Results 71 to 80 of about 2,107,603 (337)
Traversing the basement membrane in vivo: A diversity of strategies
Journal of Cell Biology, 2014 The basement membrane is a dense, highly cross-linked, sheet-like extracellular matrix that underlies all epithelia and endothelia in multicellular animals.
L. C. Kelley +3 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Basement membranes and human disease [PDF]
Cell and Tissue Research, 2009 In 1990, the role of basement membranes in human disease was established by the identification of COL4A5 mutations in Alport's syndrome. Since then, the number of diseases caused by mutations in basement membrane components has steadily increased as has our understanding of the roles of basement membranes in organ development and function.
Tom Van Agtmael +2 more
openaire +4 more sources
Discovery of Basement Membrane Components [PDF]
Journal of Investigative Dermatology, 2008 The dermal–epidemal basement membrane can arguably be said to be the most well studied of all basement membranes, and is a structure that plays an important role in cutaneous biology. While the discovery of genes coding for basement membrane components has provided exciting advances in our understanding of the basement membrane zone, it is easy to ...
openaire +3 more sources
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source
Invadopodia and basement membrane invasion in vivo
Cell Adhesion & Migration, 2014 Over 20 years ago, protrusive, F-actin-based membrane structures, termed invadopodia, were identified in highly metastatic cancer cell lines. Invadopodia penetrate artificial or explanted extracellular matrices in 2D culture conditions and have been ...
Lauren R. L. Lohmer +3 more
semanticscholar +1 more source
Structure and Function of Basement Membrane.
Journal of Investigative Dermatology, 1982 Progress has been made in identifying and characterizing basement membrane macromolecules, including type IV collagen, laminin, a heparan sulfate proteoglycan and bullous pemphigoid antigen. Basement membrane contains a unique collagen, type IV collagen, which is formed of pro alpha 1(IV) (Mr = 185,000) and pro alpha 2(IV) (Mr = 170,000) chains.
John R. Stanley +3 more
openaire +3 more sources
Pharmaceuticals, 2020 Breast cancer progression is marked by cancer cell invasion and infiltration, which can be closely linked to sites of tumor-connected basement membrane thinning, lesion, or infiltration.
Tabea Wiedenhoeft +6 more
doaj +1 more source
Aging and Cancer, EarlyView.Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley +1 more source
UDP‐glucose dehydrogenase variants cause dystroglycanopathy
Annals of Clinical and Translational Neurology, EarlyView.Abstract UDP‐glucose dehydrogenase (UGDH) variants have been associated with hypotonia, developmental delay, and epilepsy. We report the first pathologic evidence of dystroglycanopathy in siblings with UGDH variants. Both presented around 6 months with developmental delay and elevated creatinine kinase.
Anna M. Reelfs +8 more
wiley +1 more source