Results 231 to 240 of about 153,854 (301)

Beyond the Board: Does CEO‐CFO Tenure Staggering Curb ESG Greenwashing?

Business Strategy and the Environment, EarlyView.
ABSTRACT Greenwashing threatens the credibility of corporate environmental strategies and ESG disclosure by creating a disconnect between symbolic claims and substantive action. Existing research mainly focuses on external pressures and formal governance mechanisms, with limited attention to the relational structure of the top management team ...
Zhe Sun, Jingyi Wang, Dimitrios Asteriou, Liang Zhao, Juanxi Wang   +4 more
wiley   +1 more source

Hypothetical applications of MR-guided focused ultrasound in central nervous system tuberculosis: blood-brain barrier disruption, granulomatous lesion modulation, targeted drug delivery, and immune microenvironment reprogramming. [PDF]

Ann Med Surg (Lond)
Beniwal SS, Mwaanga C, Jassim M, Rawat A, Dahiya P, Ribeiro da Costa REA, Pandey A, Ali ASM, Moncada J, Mateen SSA, Mishra A.   +10 more
europepmc   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

The Impact of Overtraining on Anxiety-Like Behavior and Tight Junction Proteins of the Blood-Brain Barrier in Mice. [PDF]

Brain Behav
Hwang E, Shin M, Park T, Kim JJ, Yi D, Park J, Moon HY.   +6 more
europepmc   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

The C5a-C5aR1 axis facilitates blood-brain barrier disruption induced by EV-A71 infection through neutrophil activation. [PDF]

PLoS Pathog
Zhu P, Zeng X, Yuan X, Li Z, Ji W, Li D, Sun T, Yang H, Chen S, Long J, Wang F, Zhang Y, Shen A, Zhang W, Jin Y, Duan G.   +15 more
europepmc   +1 more source

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, EarlyView.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source

Exosomes in brain diseases: Mechanisms, advances, and perspectives. [PDF]

Bioact Mater
Cheng Q, Zhu Y, Lv S, Chen R, Liu P, Ji X.   +5 more
europepmc   +1 more source