Results 171 to 180 of about 45,649 (267)

Disruption of the l‐DOPA Receptor Gpr143/OA1‐Gene in Mice Creates a Unique Mixed Psychosis‐Like Phenotype

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
We analyzed the behavior of GPR143 gene‐deficient mice. GPR143‐KO mice displayed a mixed psychiatric phenotype. GPR143 may play a role in mesolimbic and mesocortical functions underlying sensory gating, reward, social hierarchy, cognition, and emotional regulation. ABSTRACT GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a
Yoshio Goshima, Haruko Nakamura, Motokazu Koga, Junka Koyama, Yayoi Kimura, Maya N. Vasishth, Evan Y. Snyder, Masashi Asai, Kenta Sakai, Daiki Masukawa   +9 more
wiley   +1 more source

Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice [PDF]

, 2018
Chun Yang, Andrei Larin, James T Mckenna, Kenneth A. Jacobson, Stuart Winston, Robert E. Strecker, Anna V. Kalinchuk, Radhika Basheer, Ritchie E. Brown   +8 more
openalex   +1 more source

How Are Sleep, Settle, and Crying Behaviors in 2‐Month‐Olds Related to Concurrent Family Factors and Later Development?

Developmental Science, Volume 29, Issue 2, March 2026.
ABSTRACT Sleep, settle, and crying behaviors represent basic regulatory functions in early infancy, yet little is known about the factors that influence these behaviors and their relationship to later development in the general population. In this study, we assessed a sample of 362 infants, measuring parent‐rated number of wakeups per night, time to ...
Charlotte Viktorsson, Irzam Hardiansyah, Amelia Juslin, Terje Falck‐Ytter   +3 more
wiley   +1 more source

Detection of endogenous acetylcholine release from the rat basal forebrain slices

, 1987
Takeshi Suzuki, Misao Hisada, Tomoko Miyagawa, Akiko Nagoshi, Kazuko Fujimoto, Hisayo Oohata, Koichiro Kawashima   +6 more
openalex   +1 more source

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early‐onset sleep disruption in AD‐like amyloidogenic mice

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep–wake disturbances frequently occur at early stages of Alzheimer's disease (AD) and accelerate disease progression, but the underlying neural mechanisms are not fully understood. METHODS We examined sleep–wake behavior and locus coeruleus (LC) activity in young 5xFAD mice using electrophysiology and pharmacological approaches
Yi‐Ci Zhang, Xue‐Ting Zhang, Peng‐Yue Chen, Zi‐Yue Zhou, Mao‐Qing Huang, Kai‐Wen He   +5 more
wiley   +1 more source

High‐mobility Group Protein 1/ Receptor for Advanced Glycation End Products/ Nuclear Factor‐κB Signalling Pathway Contributes to the Pathogenic Process of Striatal Neuron Impairment in the Rat Model of Parkinson's Disease

Brain and Behavior, Volume 16, Issue 2, February 2026.
In Parkinson's disease, the death of dopamine neurons in the substantia nigra, resulting in a decrease in dopamine levels in the striatum. This leads to striatal damage through the HMGB1/RAGE/NF‐κB signaling pathway, thereby inducing motor and cognitive dysfunction.
Yaofeng Zhu, Zean Du, Liping Sun, Ziyun Huang, Linju Jia, Tao Chen, Xuefeng Zheng, Wanlong Lei   +7 more
wiley   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Evidence for a cholinergic projection to neocortex from neurons in basal forebrain.

, 1979
Michael V. Johnston, Michael McKinney, Joseph T. Coyle   +2 more
openalex   +2 more sources

P2‐397: REDUCED BASAL FOREBRAIN FUNCTIONAL CONNECTIVITY IN WOMEN WITH SUBJECTIVE MEMORY COMPLAINTS COMPARED TO MEN [PDF]

, 2018
Enrica Cavedo, Patrizia A. Chiesa, Marion Houot, Maria Teresa Ferretti, Michel J. Grothe, Stefan Teipel, Simone Lista, Bruno Dubois, Harald Hampel, the INSIGHT-PreAD Study Group for the Alzheimer Precision Medicine Initiative (APMI)   +9 more
openalex   +1 more source

CRISPR‐Cas9‐Generated TXNDC15 c.560delA Homozygous Mouse Model Exhibits Meckel–Gruber Syndrome Phenotype

genesis, Volume 64, Issue 1, February 2026.
ABSTRACT To determine whether TXNDC15 variation causes Meckel–Gruber syndrome (MKS), we assessed the pathogenicity of the frameshift variant c.560delA. A CRISPR–Cas9 generated mouse model carrying the equivalent Txndc15 c.512delA mutation was analyzed at embryonic day 15.5.
Yang Liu, Hui Wang, Liyuan Chen, Xiaoxia Wu, Zhiyong Xu, Qingfa Huang, Hu Zhang, Xiushu Cao, Xinyuan Liang, Xingjian Zhong, Caiqun Luo   +10 more
wiley   +1 more source