Results 91 to 100 of about 298,121 (314)
Терапевтический архив, 2011 Aim. To determine unbalance in the system of programmed cell death in the cells CD34+ of the bone marrow (BM) and peripheral blood (PB) before and after cytostatic impact in acute leukemia (AL). Material and methods.
Elena Evgen'evna Khodunova +11 more
doaj
Бюллетень сибирской медицины, 2005 The study aim: to investigate the dynamics of transcription factor p53, proapoptoic (bax, bcl-XS), antiapoptotic (bcl-2, bcl-XL) effectors, IL-5 expression in peripheral blood eosinophils of patients with severe therapy-resistant bronchial asthma (BA ...
L. Yu. Nikitina +3 more
doaj +1 more source
Effect of EZH2 Inhibition on Colorectal Cancer Cells: an In Vitro Study [PDF]
Journal of Genetic Resources, 2016 Recently, the epigenetic modifications have been recognized as a regulator of gene expression in various cancers. EZH2 gene is one the most important component of the PRC2 complex. Overexpression of EZH2 was identified in multiple cancers that considered
Farnia Ghafouri Sabzevari +3 more
doaj +1 more source
Circulating Cell-Free DNA in Dogs with Mammary Tumors: Short and Long Fragments and Integrity Index [PDF]
, 2017 Circulating cell-free DNA (cfDNA) has been considered an interesting diagnostic/prognostic plasma biomarker in tumor-bearing subjects. In cancer patients, cfDNA can hypothetically derive from tumor necrosis/apoptosis, lysed circulating cells, and some ...
A Asmarinah +79 more
core +5 more sources
Advanced Science, EarlyView.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang +10 more
wiley +1 more source
Heavy Tails Make Happy Buyers [PDF]
arXiv, 2020 In a second-price auction with i.i.d. (independent identically distributed) bidder valuations, adding bidders increases expected buyer surplus if the distribution of valuations has a sufficiently heavy right tail. While this does not imply that a bidder in an auction should prefer for more bidders to join the auction, it does imply that a bidder should
arxiv
The Bax pore in liposomes, Biophysics [PDF]
Cell Death & Differentiation, 2006 The protein BAX of the Bcl-2-family is felt to be one of the two Bcl-2-family proteins that directly participate in the mitochondrial cytochrome c-translocating pore. We have studied the kinetics, stoichiometry and size of the pore formed by BAX in planar lipid bilayers and synthetic liposomes.
Mitsuyoshi Saito, Paul H. Schlesinger
openaire +3 more sources
Advanced Science, EarlyView.Autologous plasma‐derived platelet‐rich fibrin (PRF) is prepared as a protective shield for mesenchymal stem cell spheroids (Sp‐MSCs). PRF forms a fibrin shield to protect Sp‐MSCs from the oxidative stress environment. The nutrients in PRF, particularly the α‐granules, can enhance the repair function of Sp‐MSCs.
Jinglve Zhang +10 more
wiley +1 more source
Low probability Bid-Bax reaction generates heterogeneity in apoptosis resistance of cancer and cancer stem cells [PDF]
arXiv, 2011 Variability in the tumorigenic potential among cancer cells within a tumor population is an unresolved fundamental issue in cancer biology. It is important to know whether cancer cells with higher tumorigenic potential, such as cancer stem cells, are only a small subpopulation.
arxiv
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization
Advanced Science, EarlyView.This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan +12 more
wiley +1 more source