Results 21 to 30 of about 141,528 (311)

Spectrum of twisted Dirac operators on the complex projective space $\Bbb P^{2q+1}(\Bbb C)$

, 1989
summary:In this paper, we explicitly determine the spectrum of Dirac operators acting on smooth sections of twisted spinor bundles over the complex projective space $\Bbb P^{2q+1}(\Bbb C)$ for $q\geq 1$
Cahen, Michel, Halima, Majdi Ben, Franc, Annick, Gutt, Simone   +3 more
core   +1 more source

BBB leakage assessment.

, 2021
In order to confirm that blood-brain barrier leakage was not a confound in our experiment, we later assessed available APOE4 rats (n = 5) that were slightly older (16 months) and on a high fat diet- both of which would exacerbate BBB leakage if present. (
Marc D. Normandin (1583074), Dharshan Chandramohan (11348926), Ju Qiao (6004292), Anne L. van de Ven (11348929), Liam Timms (11348932), Craig F. Ferris (7123448), Georges El Fakhri (520533), Codi Gharagouzloo (11348935), Jorge Sepulcre (81907), Praveen Kulkarni (433608), Chao Ma (207385), Joshua Leaston (11348923)   +11 more
core   +1 more source

Bioengineered microfluidic blood-brain barrier models in oncology research

Translational Oncology, 2021
Metastasis is the major reason for most brain tumors with up to a 50% chance of occurrence in patients with other types of malignancies. Brain metastasis occurs if cancer cells succeed to cross the ‘blood-brain barrier’ (BBB).
Robin Augustine, Ahmad H. Aqel, Sumama Nuthana Kalva, K.S. Joshy, Ajisha Nayeem, Anwarul Hasan   +5 more
doaj   +1 more source

Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood − brain barrier function

Fluids and Barriers of the CNS, 2023
Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into the central nervous system (CNS) play a crucial role in the initiation of demyelination and neurodegeneration in multiple sclerosis (MS).
Baharak Hosseinkhani, Gayel Duran, Cindy Hoeks, Doryssa Hermans, Melissa Schepers, Paulien Baeten, Joren Poelmans, Britt Coenen, Kübra Bekar, Isabel Pintelon, Jean-Pierre Timmermans, Tim Vanmierlo, Luc Michiels, Niels Hellings, Bieke Broux   +14 more
doaj   +1 more source

review on the role of nanoparticles for targeted brain drug delivery

EXCLI Journal : Experimental and Clinical Sciences
Unfortunately, nowadays, brain disorders, which include both neurological and mental disorders, are the main cause of years spent living with a disability worldwide. There are serious diseases with a high prevalence and a high mortality rate.
Payam Nawzad Mohammed, Narmin Hamaamin Hussen, Aso Hameed Hasan, Hozan Jaza Hama Salh, Joazaizulfazli Jamalis, Sumeer Ahmed, Ajmal R. Bhat, Mohammad Amjad Kamal   +7 more
doaj   +1 more source

Revisiting strategies to target ABC transporter-mediated drug resistance in CNS cancer

Cancer Biology & Medicine
A significant number of anticancer drugs fail to treat primary and metastatic brain tumors primarily because of the complex blood-brain barrier (BBB) and overexpression of ATP-binding cassette (ABC) transporters, which decrease drug penetration into the ...
Haneen Amawi, Alaa M. Hammad, F. Scott Hall, Noor Hussein, Aseel O. Rataan, Abeer Mrayyan, Taqwa Al-kofahi, Ali Hmedat, Charles R. Ashby, Amit K. Tiwari   +9 more
doaj   +1 more source

Ensemble Predictions for TDC BBB-Martins Leaderboard

, 2023
Ensemble predictions for a drugs ability to penetrate the blood brain barrier using Therapeutic Data Commons BBB-Martins dataset. Includes .tsv files with the actual and predicted classifications of BBB permeability for each drug in the TDC test set ...
Rick Fontenot (14855842)
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dynamic Interleukin-1 Receptor Type 1 Signaling Mediates Microglia-Vasculature Interactions Following Repeated Systemic LPS

Journal of Inflammation Research, 2022
Daniel P Nemeth,1– 3 Xiaoyu Liu,3 Daniel B McKim,4 Damon J DiSabato,2,5 Braedan Oliver,2 Anu Herd,3 Asish Katta,1 Christina E Negray,1,2 James Floyd,3 Samantha McGovern,3 Paige S Pruden,2 Feiyang Zhutang,2 Maria Smirnova,3 Jonathan P Godbout,2,5 John ...
Nemeth DP, Liu X, McKim DB, DiSabato DJ, Oliver B, Herd A, Katta A, Negray CE, Floyd J, McGovern S, Pruden PS, Zhutang F, Smirnova M, Godbout JP, Sheridan JF, Quan N   +15 more
doaj  

Treatment with penicillin G and hydrocortisone reduces ALS-associated symptoms: a case series of three patients [version 1; referees: 2 approved]

F1000Research, 2017
Three male Caucasian patients with ALS were admitted to the hospital due to progressive dysphagia and dysarthria. During two 21-day courses of penicillin G and hydrocortisone, these patients’ dysphagia and dysarthria resolved.
Bert Tuk, Harmen Jousma, Pieter J. Gaillard   +2 more
doaj   +1 more source