Results 61 to 70 of about 353,589 (332)
Base pair probability estimates improve the prediction accuracy of RNA non-canonical base pairs. [PDF]
PLoS Computational Biology, 2017 Prediction of RNA tertiary structure from sequence is an important problem, but generating accurate structure models for even short sequences remains difficult.
Michael F Sloma, David H Mathews
doaj +1 more source
Statistical mechanics of base stacking and pairing in DNA melting
, 2004 We propose a statistical mechanics model for DNA melting in which base stacking and pairing are explicitly introduced as distinct degrees of freedom. Unlike previous approaches, this model describes thermal denaturation of DNA secondary structure in the ...
A. Montrichok +8 more
core +1 more source
Theory of phase segregation in DNA assemblies containing two different base pair sequence types [PDF]
, 2016 Spontaneous pairing of homologous DNA sequences – a challenging subject in molecular biophysics, often referred to as ‘homology recognition’ – ha s been observed in vitro for several DNA system s a . One of th e se experiments involved liquid crystalline
Kornyshev, AA, Lee, DJ, Wynveen, A
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Pd2 +-mediated base pairing in oligonucleotides
, 2016 International audienceTwo short glycol nucleic acid (GNA) oligonucleotides, having either a terminal or an intrachain nucleobase replaced by the pyridine-2,6-dicarboxamide chelate of Pd2 +, have been synthesized and their hybridization properties studied
Golubev, Oleg +2 more
core +3 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Base‐Filling in Double‐Helical Nucleic Acids
ChemistryOpenBase‐filling, i. e., post‐synthetic furnishing of an oligonucleotide scaffold with base moieties or their analogues, is an interesting alternative to the conventional approach of sequential coupling of building blocks (modified or otherwise).
Mark Nana Kwame Afari, Tuomas Lönnberg
doaj +1 more source
Deligne's duality for de Rham realizations of 1-motives
, 2008 We show that the pairing on de Rham realizations of 1-motives in "Theorie di Hodge III", IHES 44, can be defined over any base scheme and we prove that it gives rise to a perfect duality if one is working with a 1-motive and its Cartier dual. Furthermore
Andreatta, Coleman, Coleman, Raynaud
core +1 more source
Solving discrete logarithms on a 170-bit MNT curve by pairing reduction [PDF]
, 2016 Pairing based cryptography is in a dangerous position following the breakthroughs on discrete logarithms computations in finite fields of small characteristic.
A Commeine +33 more
core +5 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source