Results 1 to 10 of about 1,964 (169)

Identification of a New and Effective Marker Combination for a Standardized and Automated Bin-Based Basophil Activation Test (BAT) Analysis [PDF]

Diagnostics
(1) Background: The basophil activation test (BAT) is a functional whole blood-based ex vivo assay to quantify basophil activation after allergen exposure by flow cytometry.
Andreas Radbruch, Yen Hoang, Margitta Worm   +2 more
exaly   +6 more sources

The Basophil Activation Test in Allergy Diagnostics: Clinical Applications, Methodological Challenges, and Proposed Clinical Frameworks [PDF]

Cells
The basophil activation test (BAT) is a modern in vitro functional assay used for the diagnosis of immunoglobulin E-mediated allergic reactions. The method is based on flow cytometric assessment of activation marker expression on peripheral blood ...
Marina Izmailovich, Aizhan Kabyldina, Zamira Seilkhan, Aruzhan Zhussip, Raushan Kozhanova, Tair Nurpeissov, Gulzada Uteubaeva, Olga Kazimirova, Alyona Lavrinenko, Lyubov Brizitskaya, Elina Suleimanova, Zarina Shaikhina   +11 more
doaj   +2 more sources

IgE levels correlate with FcεRI expression on circulatory basophils but not with their activation response in patients with Hymenoptera anaphylaxis [PDF]

Frontiers in Allergy
BackgroundMeasurement of IgE levels, skin prick tests (SPT), and basophil activation tests (BAT) are the gold standards for diagnosing Hymenoptera allergy. Currently, BAT most accurately resembles patient reactivity. However, data examining the influence
Stefan Aigner, Stefan Aigner, Viktoria Puxkandl, Viktoria Puxkandl, Teresa Burner, Teresa Burner, Angelika Lackner, Angelika Lackner, Sherezade Moñino-Romero, Sherezade Moñino-Romero, Ana Maria Giménez-Arnau, Susanne Kimeswenger, Susanne Kimeswenger, Michael Gabriel, Wolfram Hoetzenecker, Wolfram Hoetzenecker, Wolfram Hoetzenecker, Sabine Altrichter, Sabine Altrichter, Sabine Altrichter, Sabine Altrichter, Sabine Altrichter   +21 more
doaj   +2 more sources

Efficacy predictions for omalizumab treatment based on basophil CD203c expression in patients with allergic rhinitis by basophil activation test -- a real-life, pilot study [PDF]

World Allergy Organization Journal
Background: Basophils are key targets in allergic diseases. Omalizumab blocks IgE binding to FcεRI on basophils, reducing allergic responses. The basophil activation test aids allergy diagnosis, but their role in allergic rhinitis (AR) remains unclear ...
Zhan Zhao, MD, Huidong Chen, MD, Tianyi Liu, MD, Jun Hong, MD, Yuqin Deng, MD, Qingquan Hua, MD   +5 more
doaj   +2 more sources

Association between results of component-resolved diagnostics and basophil activation in Hymenoptera venom allergy: A registry-based cross-sectional study in adults. [PDF]

PLoS ONE
BackgroundAllergy to Hymenoptera venom is one of the most frequent causes of anaphylaxis in adults. Conventional diagnostic approaches, including skin testing and measurement of allergen-specific IgE (sIgE) to venom extracts, do not always allow for ...
Krzysztof Łukasz Piwowarek, Krzysztof Kłos, Elżbieta Rutkowska, Andrzej Chciałowski, Agata Raniszewska-Borys, Iwona Kwiecień, Jerzy Kruszewski   +6 more
doaj   +2 more sources

Standardizing a Four-Marker Basophil Activation Test: Influence of Storage Time, Temperature, and IgE Levels [PDF]

Journal of Asthma and Allergy
WeiZe Li,1,2,* XuanYue Qu,1,* LiHui Lin,1 Juan Wang,1 Jia Li,1 Yue Yin,1 YiQin Ge,1,3 JinYan Zhao,1 Yi Liu,4 Li Li,1 Xia Peng1 1Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine,
Li W, Qu X, Lin L, Wang J, Li J, Yin Y, Ge Y, Zhao J, Liu Y, Li L, Peng X   +10 more
doaj   +2 more sources

Clinical applications of basophil activation test: a review [PDF]

Yixue xinzhi zazhi, 2022
Basophils are one of the most important effector cells involved in IgE-mediated type I hypersensitivity and type 2 inflammation. Basophil activation test (BAT) simulates in vivo type I hyper-sensitivity.
Ya-Dong GAO, Jin-Jin ZHANG, Guang-Hui LIU   +2 more
doaj   +1 more source

What Basophil Testing Tells Us About CSU Patients – Results of the CORSA Study

Frontiers in Immunology, 2021
Basophil testing is the most effective single approach for diagnosing type-IIb autoimmune chronic spontaneous urticaria (TIIbaiCSU). A positive basophil test has been linked to long disease duration, higher disease activity, a poor response to ...
João Marcelino, Katrine Baumann, Katrine Baumann, Katrine Baumann, Per Stahl Skov, Per Stahl Skov, Maria Conceição Pereira Santos, Inga Wyroslak, Jörg Scheffel, Jörg Scheffel, Sabine Altrichter, Sabine Altrichter, Anders Woetmann, Anders Woetmann, Manuel Pereira-Barbosa, Célia Costa, Marcus Maurer, Marcus Maurer   +17 more
doaj   +1 more source

Clinical and Translational Significance of Basophils in Patients with Cancer

Cells, 2022
Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as ...
Jitesh Chauhan, Chara Stavraka, Melanie Grandits, Lais C. G. F. Palhares, Debra H. Josephs, Katie E. Lacy, James Spicer, Heather J. Bax, Sophia N. Karagiannis   +8 more
doaj   +1 more source

The basophil activation test differentiates between patients with wheat‐dependent exercise‐induced anaphylaxis and control subjects using gluten and isolated gluten protein types

Clinical and Translational Allergy, 2021
Background Oral food challenge using gluten and cofactors is the gold standard to diagnose wheat‐dependent exercise‐induced anaphylaxis (WDEIA), but this procedure puts patients at risk of an anaphylactic reaction.
Angelika Miriam Gabler, Julia Gebhard, Bernadette Eberlein, Tilo Biedermann, Katharina Anne Scherf, Knut Brockow   +5 more
doaj   +1 more source