Results 81 to 90 of about 221,308 (340)
Small Molecule Allosteric Inhibitors of BAX
Nature Chemical Biology, 2018 BAX is a critical effector of the mitochondrial cell death pathway in response to a diverse range of stimuli in physiological and disease contexts. Upon binding by BH3-only proteins, cytosolic BAX undergoes conformational activation and translocation ...
Thomas P. Garner +5 more
semanticscholar +1 more source
The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions
FEBS Open Bio, EarlyView.Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh +2 more
wiley +1 more source
Frontiers in Pharmacology, 2023 Background: Herbs originating from the Aconitum L. (Ranunculaceae), such as Aconitum carmichaelii Debeaux. (Wutou), Aconitum pendulum Busch. (Tiebangchui), and Aconitum kusnezoffii Reichb. (Caowu), etc.
Gelin Xiang +7 more
doaj +1 more source
Journal of the Society for Musicology in Ireland, 2013 Scholars of Arnold Bax have long acknowledged the influence of the Irish Literary Revival on the composer’s compositional output up to about 1920, of Sibelius from the late 1920s onwards, and of the continuity of styles between these two periods. In this article I argue that this continuity relies on what Bax draws from early Yeats, which is less ...
openaire +2 more sources
Bax mitochondrial residency is more critical than Bax oligomerization for apoptosis [PDF]
, 2019 AbstractThe Bax protein plays an important effector role in apoptosis by forming pores in the mitochondrial outer membrane. While doing so, Bax forms higher-order oligomers in the membrane, but it remains unclear whether this oligomer formation is essential for pore formation. Using cell-free and cellular experimental systems, we investigated two Bax C-
Kuwana, Tomomi +6 more
openaire +2 more sources
Advanced Functional Materials, EarlyView.The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen +13 more
wiley +1 more source
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.BX‐001N, a polyethylene glycol‐conjugated bilirubin 3α nanoparticle, is the first GMP‐grade, synthetic bilirubin‐based nanomedicine. It effectively attenuates acute renal injury, facilitates subacute renal recovery, and suppresses chronic fibrosis after renal ischemia/reperfusion injury via anti‐oxidant and immune‐modulating activity.
Ji‐Jing Yan +13 more
wiley +1 more source
Терапевтический архив, 2011 Aim. To determine unbalance in the system of programmed cell death in the cells CD34+ of the bone marrow (BM) and peripheral blood (PB) before and after cytostatic impact in acute leukemia (AL). Material and methods.
Elena Evgen'evna Khodunova +11 more
doaj
bioRxiv, 2018 During apoptosis, Bcl-2 proteins such as Bax and Bak mediate the release of pro-apoptotic proteins from the mitochondria by clustering on the outer mitochondrial membrane and thereby permeabilizing it.
Nicholas R. Ader +6 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.An RBC membrane camouflaged, cell‐penetrating peptides R8‐based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), inducing tumor cell apoptosis, reducing tumor metastasis invasion and triggering autophagy disorder in breast cancer and liver cancer.
Qian Cheng +6 more
wiley +1 more source