Results 61 to 70 of about 28,547,466 (259)
FEBS Letters, EarlyView.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2014 Significance Translation of hepatitis C virus (HCV) RNA is facilitated by an internal ribosome entry site (IRES) that binds small (40S) ribosomal subunits via ribosomal protein and 18S ribosomal RNA (rRNA) interactions.
Daiki Matsuda, V. Mauro
semanticscholar +1 more source
Single-flavour and two-flavour pairing in three-flavour quark matter [PDF]
J.Phys. G32 (2006) 511-528, 2005 We study single-flavour quark pairing ("self-pairing") in colour-superconducting phases of quark matter, paying particular attention to the difference between scenarios where all three flavours undergo single-flavour pairing, and scenarios where two flavours pair with each other ("2SC" pairing) and the remaining flavour self-pairs.
arxiv +1 more source
A grafting strategy for the design of improved G-quadruplex aptamers and high-activity DNAzymes. [PDF]
PLoS ONE, 2009 Nucleic acid aptamers are generally obtained by in vitro selection. Some have G-rich consensus sequences with ability to fold into the four-stranded structures known as G-quadruplexes.
Tao Li, Erkang Wang, Shaojun Dong
doaj +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Hierarchies and Ranks for Persistence Pairs [PDF]
, 2019 We develop a novel hierarchy for zero-dimensional persistence pairs, i.e., connected components, which is capable of capturing more fine-grained spatial relations between persistence pairs. Our work is motivated by a lack of spatial relationships between features in persistence diagrams, leading to a limited expressive power.
arxiv +1 more source
FEBS Letters, EarlyView.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
Journal of the American Chemical Society, 2014 The chemical synthesis of ribonucleic acids (RNA) with novel chemical modifications is largely driven by the motivation to identify eligible functional probes for the various applications in life sciences.
M. Košutić +7 more
semanticscholar +1 more source
Semi-regular biorthogonal pairs and generalized Riesz bases [PDF]
, 2016 In this paper we define the notion of semi-regular biorthogonal pairs what is a generalization of regular biorthogonal pairs in Ref. \cite{hiroshi1} and show that if $(\{ \phi_{n} \} , \{ \psi_{n} \})$ is a semi-regular biorthogonal pair, then $\{ \phi_{n} \}$ and $\{ \psi_{n} \}$ are generalized Riesz bases.
arxiv +1 more source
Video Moment Retrieval with Text Query Considering Many-to-Many Correspondence Using Potentially Relevant Pair [PDF]
arXiv, 2021 In this paper we undertake the task of text-based video moment retrieval from a corpus of videos. To train the model, text-moment paired datasets were used to learn the correct correspondences. In typical training methods, ground-truth text-moment pairs are used as positive pairs, whereas other pairs are regarded as negative pairs.
arxiv