Results 31 to 40 of about 20,407 (174)

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod

Developmental Dynamics, EarlyView.
Abstract Background Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth. Precocial species, which are ambulatory at birth, develop advanced skeletal maturity in utero and experience postnatal development under mechanical loading.
Christopher J. Panebianco, Maha Essaidi, Elijah Barnes, Ashley Williams, Karin Vancíková, Margot C. Labberté, Pieter Brama, Niamh C. Nowlan, Joel D. Boerckel   +8 more
wiley   +1 more source

Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy. [PDF]

PLoS ONE, 2012
GABAergic signaling is essential for proper respiratory function. Potentiation of this signaling with allosteric modulators such as anesthetics, barbiturates, and neurosteroids can lead to respiratory arrest.
Keith B Hengen, Nathan R Nelson, Kyle M Stang, Stephen M Johnson, Stephanie M Crader, Jyoti J Watters, Gordon S Mitchell, Mary Behan   +7 more
doaj   +1 more source

Potentiometric measurement of barbituric acid by integration of supramolecular receptors into ChemFETs

Sensing and Bio-Sensing Research, 2021
Potentiometric sensing devices were prepared based on ion-selective membranes (ISM) containing Hamilton-type receptors incorporated into polymer membranes.
Grace M. Kuhl, Daniel T. Seidenkranz, Michael D. Pluth, Darren W. Johnson, Sean A. Fontenot   +4 more
doaj   +1 more source

”Not always the magic bullet”—Insufficient seizure control by ketogenic dietary therapies in Glut1 Deficiency Syndrome

Epilepsia Open, EarlyView.
Abstract Objective Ketogenic dietary therapies (KDTs) are the treatment of choice for Glut1 Deficiency Syndrome (Glut1DS), providing dietary ketones as an alternative fuel to the brain and effectively controlling seizures. Recent evidence indicates insufficient seizure control in Glut1DS patients despite adequate KDT and ketosis.
Joerg Klepper, Eva Runkel, Lucia Kiesel
wiley   +1 more source

Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System

ChemistryOpen, EarlyView.
Abietic acid (AA) reveals potent sedative potential by expressing fast sleeping onset and increased sleeping duration compare to the control group in thiopental sodium induced sleeping mice. The compound also exhibited notable binding affinity (–7.9 kcal/mol) toward GABAA receptors.
Meher Afroz, Rubel Hasan, Mst Muslima Khatun, Mokammel Hossain Tito, Md Shadin, Ranjit Chakma, Mohammed Asiri, Faisal H. Altemani, Abdullah H. Altemani, Md Shimul Bhuia, Muhammad Torequl Islam   +10 more
wiley   +1 more source

Improving drug identification in overdose death surveillance by using clinical natural language processing models

Journal of Forensic Sciences, EarlyView.
Abstract The rising rate of drug‐related deaths in the United States, largely driven by fentanyl, requires timely and accurate surveillance. However, critical overdose data are often buried in free‐text coroner reports, leading to delays and information loss when coded into ICD (International Classification of Disease)‐10 classifications.
Arthur J. Funnell, Panayiotis Petousis, Fabrice Harel‐Canada, Ruby Romero, Alex A. T. Bui, Adam Koncsol, Hritika Chaturvedi, Chelsea Shover, David Goodman‐Meza   +8 more
wiley   +1 more source

Rapid visualization of fingerprints on various surfaces using ZnO superstructures prepared via simple combustion route

Journal of Science: Advanced Materials and Devices, 2018
A simple solution combustion route has been used to prepare ZnO nanopowders (NPs) using different barbiturates (Barbituric acid, 1, 3-dimethyl barbiturates and 2-thiobarbiturates) as fuels.
N.H. Deepthi, R.B. Basavaraj, S.C. Sharma, J. Revathi, Ramani, S. Sreenivasa, H. Nagabhushana   +6 more
doaj   +1 more source

Assessment of Controlled Substance Distribution to U.S. Veterinary Teaching Institutions From 2006 to 2019

Frontiers in Veterinary Science, 2020
Objective: To evaluate the changing pattern of distribution of Schedule II and III opioids, barbiturates, and stimulants to veterinary educational institutions in the United States.Design: Longitudinal study.Sample: Veterinary teaching institutions that ...
Brian J. Piper, Brian J. Piper, Kenneth L. McCall, Lori R. Kogan, Peter Hellyer   +4 more
doaj   +1 more source

Brain pathology caused in the neonatal macaque by short and prolonged exposures to anticonvulsant drugs

Neurobiology of Disease, 2021
Barbiturates and benzodiazepines are potent GABAA receptor agonists and strong anticonvulsants. In the developing brain they can cause neuronal and oligodendroglia apoptosis, impair synaptogenesis, inhibit neurogenesis and trigger long-term ...
Kevin K. Noguchi, Nicole A. Fuhler, Sophie H. Wang, Saverio Capuano, III, Kevin R. Brunner, Shreya Larson, Kristin Crosno, Heather A. Simmons, Andres F. Mejia, Lauren D. Martin, Gregory A. Dissen, Ansgar Brambrink, Chrysanthy Ikonomidou   +12 more
doaj   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source