Results 31 to 40 of about 63,635 (317)

A Letter About Phenobarbital Poisoning [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2020
The ever-increasing sensitivity of humans and living in a world full of stress and anxiety have led to the increased consumption of painkillers and sleeping pills. Barbiturates, which are among the most important sedatives, are regularly used by ordinary
Zahra Ataee , Maryam Sayyari Doughabadi
doaj   +1 more source

New patents on topical anesthetics. [PDF]

, 2014
Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano, CANTISANI, CARMEN, D'ANDREA, Vito, Frascani, F, MACALUSO, LAURA, paolino, giovanni, RICHETTA, Antonio Giovanni   +6 more
core   +1 more source

Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution

Arquivos de Neuro-Psiquiatria, 1986
Barbiturates are considered first line antiepileptic drugs in third world countries due to traditional and economic reasons. This prospective uncontrolled study of 52 patients aged 15 to 64 years (mean 24) demonstrates that patients who become refractory
Ana Maria Gorz, Carlos E. S. Silvado, Paulo Rogério M. Bittencourt   +2 more
doaj   +1 more source

Barbiturate and picrotoxin-sensitive chloride efflux in rat cerebral cortical synaptoneurosomes [PDF]

, 1984
The effects of various barbiturates and picrotoxin in modifying the efflux of chloride (36Cl−) was studied in a novel subcellular preparation from rat cerebral cortex, the ‘synaptoneurosome’.
Hollingsworth, Elizabeth B., Paul, Steven M., Schwartz, Rochelle D., Skolnick, Phil   +3 more
core   +1 more source

Antibacterial Barbituric Acid Analogues Inspired from Natural 3-Acyltetramic Acids; Synthesis, Tautomerism and Structure and Physicochemical Property-Antibacterial Activity Relationships

Molecules, 2015
The synthesis, tautomerism and antibacterial activity of novel barbiturates is reported. In particular, 3-acyl and 3-carboxamidobarbiturates exhibited antibacterial activity, against susceptible and some resistant Gram-positive strains of particular ...
Yong-Chul Jeong, Mark G. Moloney
doaj   +1 more source

The Hydrogen Bonded Structures of Two 5-Bromobarbituric Acids and Analysis of Unequal C5–X and C5–X′ Bond Lengths (X = X′ = F, Cl, Br or Me) in 5,5-Disubstituted Barbituric Acids

Crystals, 2016
The crystal structure of the methanol hemisolvate of 5,5-dibromobarbituric acid (1MH) displays an H-bonded layer structure which is based on N–H∙∙∙O=C, N–H∙∙∙O(MeOH) and (MeOH)O–H∙∙∙O interactions.
Thomas Gelbrich, Doris E. Braun, Stefan Oberparleiter, Herwig Schottenberger, Ulrich J. Griesser   +4 more
doaj   +1 more source

Determination of Barbiturates in Biological Specimens by Flat Membrane-Based Liquid-Phase Microextraction and Liquid Chromatography-Mass Spectrometry

Molecules, 2019
The wide abuse of barbiturates has aroused extensive public concern. Therefore, the determination of such drugs is becoming essential in therapeutic drug monitoring and forensic science.
Ruiqin Zhu, Ying Dong, Xiangyang Cai, Chuixiu Huang   +3 more
doaj   +1 more source

Doctor or drug dealer? International legal provisions for the legitimate handling of drugs of abuse [PDF]

, 2020
© The Author(s) 2020. The final, definitive version of this paper has been published in: Gallagher, C. T., Atik, S. K., Isse, L., & Mann, S. K. (2020). Doctor or drug dealer?
Atik, Sanaa, Gallagher, Cathal, Isse, Libin, Mann, Sanpreet   +3 more
core   +1 more source

Hyperalgesic effect induced by barbiturates, midazolam and ethanol: pharmacological evidence for GABA-A receptor involvement

Brazilian Journal of Medical and Biological Research, 1997
The involvement of GABA-A receptors in the control of nociception was studied using the tail-flick test in rats. Non-hypnotic doses of the barbiturates phenobarbital (5-50 mg/kg), pentobarbital (17-33 mg/kg), and thiopental (7.5-30 mg/kg), of the ...
M.A.K.F. Tatsuo, C.M. Yokoro, J.V. Salgado, S.M.S. Pesquero, M.A.P. Santana, J.N. Francischi   +5 more
doaj   +1 more source

Rectal Thiopental versus Intramuscular Ketamine in Pediatric Procedural Sedation and Analgesia; a Randomized Clinical Trial

Archives of Academic Emergency Medicine, 2018
Introduction: Physicians frequently deal with procedures which require sedation of pediatric patients. Laceration repair is one of them. No study has been performed regarding the comparison between induction of sedation with sodium thiopental and ...
Reza Azizkhani, Mehrdad Esmailian, Azadeh shojaei, Keihan Golshani   +3 more
doaj   +1 more source