Results 251 to 260 of about 515,050 (293)
PRPF8 Mutation-Induced Defects in Human iPSC-Derived RPE Are Rescued by Adenine Base Editing. [PDF]
Invest Ophthalmol Vis SciSun X +10 more
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New England Journal of Medicine, 2021 Extending Life Span in a Mouse Model of Progeria The Hutchinson–Gilford progeria syndrome is an autosomal dominant disease caused by a single point mutation in LMNA, which encodes the lamin A and C...
Jin-Soo, Kim, Maria, Eriksson
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Base editing: advances and therapeutic opportunities [PDF]
Nature Reviews Drug Discovery, 2020 Base editing - the introduction of single-nucleotide variants (SNVs) into DNA or RNA in living cells - is one of the most recent advances in the field of genome editing.
Alexis C Komor +2 more
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Adenine base editor engineering reduces editing of bystander cytosines
Nature Biotechnology, 2021 Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of interest. However, ABEs also induce cytosine deamination at the target site.
You Kyeong Jeong +2 more
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A Review on Advanced CRISPR-Based Genome-Editing Tools: Base Editing and Prime Editing
Molecular Biotechnology, 2022In the field of medicine, it is axiomatic that the need of a precise gene-editing tool is critical to employ therapeutic approaches toward pathogenic mutations, occurring in human genome. Today we know that most of genetic defects are caused by single-base pair substitutions in genomic DNA.
Ali Saber Sichani +4 more
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Base editing goes into hyperdrive
Nature Cell Biology, 2020CRISPR base editors can induce single-base-pair changes in the genome, although they are often inefficient. A study now shows that fusion of the DNA-binding domain of RAD51 to base editors enhances both the efficiency and the targeting range of optimized enzymes. These ‘hyper-editors’ offer effective tools for disease modeling and gene therapy.
Alyna Katti, Lukas E. Dow
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Pattern Recognition, 2003
In this paper, we demonstrate how to edit digital photos based on the understanding of high-level geometric knowledge imposed upon objects in the photos. This is achieved by the correct recovery of the 3-D shape and relationships of the objects, without explicitly performing full 3-D reconstruction.
Kun Huang 0001 +2 more
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In this paper, we demonstrate how to edit digital photos based on the understanding of high-level geometric knowledge imposed upon objects in the photos. This is achieved by the correct recovery of the 3-D shape and relationships of the objects, without explicitly performing full 3-D reconstruction.
Kun Huang 0001 +2 more
openaire +1 more source
Cytosine Base Editing in Bacteria
2023Base editing is a new genome editing technology that enables DNA base mutations without requiring double-stranded DNA backbone cleavage or a donor template. It has been widely used for genome engineering of eukaryotic and prokaryotic microorganisms.
Ye, Liu +4 more
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Base Editing: A New Approach to Genome Editing
, 2019 Genome editing technologies, such as the recently discovered CRISPR/Cas9 system, allow the researcher to site-specifically modify genes of interest in living cells and organisms, and have the potential to yield new therapeutics to cure genetic diseases.
Kim, Yongjoo
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Nature Biotechnology, 2017
Research on base editing leads to new enzymes, genome-wide specificity measurements, and edited plants and animals.
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Research on base editing leads to new enzymes, genome-wide specificity measurements, and edited plants and animals.
openaire +2 more sources