Results 101 to 110 of about 45,649 (267)

IC‐P‐052: Amyloid Levels in Cerebral Spinal Fluid Influences The Pattern of Cortical and Basal Forebrain Atrophy in Mild Cognitive Impairment [PDF]

open access: bronze, 2016
Ingo Kilimann   +7 more
openalex   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

open access: yesIbrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard   +2 more
wiley   +1 more source

Basal Forebrain Volume and Concurrent Hallucinations and Mild Cognitive Impairment in Parkinson's Disease

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Visual hallucinations (VH) and mild cognitive impairment (MCI) often co‐occur in Parkinson's Disease (PD). Each symptom in isolation is associated with cholinergic basal forebrain (BF) atrophy. However, it is unclear whether BF integrity relates to one symptom preferentially or to their co‐occurrence, and whether this relationship ...
Sabrina M. Adamo   +6 more
wiley   +1 more source

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

open access: yesMovement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger   +1 more
wiley   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang   +12 more
wiley   +1 more source

Simultaneous Detection of GABA and Glycine Using MEGA‐PRESS With TE Optimization at 3T

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To achieve the simultaneous acquisition of gamma‐aminobutyric acid (GABA) and glycine (Gly) using a MEGA‐PRESS sequence with an optimized TE at 3T. Methods MEGA‐PRESS simulations were performed at TEs 60‐88 ms to determine the optimal TE for Gly detection with minimal myo‐Inositol (mI) overlap and maximal GABA detection sensitivity ...
Justin R. Singer, Kimberly L. Chan
wiley   +1 more source

Reduction in Brain Parenchymal Volume Correlates with Depression and Cognitive Decline in HIV-Positive Males

open access: yesMedicina
Background and Objectives: Human immunodeficiency virus (HIV) has a profound impact on the central nervous system (CNS), contributing to cognitive impairment and depressive symptoms even in individuals receiving combination antiretroviral therapy (cART).
Radmila Perić   +6 more
doaj   +1 more source

Quantitative Comparison of Multi‐Echo Spin Echo and Multi‐Echo Gradient Echo Myelin Water Imaging in a Panel of Mbp Enhancer‐Edited Mouse Lines

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate the correspondence between myelin water fraction (MWF) estimates derived from multi‐echo spin echo (MESE) and multi‐echo gradient echo (MGRE) imaging in fixed mouse brain tissue, using a panel of myelin basic protein (Mbp) enhancer‐edited mouse lines exhibiting graded hypomyelination.
Vladimir Grouza   +11 more
wiley   +1 more source

Which Patients With Dysfunctional Voiding Respond Well to Sacral Neuromodulation? ICI‐RS 2025

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Aims Dysfunctional voiding (DV) is characterised by fluctuating or intermittent urinary flow during voiding in neurologically normal individuals. Given the different definitions used and heterogeneous pathophysiologies, outcomes following sacral neuromodulation/sacral nerve stimulation (SNM/SNS) are variably reported.
Jalesh N. Panicker   +8 more
wiley   +1 more source

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