Results 281 to 290 of about 967,825 (378)

HMGB2 is a biomarker associated with poor prognosis promoting radioresistance in glioma by targeting base excision repair pathway. [PDF]

Transl Oncol
Han W, Zhou H, Zhang X, Li H, Han X, Su L, Tian L, Xue X.   +7 more
europepmc   +1 more source

NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment

FEBS Open Bio, Volume 15, Issue 4, Page 661-673, April 2025.
Compared to normal tissues, NPC1 expression is significantly elevated in hepatocellular carcinoma tissues. Our findings indicate that NPC1 plays a key role in regulating neutrophil recruitment within the tumor, which is a critical factor in the progression of hepatocellular carcinoma and is closely linked to poor patient outcomes.
Songhai Yang, Jiangming Chen, Kun Xie, Fubao Liu   +3 more
wiley   +1 more source

Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation. [PDF]

Nat Commun
Schwarz SD, Xu J, Gunasekera K, Schürmann D, Vågbø CB, Ferrari E, Slupphaug G, Hottiger MO, Schär P, Steinacher R.   +9 more
europepmc   +1 more source

Base excision repair synthesis of DNA containing 8-oxoguanine in Escherichia coli [PDF]

, 2003
Yun‐Song Lee, Myung‐Hee Chung
openalex   +1 more source

Synergistic antibacterial activity of baicalin in combination with oxacillin sodium against methicillin‐resistant Staphylococcus aureus

FEBS Open Bio, Volume 15, Issue 4, Page 608-621, April 2025.
The bacterial cell membrane and cell wall are the primary targets of baicalin. Baicalin increases the permeability of bacterial membranes, allowing oxacillin sodium to easily penetrate the cells and effectively exert its antimicrobial activity. Methicillin‐resistant Staphylococcus aureus (MRSA) poses a challenge for clinical treatment and combining ...
Xin Meng, Mengna Kang, Zhiyun Yu, Changyou Li, Yang Chen, Taicheng Jin, Kai Wang, Haiyong Guo   +7 more
wiley   +1 more source

Dysregulation of base excision repair factors associated with low tumor immunogenicity in head and neck cancer: implication for immunotherapy. [PDF]

Ther Adv Med Oncol
Shpilman Z, Kidane D.
europepmc   +1 more source

Real‐world genomic landscape of colon and rectal cancer

FEBS Open Bio, Volume 15, Issue 4, Page 674-685, April 2025.
We confirmed enrichment of RTK alterations in patients with RAS/BRAF‐wt tumors and of PI3K pathway alterations in RAS/BRAF‐altered tumors with 51 982 real‐world tissue comprehensive genomic profiling (CGP) samples in CRC. In a subset of 140 patients with both tissue and liquid results, the sensitivity of liquid for results found by tissue was 100% when
Markus Schulze, XiaoZhe Wang, Jawad Hamad, Julia C. F. Quintanilha, Lincoln W. Pasquina, Julia F. Hopkins, Juergen Scheuenpflug, Zheng Feng   +7 more
wiley   +1 more source

Protection of Human Lung Cells against Hyperoxia Using the DNA Base Excision Repair Genes hOgg1 and Fpg

, 2002
Min Wu, Ying-Hui He, Masayoshi Kobune, Yi Xu, Mark R. Kelley, William J. Martin   +5 more
openalex   +2 more sources

Cost‐effective and simple flow cytometry quantification of receptor‐mediated autophagy using fluorescent tagging

FEBS Open Bio, Volume 15, Issue 4, Page 587-598, April 2025.
Mitophagy, the selective degradation of damaged mitochondria, is crucial for cellular health and function. This study introduces a rapid and efficient flow cytometry method using GFP‐BNIP3L/NIX to accurately quantify mitophagy. Our approach can be adapted to use any fluorescent‐tagged selective autophagy receptor, enabling direct and rapid analysis of ...
Mija Marinković, Ana Rožić, Denis Polančec, Ivana Novak   +3 more
wiley   +1 more source

Impact of DNA ligase 1 and IIIα interactions with APE1 and polβ on the efficiency of base excision repair pathway at the downstream steps. [PDF]

J Biol Chem
Almohdar D, Murcia D, Tang Q, Ortiz A, Martinez E, Parwal T, Kamble P, Çağlayan M.   +7 more
europepmc   +1 more source