Results 61 to 70 of about 842,010 (246)

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Origin of life: β‐sheet amyloid conformers as the primordial functional polymers on the early Earth and their role in the emergence of complex dynamic networks

open access: yesFEBS Letters, EarlyView.
The amyloid world hypothesis of the origin‐of‐life posits that the first functional polymers on the early Earth were structurally stable cross‐β‐sheet‐based peptide amyloids capable of Darwinian‐like evolution. Peptide amyloids display self‐replication and information transfer, as well as catalytic, adaptive, and evolutive properties.
Carl Peter J. Maury
wiley   +1 more source

The complete mitogenome and phylogenetic analysis of Japanese firefly ‘Genji Botaru’ Luciola cruciata (Coleoptera: Lampyridae)

open access: yesMitochondrial DNA. Part B. Resources, 2017
We performed mitogenome analysis of Japanese firefly Luciola cruciata (Coleoptera: Lampyridae), which is unique species in Japan. It is classified into six haplotypes based on the difference of COII sequence on mitochondrial DNA.
Juri Maeda   +5 more
doaj   +1 more source

Evolution regularity of the Neogene shallow water delta in the Laibei area Bohai Bay Basin, northern China

open access: yesJournal of Palaeogeography, 2014
According to the characteristics of sedimentary microfacies, unique vertical depositional sequences and well logging response, the authors propose that a shallow water delta was widely developed in the Neogene of the Laibei area, Bohai Bay Basin of ...
Jian-Ping Li   +3 more
doaj   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Key controls of the gas and oil preferences of China's major coal-bearing sequences

open access: yesPetroleum Exploration and Development, 2009
The key controls on the gas and oil preferences of coal-bearing strata are discussed from the relationship of material foundation between coal formation and hydrocarbon generation, the variation of the initial gas to oil ratio (GOR) of organic matter in ...
Zhong Ningning, Chen Gongyang
doaj   +1 more source

Synchronizable Checking Sequences Based on UIO Sequences [PDF]

open access: yes, 1996
This study addresses the synchronization problem that arises during the application of a predetermined checking sequence in some protocol test architectures that utilize remote testers. The synchronization problem can usually be solved by adding an additional communication channel or an additional protocol for coordination between the remote testers ...
S. Guyot, Hasan Ural
openaire   +2 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

High-throughput sequencing of core STR loci for forensic genetic investigations using the Roche Genome Sequencer FLX platform

open access: yesBioTechniques, 2011
The analysis and profiling of short tandem repeat (STR) loci is routinely used in forensic genetics. Current methods to investigate STR loci, including PCR-based standard fragment analyses and capillary electrophoresis, only provide amplicon lengths that
Sarah L. Fordyce   +9 more
doaj   +1 more source

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