Results 41 to 50 of about 113,312 (290)
Frontiers in Immunology, 2023 Basophils crucially contribute to allergies and other Th2-driven diseases by rapidly releasing inflammatory and immunomodulatory mediators following high-affinity IgE-receptor crosslinking.
Anette T. Hansen Selnø +3 more
doaj +1 more source
Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]
, 2015 Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Abooali, Maryam +8 more
core +3 more sources
Contribution of basophils to cutaneous immune reactions and Th2-mediated allergic responses
Frontiers in Immunology, 2015 Basophils are potent effector cells of innate immunity and also play a role in T helper 2 (Th2)-mediated allergic responses. But, although their in vitro functions are well studied, their in vivo functions remain largely unknown.
Atsushi eOtsuka, Kenji eKabashima
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Background: Altered basophil identification markers have been discovered to associate with allergic asthma (AA) in recent years. However, little is known about the expression of basophil markers in blood granulocytes.Aim: To parallel test blood basophils
Hua Xie +11 more
doaj +1 more source
Immunity, 2008 In this issue of Immunity, Tsujimura et al. (2008) report that the release of platelet-activating factor by basophils stimulated with immunoglobulin G1 (IgG1)-antigen immune complexes contributes substantially to the expression of an IgG1-dependent alternative pathway of systemic anaphylaxis in mice.
Galli, Stephen J. +1 more
openaire +2 more sources
Mast cell clones: a model for the analysis of cellular maturation. [PDF]
, 1982 Cloned mouse mast cells resemble, by ultrastructure, immature mast cells observed in vivo. These mast cell clones can be grown in the absence of any other cells, facilitating direct investigations of their biochemistry and function.
Cantor, H +10 more
core +2 more sources
Clinical and Translational Significance of Basophils in Patients with Cancer
Cells, 2022 Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as ...
Jitesh Chauhan +8 more
doaj +1 more source
Antibodies and IL-3 support helminth-induced basophil expansion [PDF]
, 2012 Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely ...
Bourquin, Carole +14 more
core +1 more source
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
Applying Surface Plasmon Resonance to Monitor the IgE-Mediated Activation of Human Basophils
Allergology International, 2008 Background: The histamine releasing test which detects histamine released from basophils in vitro is safe, sensitive and widely used for clinical examination in the field of allergy.
Hidenori Suzuki +5 more
doaj +1 more source