙O=C, N–H∙∙∙O(MeOH) and (MeOH)O–H∙∙∙O interactions.
Thomas Gelbrich +4 more
doaj +1 more source
Molecules, 2019 The wide abuse of barbiturates has aroused extensive public concern. Therefore, the determination of such drugs is becoming essential in therapeutic drug monitoring and forensic science.
Ruiqin Zhu +3 more
doaj +1 more source