Results 51 to 60 of about 282,340 (392)

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation

Journal of Cell Biology, 1988
Cultured bovine capillary endothelial (BCE) cells were found to synthesize and secrete high molecular mass heparan sulfate proteoglycans and glycosaminoglycans, which bound basic fibroblast growth factor (bFGF).
O. Saksela, D. Moscatelli, A. Sommer, D. Rifkin   +3 more
semanticscholar   +1 more source

Role of Basic Fibroblast Growth Factor in Cancer: Biological Activity, Targeted Therapies, and Prognostic Value

Cells, 2023
Cancer is the leading cause of death worldwide; thus, it is necessary to find successful strategies. Several growth factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF, FGF2), and transforming growth factor ...
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alberto Repici, Marika Lanza, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti   +10 more
doaj   +1 more source

Basic Fibroblast Growth Factor: Serum Levels in the Female

Growth Factors, 2000
This study investigated serum levels of basic fibroblast growth factor (b FGF), a potent angiogenic factor, during distinct periods of the female life and compared them with corresponding levels in age-matched males. Healthy females (n = 59) and males (n = 53) were included in the study, divided into six groups: fetuses (cord blood), neonates, children,
Malamitsi-Puchner, A, Tziotis, J, Tsonou, A, Protonotariou, E, Sarandakou, A, Creatsas, G   +5 more
openaire   +3 more sources

The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases (*)

Journal of Biological Chemistry, 1996
Perlecan is a modular heparan sulfate proteoglycan that is localized to cell surfaces and within basement membranes. Its ability to interact with basic fibroblast growth factor (bFGF) suggests a central role in angiogenesis during development, wound ...
J. Whitelock, A. Murdoch, R. Iozzo, Underwood Pa   +3 more
semanticscholar   +1 more source

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source

Experimental therapy of chronic kidney ischemia using drug basic fibroblast growth factor

Український Журнал Нефрології та Діалізу, 2022
. The aim of the work was to experimentally study the effect of the created injectable drug basic fibroblast growth factor (bFGF) with the controlled release on morphological changes and indicators of renospecific enzymes in the ischemic kidney ...
S. Bazalytska, G. Nikulina, V. Kordium, I. Dubey, S. Vozianov, A. Romanenko, Ia. Pokholenko, S. Nikitaev, I. Serbina, L. Mygal, O. Vozianov   +10 more
doaj   +1 more source

The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies.

, 2007
Basic fibroblast growth factor/fibroblast growth factor-2 is one of the best characterized of the pro-angiogenic cytokines. This review describes its history, as well as its role in tumor angiogenesis associated with haematological malignancies, as ...
RUSNATI, Marco, VACCA A, RIBATTI D, PRESTA, Marco   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basic fibroblast growth factor sustained-release system promotes neurogenesis and tissue repair after spinal cord injury

Neural Regeneration Research
Spinal cord injury is accompanied by a substantial loss of neurons. Cell replacement therapy improves motor and sensory dysfunction by replacing dead neurons, and endogenous neurogenesis is an important cell replacement source.
Xuyang Fu, Hongmei Duan, Boya Zhang, Huan Wang, Yulin Bi, Miaoxin Yu, Peng Hao, Jian Sun, Dapeng Li, Yudan Gao, Wen Zhao, Xiaoxuan Liu, Zhaoyang Yang, Xiaoguang Li   +13 more
doaj   +1 more source

13-Methyltetradecanoic acid mitigates cerebral ischemia/reperfusion injury

Neural Regeneration Research, 2016
13-Methyltetradecanoic acid can stabilize cell membrane and have anti-inflammatory, antioxidant and anti-apoptotic effects. Previous studies mainly focused on peripheral nerve injury, but seldom on the central nervous system.
Juan Yu, Li-nan Yang, Yan-yun Wu, Bao-hua Li, Sheng-mei Weng, Chun-lan Hu, Yong-ling Han   +6 more
doaj   +1 more source