Results 51 to 60 of about 1,964 (169)

Applications of basophil activation test in paediatric allergic diseases

World Allergy Organization Journal
Basophilic granulocytes, containing and releasing histamine after a specific allergy stimulation, are directly involved in IgE-mediated allergic reactions.
Dodi Giulia, MD, Di Filippo Paola, MD, Di Ludovico Armando, MD, Simeone Pasquale, PhD, De Bellis Domenico, MSc, D'ascanio Francesca, MSc, Di Pillo Sabrina, MD, Chiarelli Francesco, PhD, Lanuti Paola, PhD, Attanasi Marina, PhD   +9 more
doaj   +1 more source

Subcutaneous Allergen Immunotherapy With Thermosensitive Hydrogel and Recombinant Birch Pollen Allergen Variant, a Randomised Controlled Trial

Clinical &Experimental Allergy, EarlyView.
A Phase 1, randomised, placebo‐controlled, dose‐escalation trial was performed with 30 birch pollen allergic subjects treated with DM‐101PX, that contains a recombinant hypoallergenic variant of Bet v 1 formulated with poloxamer 338 thermosensitive hydrogel.
Anna Nilson, Patricia Couroux, Jaana Haka, Silja Halme, Pekka Mattila, R. J. Joost van Neerven, Rolien Pels‐Rijcken, Janneke Ruinemans‐Koerts, Yvonne Schmidt‐Hieltjes, Anne Marie Salapatek, Kati Sallinen, Kristiina Takkinen, Daphne Tsitoura, Dirk‐Jan Opstelten, Juha Rouvinen   +14 more
wiley   +1 more source

Comparison of basophil activation testing and component-resolved diagnosis in patients with cross-reactive intradermal results after anaphylactic reactions to hymenoptera venom

Scientific Reports
Hymenoptera venom allergy (HVA) is a significant cause of anaphylaxis, with a broad spectrum of symptoms. Accurate diagnosis is critical for selecting appropriate venom immunotherapy (VIT), yet multiple sensitizations complicate the identification of the
Mohammad Hasan Bemanian, Negin Jafariaghdam, Faezeh Shahba, Mohammad Nabavi, Morteza Fallahpour, Sima Shokri, Fatemeh Faraji, Mohammad-Ali Assarehzadegan, Mehrnaz Mesdaghi, Hamideh Nodehi, Majid Khoshmirsafa   +10 more
doaj   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

Comparative analysis of immune responses in ovipositing and non‐ovipositing females of European earwig Analyse comparative de la réponse immunitaire avant et après la ponte chez le forficule européen

Physiological Entomology, EarlyView.
Oviposition and care decrease the total haemocyte concentration. Oviposition and care affect haemocyte type proportions. Serratia marcescens challenge does not affect the immune cell parameters. Abstract Reproduction and immunity are essential biological processes that compete for resources and energy.
Louis Pailler, Wilfrid Jean Louis, Mae Baillergeon, Marion Corjon, Tiffany Laverre, Julien Verdon, Joël Meunier, Christine Braquart‐Varnier   +7 more
wiley   +1 more source

T2-HIGH AND T2-LOW SEVERE ASTHMA: ROLE OF BASOPHIL ACTIVATION TEST (BAT) [PDF]

, 2022
Allergic disorders are one of the most common chronic diseases worldwide. Skin prick test and the measurement of immunoglobulin (Ig)E antibody are routinely used for the diagnosis of allergic disorders. However, skin prick test and serum IgE detect only sensitization but do not prove the clinical manifestations of allergic disease.
openaire  

Sesame Immunotherapy: A Systematic Review and Narrative Synthesis

Clinical and Translational Allergy, Volume 16, Issue 10, October 2026.
ABSTRACT Sesame allergy is associated with severe allergic reactions, low rates of spontaneous resolution, and significant psychosocial burden. Current management relies on strict avoidance and emergency treatment. Allergen‐specific immunotherapy, particularly oral immunotherapy (OIT), has emerged as a potential disease‐modifying approach, but evidence
Joanna Zielińska, Katarzyna Kunkiel, Anna Krupa‐Łaska, Marek Kulus, Katarzyna Grzela   +4 more
wiley   +1 more source

Dendrimeric Antigens for Drug Allergy Diagnosis: A New Approach for Basophil Activation Tests

Molecules, 2018
Dendrimeric Antigens (DeAns) consist of dendrimers decorated with multiple units of drug antigenic determinants. These conjugates have been shown to be a powerful tool for diagnosing penicillin allergy using in vitro immunoassays, in which they are ...
Noemi Molina, Angela Martin-Serrano, Tahia D. Fernandez, Amene Tesfaye, Francisco Najera, María J. Torres, Cristobalina Mayorga, Yolanda Vida, Maria I. Montañez, Ezequiel Perez-Inestrosa   +9 more
doaj   +1 more source

Bioassays in Allergy: Technical Characteristics, Limitations, and Pathways to Clinical Implementation—An EAACI Position Paper

Clinical and Translational Allergy, Volume 16, Issue 10, October 2026.
ABSTRACT Bioassays offer functional readouts of immune responses through specific biomarkers, providing mechanistic insight beyond conventional serology. By capturing cellular activation, tissue‐level changes, and molecular signaling, they hold promise for refining allergy diagnosis, risk stratification, and treatment monitoring, contributing to ...
Cagatay Karaaslan, Oscar Palomares, Busra Kilic, Cristobalina Mayorga, Hans Jürgen Hoffmann, Bernadette Eberlein, Edward Knol, Ruben Fernandez‐Santamaria, Joana Vitte, Elena Izquierdo, Cristina Gomez‐Casado, Marina Perez‐Gordo, Araceli Diaz Perales, Maria M. Escribese   +13 more
wiley   +1 more source

Allergenicity of α‐Gal‐Containing Products

Allergy, EarlyView.
Frederik Bloch Mangaard, Esben Eller, Per Stahl Skov, Charlotte G. Mørtz, Carsten Bindslev‐Jensen   +4 more
wiley   +1 more source