Results 251 to 260 of about 967,825 (378)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Human CST Stimulates Base Excision Repair to Prevent the Accumulation of Oxidative DNA Damage. [PDF]

J Mol Biol
Wysong BC, Schuck PL, Sridharan M, Carrison S, Murakami Y, Balakrishnan L, Stewart JA.   +6 more
europepmc   +1 more source

The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates. [PDF]

Int J Mol Sci, 2023
Bakman AS, Boichenko SS, Kuznetsova AA, Ishchenko AA, Saparbaev M, Kuznetsov NA.   +5 more
europepmc   +1 more source

The genotype distribution of the XRCC1gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia [PDF]

, 2002
Claire Seedhouse, Rowena D. Bainton, Michael D. Lewis, A. Lynn Harding, Nigel H. Russell, Emma Das‐Gupta   +5 more
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Molecular basis and functional consequences of the interaction between the base excision repair DNA glycosylase NEIL1 and RPA. [PDF]

J Biol Chem
Le Meur RA, Pecen TJ, Le Meur KV, Nagel ZD, Chazin WJ.   +4 more
europepmc   +1 more source

Assay conditions for estimating differences in base excision repair activity with Fpg-modified comet assay. [PDF]

Cell Biol Toxicol, 2023
Zheng C, Collins A, Brunborg G, van Schooten FJ, Nordengen AL, Shaposhnikov S, Godschalk R.   +6 more
europepmc   +1 more source

Flap Endonuclease 1 Efficiently Cleaves Base Excision Repair and DNA Replication Intermediates Assembled into Nucleosomes [PDF]

, 2002
Christine F. Huggins, David Chafin, Sayura Aoyagi, Leigh A. Henricksen, Robert A. Bambara, Jeffrey J. Hayes   +5 more
openalex   +1 more source

A new sub‐pathway of long‐patch base excision repair involving 5′ gap formation

EMBO Journal, 2017
Jordan Woodrick, Suhani Gupta, Sharon Camacho, Swetha Parvathaneni, S. Choudhury, A. Cheema, Yi Bai, Pooja Khatkar, Hayriye V. Erkizan, Furqan Sami, Yan Su, O. Schärer, Sudha Sharma, R. Roy   +13 more
semanticscholar   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, Volume 19, Issue 5, Page 1493-1507, May 2025.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source