Results 101 to 110 of about 298,121 (314)
Collecting Charges for Ad Impact on User Experience for Different Price Types [PDF]
arXiv, 2019 This note describes how to collect charges for ad impact on user experience. The charge may be per-view, to account for impact on user experience from viewing an ad, or per-click, to account for impact from clicking on the ad. The results for per-click charges also apply to per-conversion charges or per-action charges.
arxiv
Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]
, 2018 Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun +8 more
core +2 more sources
Regulated Targeting of BAX to Mitochondria [PDF]
The Journal of Cell Biology, 1998 The proapoptotic protein BAX contains a single predicted transmembrane domain at its COOH terminus. In unstimulated cells, BAX is located in the cytosol and in peripheral association with intracellular membranes including mitochondria, but inserts into mitochondrial membranes after a death signal.
Atan Gross +7 more
openaire +3 more sources
Advanced Science, EarlyView.The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang +11 more
wiley +1 more source
Application of cryo-electron microscopy for investigation of Bax-induced pores in apoptosis
Nanotechnology Reviews, 2017 Mitochondrial outer membrane permeabilization (MOMP) is a critical step in apoptosis, the molecular mechanisms of which have been a subject of intensive study.
Kuwana Tomomi
doaj +1 more source
The olive biophenols oleuropein and hydroxytyrosol selectively reduce proliferation, influence the cell cycle, and induce apoptosis in pancreatic cancer cells [PDF]
, 2018 Current chemotherapy drugs for pancreatic cancer only offer an increase in survival of up to six months. Additionally, they are highly toxic to normal tissues, drastically affecting the quality of life of patients. Therefore, the search for novel agents,
Bond, Danielle R. +6 more
core +2 more sources
Advanced Science, EarlyView.A theranostic nanoplatform is formulated with NIR‐II emissive lipophilic cyanine dye IRC18 to intercalate into genetically engineered IL12/CSF1R‐macrophage membrane‐liposome hybrid nanovesicles, which assists to achieve blood–brain barrier crossing, glioblastoma targeting, NIR‐II fluorescence imaging, image‐guided membrane‐targeted mild photothermal ...
Pengfei Chen +10 more
wiley +1 more source
Frontiers in Bioscience-LandmarkBackground and Objective: There is a growing need to comprehend the potential outcomes of nanoparticles (NPs) on human well-being, including their potential for detecting and treating leukemia.
Ghada M. Nasr +4 more
doaj +1 more source
Diagnostic Pathology, 2012 Background In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle.
Ozer Hatice +5 more
doaj +1 more source
Speculate-Correct Error Bounds for k-Nearest Neighbor Classifiers [PDF]
arXiv, 2014 We introduce the speculate-correct method to derive error bounds for local classifiers. Using it, we show that k nearest neighbor classifiers, in spite of their famously fractured decision boundaries, have exponential error bounds with O(sqrt((k + ln n) / n)) error bound range for n in-sample examples.
arxiv