Results 61 to 70 of about 27,317 (231)

Longan flower water extract promotes sleep in mice via the serotonin–melatonin axis

Journal of the Science of Food and Agriculture, Volume 106, Issue 3, Page 1852-1860, February 2026.
Abstract BACKGROUND Longan (Dimocarpus longan) flower is an underutilized botanical byproduct rich in polyphenols with reported neuroprotective actions, yet its role in sleep regulation remains unclear. This study aimed to evaluate the sleep‐promoting effects of longan flower water extract (LFWE) and its underlying neurochemical mechanisms in vivo ...
Tzu‐Huan Hung, Chiu‐Ping Cheng, Wei‐Chung Chiou, Tzu‐Lan Hsia, Hui‐Kang Liu, Hsu‐Feng Lu, Yu‐Heng Lai, Shang‐Ting Tsai, Chiung‐Ju Chen, Cheng Huang   +9 more
wiley   +1 more source

Evolution of Pharmacologic Induction of Burst Suppression in Adult TBI: Barbiturate Coma Versus Modern Sedatives

Clinical and Translational Neuroscience
Background: Severe traumatic brain injury (TBI) often leads to elevated intracranial pressure (ICP) that requires aggressive management. Inducing burst suppression with deep sedation is an established therapy for refractory intracranial hypertension ...
Đula Đilvesi, Teodora Tubić, Sanja Maričić Prijić, Jagoš Golubović   +3 more
doaj   +1 more source

First‐in‐Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP1617, a Cathepsin‐S Inhibitor, in Healthy Adult Subjects

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT ASP1617 is a novel, highly selective inhibitor of cathepsin‐S, an important protease for antigen peptide loading onto major histocompatibility complex class II molecules. Preclinically, ASP1617 prevented progression of lupus‐like glomerulonephritis in an NZB/W F1 mouse model of systemic lupus erythematosus.
Tomoki Kojima, Wei Chen, Ronald Smulders, Stephen Stanhope, Donna Kowalski, Nakyo Heo, Selina Moy, Amanda Goldston, David Han, Tong Zhu   +9 more
wiley   +1 more source

Recent Advances in Homogeneous Catalysis with Platinum Group Pincer Complexes: Hydrogen‐Mediated Transformations and Cross‐Coupling Reactions

The Chemical Record, Volume 26, Issue 1, January 10, 2026.
Platinum group pincer complexes are highly efficient catalysts. Additionally, their high activity enables challenging transformations with low catalyst loading. Herein, we summarize the most relevant advances of catalysis involving platinum group pincer complexes. The use of pincer complexes based on platinum group metals is undoubtedly one of the most
Juan S. Serrano‐García, Andrés Amaya‐Flórez, Jordi R.‐Galindo, Adrián Ruíz‐Martínez, David Morales‐Morales   +4 more
wiley   +1 more source

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 172-185, January 2026.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside, Ellie He, Manjunath S. Shet, Mingyan Zhou, Maha Ahmad, Stephen C. Harris   +5 more
wiley   +1 more source

Effects of Indomethacin on Cerebral Blood Flow and Oxygen Consumption in Barbiturate-Anesthetized Normocapnic and Hypercapnic Rats [PDF]

, 1981
Nils Dahlgren, Bo K. Siesjö
openalex   +1 more source

L‐Quebrachitol Enhances Sedative Effect of Diazepam Through GABAergic Pathway: Animal and Computational Studies

Brain and Behavior, Volume 16, Issue 1, January 2026.
L‐quebrachitol (LQL) significantly enhanced the sedative effects of diazepam in thiopental sodium‐induced chicks by reducing sleep latency and prolonging duration. Molecular docking revealed LQL's interaction with GABAA receptor (α1 and β2 subunits), supporting a GABAergic mechanism and highlighting its potential as a safe, natural sedative agent ...
Asifa Asrafi, Mohammad Aslam, Md. Sakib Al Hasan, Mohammed Burhan Uddin, Emon Mia, Mohammad Y. Alshahrani, Sumaya Akter Bithi, Mst. Sumaia Akter, Md. Arif Hossain, Md. Torequl Islam   +9 more
wiley   +1 more source

The sensitivity of the brain to barbiturate during chronic administration and withdrawal of barbitone sodium in the rat [PDF]

, 1970
Ian H. Stevenson, M J Turnbull
openalex   +1 more source

Association Between Dietary Fatty Acid Intake With Cardiovascular Disease Risk and Serum Lipid Levels

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
The findings suggest a protective role of MUFA intake against CVDs risk. ABSTRACT Background Despite early interest in the effects of dietary fats on cardiovascular diseases (CVDs), substantial controversy remains regarding the evidence linking different types of fatty acids to CVDs.
Naeemeh Hassanpour Ardekanizadeh, Khadijeh Abbasi Mobarakeh, Sheyda Nami, Maryam Shojaei, Seyed Fazel Nasimi, Saba Moradi, Faezeh Tejareh, Yeganeh Shekari, Parsa Bahmani, Maryam Gholamalizadeh, Marjan Ajami, Akram Kooshki, Saeid Doaei   +12 more
wiley   +1 more source

Exploratory Pain Profiling With Quantitative Sensory Testing (QST) in Episodic and Chronic Migraine

European Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Migraine pain profiling studies vary by sensory modalities, methods, anatomical sites and characteristics. This exploratory study aimed to identify pain profiling parameters using quantitative sensory testing (QST) for episodic migraine (EM) and chronic migraine (CM) and investigate potential differences, given conflicting results ...
Rein F. van Welie, Floor C. van Welie, Jennifer P. Trouerbach‐Kraan, Albert Dahan, Monique van Velzen, Gisela M. Terwindt   +5 more
wiley   +1 more source