Results 251 to 260 of about 1,037,544 (299)

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Deep learning models simultaneously trained on multiple datasets improve base-editing activity prediction. [PDF]

Nat Commun
Sun Y, Qu K, Corsi GI, Anthon C, Pan X, Xiang X, Jensen LJ, Lin L, Luo Y, Gorodkin J.   +9 more
europepmc   +1 more source

Base editing platform to investigate pathogenic SAMD9 mutations in paediatric myelodysplastic syndromes. [PDF]

Br J Haematol
Canciani G, Lecis M, Frati G, D'Agostino V, Gelosi M, Del Bufalo F, Palumbo G, Palma P, Locatelli F, Ceglie G.   +9 more
europepmc   +1 more source

Base editing both DNA strands in distinct editing windows with small CRISPR-associated effector Cas12f1. [PDF]

iScience
Swartjes T, Bouzetos E, Adiego-Pérez B, Pool VD, Staals RHJ, van der Oost J, Wu WY.   +6 more
europepmc   +1 more source

Development and application of base editing systems in Salvia miltiorrhiza for precise metabolic engineering. [PDF]

Plant Biotechnol J
Yao Q, Ye Y, Liu Q, Tian Y, Xiang L, Li L, Liu H, Zhang Y, Yu M, Zheng H, Huang L.   +10 more
europepmc   +1 more source

Highly efficient gene knockout in tumor-infiltrating lymphocytes by adenine base editing. [PDF]

Mol Ther Oncol
Hafezi M, Genolet R, Hadadi L, Chap BS, Bobisse S, Giordano Attianese GMP, El Jorfi H, Cropp D, Pericou L, Arnaud M, Scholten K, Maurouard T, Laniti DD, Harari A, Gentner B, Irving M, Coukos G.   +16 more
europepmc   +1 more source

BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments

Dinçer C, Fussing B, Garnett MJ, Coelho MA.   +3 more
europepmc   +1 more source

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Base Editing in Progeria

New England Journal of Medicine, 2021
Extending Life Span in a Mouse Model of Progeria The Hutchinson–Gilford progeria syndrome is an autosomal dominant disease caused by a single point mutation in LMNA, which encodes the lamin A and C...
Jin-Soo, Kim, Maria, Eriksson
openaire   +2 more sources

A Review on Advanced CRISPR-Based Genome-Editing Tools: Base Editing and Prime Editing

Molecular Biotechnology, 2022
In the field of medicine, it is axiomatic that the need of a precise gene-editing tool is critical to employ therapeutic approaches toward pathogenic mutations, occurring in human genome. Today we know that most of genetic defects are caused by single-base pair substitutions in genomic DNA.
Ali Saber Sichani, Maryam Ranjbar, Maryam Baneshi, Farid Torabi Zadeh, Jafar Fallahi   +4 more
openaire   +2 more sources

CRISPR-Cas9 DNA Base-Editing and Prime-Editing [PDF]

International Journal of Molecular Sciences, 2020
Many genetic diseases and undesirable traits are due to base-pair alterations in genomic DNA. Base-editing, the newest evolution of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-based technologies, can directly install point-mutations in cellular DNA without inducing a double-strand DNA break (DSB).
Mark M Hassall, Michelle E McClements, Robert E Maclaren   +2 more
exaly   +3 more sources