GLUT1-Deficiency: Barbiturates Potentiate Haploinsufficiency in Vitro
Pediatric Research, 1999 Barbiturates are known to inhibit glucose transport mediated by the facilitative sugar transporter GLUT1. We have studied such inhibition in children with GLUT1-deficiency.
J. Klepper +4 more
semanticscholar +1 more source
Towards interlocked structures based on H-bonded barbiturate complexes [PDF]
, 2010 Despite the privileged position of Hamilton’s barbiturate binding system in supramolecular chemistry, this motif has never been used in generating interlocked structures, such as rotaxanes or catenanes.
Rocher, Mathias
core
Heroin Adulterated with the Novel Synthetic Cannabinoid, 5F-MDMB-PINACA: A Case Series [PDF]
, 2020 Introduction: Heroin can be adulterated with various substances that may or may not have pharmacological effects. Here we report a case series of 8 patients who presented to the emergency department after overdose with intravenous heroin preparation ...
Arnold, Ryan +5 more
core
PLoS ONE, 2020 Microglia, the resident immune cells of the brain, are highly ramified and motile and their morphology is strongly linked to their function. Microglia constantly monitor the brain parenchyma and are crucial for maintaining brain homeostasis and fine ...
Ines Hristovska +7 more
doaj +1 more source
Characteristics of Belgian 'life-ending acts without explicit patient request' : a large-scale death certificate survey revisited [PDF]
, 2014 BACKGROUND: “Life-ending acts without explicit patient request,” as identified in robust international studies, are central in current debates on physician-assisted dying.
Bernheim, Jan L +3 more
core +2 more sources
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2’-bipyridine and 2,2’-dipyridylamine : synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity [PDF]
, 2015 Peer ...
Buyukgungor, Orhan +5 more
core +1 more source
Best practices for blood collection and anaesthesia in mice: Selection, application and reporting
British Journal of Pharmacology, EarlyView.Abstract Blood collection in mice is a common procedure in biomedical research. The choice of blood collection method and the need for analgesia and/or anaesthesia depend on multiple factors, including the experimental setup, animal welfare considerations and the intended downstream analyses.
Zhixin Li +10 more
wiley +1 more source
Medical Journal of Australia, EarlyView.Abstract Objective To compare the toxicity (relative to population use) and lethality (relative to poisoning events) of medicines involved in poisoning suicides in Australia; to determine the proportions of cases in which the medicines had recently been dispensed to the deceased person.
Jessy Lim +6 more
wiley +1 more source
Journal of Pediatric Critical CareBackground: Pediatric patients require pharmacological management of pain and agitation associated with mechanical ventilation. Pain and agitation may be refractory to opioids and alpha-2 agonists, prompting the use of adjunctive analgesics and sedatives
Kelli Jo Welter +3 more
doaj +1 more source