Results 241 to 250 of about 515,050 (293)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Mini-Catalytically Inactive Cas13X-Derived RNA Base Editing of β-Catenin Attenuates Pulmonary Damage in a Murine Acute Lung Injury Model. [PDF]

MedComm (2020)
Liu W, Bi W, Hou S, Du J, Zeng L, Zhang A, Zhang H, Wen D, Cai Q, Gao C, Lin P, Wu M, Li L, Jiang J.   +13 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs. [PDF]

Nat Chem Biol
Smargon AA, Pant D, Gomberg TA, Fagre C, Glynne S, Nguyen J, Naritomi JT, Gilbert WV, Yeo GW.   +8 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

In vivo mitochondrial base editing restores genotype and visual function in a mouse model of LHON. [PDF]

Nat Commun
Kim S, Kim J, Cha S, Ju S, Lim CJ, Hong S, Bae J, Oh Y, Jung S, Kim SP, Shin HS, Yoon JH, Park J, Ryou S, Lim SY, Lee SB, Choi SH, Park SJ, Choi CG, Choi M, Kim LK, Park J, Lee S, Seo KY, Seong JK, Kim K, Kim JS, Lee H.   +27 more
europepmc   +1 more source

Research progress of base editing and prime editing tools based on the CRISPR/Cas system. [PDF]

Mol Ther Nucleic Acids
Gao H, Gao S, Kan G, Valentovich LN, An Y.   +4 more
europepmc   +1 more source

Correction: Targeted C-to-T Base Editing in the Arabidopsis Plastid Genome. [PDF]

Curr Protoc
Nakazato I, Arimura SI.
europepmc   +1 more source

Comparative analysis of CRISPR-Cas9, lentiviral transduction, and base editing for sickle cell disease in a murine model. [PDF]

Blood Adv
Butt H, Sathish S, London E, Le A, Li Q, Gudmundsdottir B, Lee DY, Burke EV, Yates BP, Liu DR, Hsieh M, Leonard A, Eaton WA, Uchida N, Pierciey FJ, Newby GA, Tisdale JF, Demirci S.   +17 more
europepmc   +1 more source

Base editing strategies for <i>in vivo</i> correction of two highly recurrent phenylketonuria variants. [PDF]

Mol Ther Nucleic Acids
Quigley A, Jindal I, Campion T, Rutherford D, Han Y, Quigley W, Qu P, Musunuru K, Ahrens-Nicklas R, Hong X, Wang X.   +10 more
europepmc   +1 more source