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Basophils exhibit antibacterial activity through extracellular trap formation
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing ...
Shida Yousefi +2 more
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European Journal of Pharmacology, 2016
Basophils are functionally closely related to mast cells. Both cell types express the high-affinity IgE receptor (FcεRI) and rapidly release preformed mediator from intracellular stores upon IgE-mediated activation. However, in contrast to mast cells basophils finish their maturation in the bone marrow and have a lifespan of only 2-3 days.
Christian, Schwartz +2 more
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Basophils are functionally closely related to mast cells. Both cell types express the high-affinity IgE receptor (FcεRI) and rapidly release preformed mediator from intracellular stores upon IgE-mediated activation. However, in contrast to mast cells basophils finish their maturation in the bone marrow and have a lifespan of only 2-3 days.
Christian, Schwartz +2 more
openaire +2 more sources
Nature Reviews Immunology, 2020
To keep tissue pathology at bay following nematode infection, basophils ensure that group 2 innate lymphoid cells can respond to neuron-derived signals to temper their activity.
Lucy Bird
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To keep tissue pathology at bay following nematode infection, basophils ensure that group 2 innate lymphoid cells can respond to neuron-derived signals to temper their activity.
Lucy Bird
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Southern Medical Journal, 1980
We have described a patient with basophilic leukemia secondary to chronic granulocytic leukemia. Symptoms of hyperhistaminemia were aggravated after chemotherapy with hydroxyurea. Antihistamines (H1 receptor antagonists) controlled many of the symptoms related to hyperhistaminemia.
C V, Jennings, C L, Dannaher, L T, Yam
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We have described a patient with basophilic leukemia secondary to chronic granulocytic leukemia. Symptoms of hyperhistaminemia were aggravated after chemotherapy with hydroxyurea. Antihistamines (H1 receptor antagonists) controlled many of the symptoms related to hyperhistaminemia.
C V, Jennings, C L, Dannaher, L T, Yam
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Specificity of Basophils and Lymphocytes in Cutaneous Basophil Hypersensitivity
The Journal of Immunology, 1975Abstract Using a rosetting technique, it was found that the vast majority of basophils circulating in the blood or accumulating in the skin reactions of guinea pigs primed for cutaneous basophil hypersensitivity (CBH) lacked demonstrable specificity for sensitizing antigen, whether sheep erythrocytes, a soluble protein, or tumor cells ...
H F, Dvorak, R B, Colvin, W H, Churchill
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Syk deficiency in nonreleaser basophils☆☆☆★ [PDF]
Background: Peripheral blood basophils from 10% to 20% of donors fail to degranulate in response to cross-linking the high-affinity IgE receptor FceRI. The molecular mechanisms underlying the nonreleaser phenotype have not been established.
Christopher L Kepley +2 more
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Basophil degranulation control
International Journal of Bio-Medical Computing, 1992We first present a global simulation model describing inhibition of human basophil degranulation by means of high dilutions. Then we study an optimal control problem associated to a non-linear compartmental model. This control is associated to an antigen concentration. For solving this control problem we used a dynamic programming method.
B, Hadjaj +2 more
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European Journal of Haematology, 2001
Abstract: Acute basophilic leukemia has recently been included into a revised classification of acute leukemias proposed by the WHO panel. Due to the rarity of the disease, consistent diagnostic criteria are lacking. We report on two cases of acute basophilic leukemia that occurred in our department during the last 10 yr.
A A, Giagounidis +5 more
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Abstract: Acute basophilic leukemia has recently been included into a revised classification of acute leukemias proposed by the WHO panel. Due to the rarity of the disease, consistent diagnostic criteria are lacking. We report on two cases of acute basophilic leukemia that occurred in our department during the last 10 yr.
A A, Giagounidis +5 more
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Journal of Immunological Methods, 1981
A 3-step procedure is described in detail for producing 50% basophils in 50% yield from human blood. Leukocytes from dextran sedimented blood or preferably whole blood are sedimented on Hypaque-Ficoll, then on aqueous Hypaque, followed by adherence and elution from a column of glass beads.
J J, Pruzansky, R, Patterson
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A 3-step procedure is described in detail for producing 50% basophils in 50% yield from human blood. Leukocytes from dextran sedimented blood or preferably whole blood are sedimented on Hypaque-Ficoll, then on aqueous Hypaque, followed by adherence and elution from a column of glass beads.
J J, Pruzansky, R, Patterson
openaire +2 more sources

