Results 61 to 70 of about 317,110 (186)

Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]

, 2020
Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Meng, Xiao-Wen, Peng, Ke, Xia, Fan, Xia, Zheng-Yuan, Zhang, Juan   +8 more
core  

Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. [PDF]

, 2015
BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis
Chen, Yingyu, Deng, Wenbin, Liu, Wenwei, Xiao, Juan   +3 more
core   +2 more sources

Reversal of Hyperglycemia and Suppression of Type 1 Diabetes in the NOD Mouse with Apoptotic DNA Immunotherapy™ (ADi™), ADi-100

Biomedicines, 2020
The antigen-specific apoptotic DNA immunotherapeutic, ADi-100, is designed to suppress type 1 diabetes and consists of two DNA plasmids encoding genetic sequences of the apoptosis-inducing molecule, BAX, and the secreted form of the autoantigen, glutamic
David G. Alleva, Melika Rezaee, Linda Yip, Gang Ren, Jarrett Rosenberg, Waldo Concepcion, Alan Escher, Shahrokh Shabahang, Avnesh S. Thakor   +8 more
doaj   +1 more source

Effect of EZH2 Inhibition on Colorectal Cancer Cells: an In Vitro Study [PDF]

Journal of Genetic Resources, 2016
Recently, the epigenetic modifications have been recognized as a regulator of gene expression in various cancers. EZH2 gene is one the most important component of the PRC2 complex. Overexpression of EZH2 was identified in multiple cancers that considered
Farnia Ghafouri Sabzevari, Madjid Momeni-Moghaddam, Faris Farassati, Abolfazl Rad   +3 more
doaj   +1 more source

Impact of L-carnitine and selenium treatment on testicular apoptosis in rats exposed to 2.45 GHz microwave energy [PDF]

, 2015
Objective: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect.
Comlekci, S., Gumral, N., Karahan, N., Ozguner, M.F., Saygin, M., Çalişkan, Sadettin   +5 more
core   +1 more source

Follow-up study of expression of Bcl-2, Bax, p53 and ACE in CD34+ cells of peripheral blood and bone marrow in acute leukemia patients in the course of induction chemotherapy

Терапевтический архив, 2011
Aim. To determine unbalance in the system of programmed cell death in the cells CD34+ of the bone marrow (BM) and peripheral blood (PB) before and after cytostatic impact in acute leukemia (AL). Material and methods.
Elena Evgen'evna Khodunova, Elena Nikolaevna Parovichnikova, Irina Vladimirovna Gal'tseva, Sergey Mikhaylovich Kulikov, Valentin Grigor'evich Isaev, Valeriy Grigor'evich Savchenko, E E Khodunova, E N Parovichnikova, I V Galtseva, S M Kulikov, V G Isaev, V G Savchenko   +11 more
doaj  

The expression of VDACs and Bcl2 family genes in pituitary adenomas: clinical correlations and postsurgical outcomes

Frontiers in Endocrinology
IntroductionPituitary adenomas (PAs) are benign tumors with high prevalence and, occasionally, aggressive course. The tumorigenesis of these lesions is not completely understood at the molecular level.
AN Facundo, AN Facundo, AN Facundo, M Magalhães, GC Nascimento, GC Nascimento, RS Azulay, RS Azulay, RM Santos, LA Freitas, AGPAC Nascimento, AGPAC Nascimento, VP Rodrigues, VP Rodrigues, WC Santos, WC Santos, AMGS Beckman, JMF Abreu, JMF Abreu, RP Silva, EL Carneiro, CP Oliveira Neto, CP Oliveira Neto, RM Gil da Costa, RM Gil da Costa, RM Gil da Costa, R Corcoy, R Corcoy, E Mato, E Mato, MS Faria, MS Faria, MS Faria   +32 more
doaj   +1 more source

Effects of carfilzomib alone and in combination with cisplatin on the gene expression of Bcl-2 and Bax in ovarian carcinoma cell lines [PDF]

Journal of Preventive and Complementary Medicine
Background: Carfilzomib (CFZ), a proteasome inhibitor, has demonstrated potential in the treatment of ovarian cancer, including variants that are resistant to cisplatin (Cis).Objectives: This study aims to evaluate the effects of CFZ, both as a ...
Alireza Saedi, Javad Zavar Reza, Navid Ghasemzadeh, Moein Moradi, Behnaz Majidi, Amir Hossein Fatehi Marj, Sadegh Zarei   +6 more
doaj   +1 more source

The Induction of Apoptosis by Resveratrol Through Regulatory Effect of miR-21 on the Gene Expression of Bcl2 and Bax in HCT-116 Cells [PDF]

Avicenna Journal of Medical Biochemistry, 2019
Background: Resveratrol (RezV) which is found in several plants including grapes and types of berries has a vital role in inducing apoptosis and suppressing cell proliferation.
Nooshin Shabab, Saeid Afshar, Massoud Saidijam   +2 more
doaj   +1 more source

Cell death and life in cancer: mathematical modeling of cell fate decisions

, 2011
Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells.
Barillot, Emmanuel, Calzone, Laurence, Fourquet, Simon, Tournier, Laurent, Zinovyev, Andrei   +4 more
core   +2 more sources