Results 231 to 240 of about 905,353 (315)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Advances in gene therapy for mitochondrial genetic disorders: current status and clinical implementation challenges. [PDF]

J Transl Med
Lyu L, Qie B, He Y, Chen F, Liu B.
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

RNA inverse folding can be solved in linear time for structures without isolated stacks or base pairs. [PDF]

Algorithms Mol Biol
Boury T, Gardelle S, Bulteau L, Ponty Y.
europepmc   +1 more source

On sequence-based closed form entries for an exponentiated general $2 \times 2$ matrix: A re-formulation and an application.

, 2017
Peter J. Larcombe, Eric J. Fennessey
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Synovial folds of the lateral atlantoaxial joints in dogs: a magnetic resonance, anatomic, and histologic study. [PDF]

Front Vet Sci
Burg-Personnaz JB, Kaessmeyer S, Forterre F, Precht C, Haenssgen K.   +4 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Complete genome sequence of <i>Arthrobacter globiformis</i> bacteriophage Powelldog. [PDF]

MicroPubl Biol
Desai Z, Foret N, Godwin SL, Huffmon HB, Kim JY, McGuirt LY, Richardson SA, Robles Gonzalez J, Signorelli D, Siyum H, Vallejo A, Wigren SR, Bullock SK, Pass MB, Wisner EM, Bates TC.   +15 more
europepmc   +1 more source

Data for: Non-parametric Sequence-based learning Approach for Outlier Detection in IoT

, 2017
Nashreen Nesa
openalex   +1 more source