Results 81 to 90 of about 117,524 (267)

Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells

mSphere, 2017
Bacterial meningitis is a serious infection of the central nervous system (CNS) that occurs after bacteria interact with and penetrate the blood-brain barrier (BBB). The BBB is comprised of highly specialized brain microvascular endothelial cells (BMECs)
Brandon J. Kim, Olivia B. Bee, Maura A. McDonagh, Matthew J. Stebbins, Sean P. Palecek, Kelly S. Doran, Eric V. Shusta   +6 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Blood-Nanoparticle Interactions Create a Brain Delivery Superhighway for Doxorubicin

International Journal of Nanomedicine
Zhuoxuan Li,1 Tatyana Kovshova,2 Julia Malinovskaya,2 Julian Knoll,1 Saeed Shanehsazzadeh,1 Nadezhda Osipova,2 Anastasia Chernysheva,3 Pavel Melnikov,2 Svetlana Gelperina,2 Matthias G Wacker1 1National University of Singapore, Department of Pharmacy and ...
Li Z, Kovshova T, Malinovskaya J, Knoll J, Shanehsazzadeh S, Osipova N, Chernysheva A, Melnikov P, Gelperina S, Wacker MG   +9 more
doaj  

BBB-conquering antibodies [PDF]

Science-Business eXchange, 2014
Roche has developed an improved transferrin receptor–targeting strategy that dramatically increases delivery of biologics to the brain. The team showed proof of concept in mice and now needs to adapt the system for primate brains.
openaire   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

The number of subgroups of the group $\Bbb{Z}_m\times \Bbb{Z}_n \times \Bbb{Z}_r \times \Bbb{Z}_s$

, 2016
13 pages ...
openaire   +2 more sources

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Minimal surfaces in ${\Bbb M}\sp 2\times\Bbb R$

Illinois Journal of Mathematics, 2002
We study the geometry and topology of properly embedded minimal surfaces in $M\times\mathbb{R}$, where $M$ is a Riemannian surface. When $M$ is a round sphere, we give examples of all genus and we prove such minimal surfaces have exactly two ends or equal $M\times\{t\}$, for some real $t$.
openaire   +2 more sources

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Microstructural and phase evolution of BaTiO3–BaO–B2O3–Bi2O3 glass composites during pressureless and spark plasma sintering

Materials & Design
BaTiO3–BaO–B2O3–Bi2O3 (BBB) glass composites were investigated to clarify how BBB content and sintering route control low-temperature densification, pore evolution, glass-derived phase redistribution, and crystalline phase development.
Alfian Noviyanto, Faried Latief, Bagas Haqi Arrosyid, Hiroyo Segawa, Toshiyuki Nishimura, Naoki Ohashi   +5 more
doaj   +1 more source