Results 231 to 240 of about 967,825 (378)

Cytosine deamination and base excision repair cause R-loop–induced CAG repeat fragility and instability in Saccharomyces cerevisiae

Proceedings of the National Academy of Sciences of the United States of America, 2017
Xiaofeng A. Su, C. Freudenreich
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Base-excision repair pathway shapes 5-methylcytosine deamination signatures in pan-cancer genomes. [PDF]

Nat Commun
Silveira AB, Houy A, Ganier O, Özemek B, Vanhuele S, Vincent-Salomon A, Cassoux N, Mariani P, Pierron G, Leyvraz S, Rieke D, Picca A, Bielle F, Yaspo ML, Rodrigues M, Stern MH.   +15 more
europepmc   +1 more source

PARP1 Gene Knockout Suppresses Expression of DNA Base Excision Repair Genes. [PDF]

Dokl Biochem Biophys, 2023
Zakharenko AL, Malakhova AA, Dyrkheeva NS, Okorokova LS, Medvedev SP, Zakian SM, Kabilov MR, Tupikin AA, Lavrik OI.   +8 more
europepmc   +1 more source

5-Chloro-2′-deoxyuridine cytotoxicity results from base excision repair of uracil subsequent to thymidylate synthase inhibition

, 2000
Mark L Brandon, Li-Jun Mi, Wenren Chaung, George W. Teebor, Robert J. Boorstein   +4 more
openalex   +1 more source

A quantitative model of human DNA base excision repair. I. mechanistic insights [PDF]

, 2002
Bahrad A. Sokhansanj
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

The adaptive imbalance in base excision–repair enzymes generates microsatellite instability in chronic inflammation [PDF]

, 2003
Lorne J. Hofseth, Khan Ma, Mark Ambrose, Olga Nikolayeva, Meng Xu‐Welliver, Maria Kartalou, S. Perwez Hussain, Richard B. Roth, Xiaoling Zhou, Leah E. Mechanic, Irit Zurer, Varda Rotter, Leona D. Samson, Curtis C. Harris   +13 more
openalex   +2 more sources

TORC2 inhibition triggers yeast chromosome fragmentation through misregulated Base Excision Repair of clustered oxidation events. [PDF]

Nat Commun
Shimada K, Tarashev CVD, Bregenhorn S, Gerhold CB, van Loon B, Roth G, Hurst V, Jiricny J, Helliwell SB, Gasser SM.   +9 more
europepmc   +1 more source

Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair. [PDF]

Clin Cancer Res, 2023
Solta A, Boettiger K, Kovács I, Lang C, Megyesfalvi Z, Ferk F, Mišík M, Hoetzenecker K, Aigner C, Kowol CR, Knasmueller S, Grusch M, Szeitz B, Rezeli M, Dome B, Schelch K.   +15 more
europepmc   +1 more source