Results 81 to 90 of about 967,825 (378)
Chemical Biology of Mammalian DNA Repair
CHIMIA, 2001 Damage to the heterocyclic bases of DNA in the genome is mainly corrected by the base excision repair (BER) or nucleotide excision repair (NER) pathways.
Orlando D. Schärer
doaj +2 more sources
The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans
Frontiers in Cell and Developmental Biology, 2020 Exogenous and endogenous damage to the DNA is inevitable. Several DNA repair pathways including base excision, nucleotide excision, mismatch, homologous and non-homologous recombinations are conserved across all organisms to faithfully maintain the ...
Noha Elsakrmy +2 more
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Base Excision Repair Pathways [PDF]
, 2011 DNA repair is a process vital to the cell since the genetic material is the target of a multitude of daily attacks. Cells have evolved into possessing distinct but simultaneously intercalating ways of dealing with repair of DNA lesions. These repair pathways may include practices dealing with single strand damage (Base Excision Repair, Nucleotide ...
openaire +3 more sources
FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
RAS transformation requires CUX1-dependent repair of oxidative DNA damage.
PLoS Biology, 2014 The Cut homeobox 1 (CUX1) gene is a target of loss-of-heterozygosity in many cancers, yet elevated CUX1 expression is frequently observed and is associated with shorter disease-free survival.
Zubaidah M Ramdzan +12 more
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High-resolution mapping demonstrates inhibition of DNA excision repair by transcription factors
eLife, 2022 DNA base damage arises frequently in living cells and needs to be removed by base excision repair (BER) to prevent mutagenesis and genome instability.
Mingrui Duan +7 more
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Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine +3 more
wiley +1 more source
Journal of Nucleic Acids, 2010 DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision ...
Rihito Morita +9 more
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Mechanisms of glycosylase induced genomic instability. [PDF]
PLoS ONE, 2017 Human alkyladenine DNA glycosylase (AAG) initiates base excision repair (BER) to guard against mutations by excising alkylated and deaminated purines. Counterintuitively, increased expression of AAG has been implicated in increased rates of spontaneous ...
Daniel E Eyler +3 more
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Xeroderma Pigmentosum Complementation Group C (XPC): Emerging Roles in Non-Dermatologic Malignancies
Frontiers in Oncology, 2022 Xeroderma pigmentosum complementation group C (XPC) is a DNA damage recognition protein essential for initiation of global-genomic nucleotide excision repair (GG-NER).
Nawar Al Nasrallah +3 more
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